Last reviewed · How we verify
UFT, Calcium Folinate, PSK
UFT is a prodrug that is converted into 5-fluorouracil, a thymidylate synthase inhibitor.
UFT is a prodrug that is converted into 5-fluorouracil, a thymidylate synthase inhibitor. Used for Colorectal cancer, Gastric cancer.
At a glance
| Generic name | UFT, Calcium Folinate, PSK |
|---|---|
| Sponsor | Iwate Medical University |
| Drug class | Antineoplastic |
| Target | Thymidylate synthase |
| Modality | Small molecule |
| Therapeutic area | Oncology |
| Phase | Phase 3 |
Mechanism of action
Calcium folinate is used to counteract the toxic effects of 5-fluorouracil on the bone marrow. PSK is a polysaccharide-Krestin, a biological response modifier that enhances the immune system's ability to fight cancer.
Approved indications
- Colorectal cancer
- Gastric cancer
Common side effects
- Diarrhea
- Leukopenia
- Nausea
- Vomiting
- Stomatitis
Key clinical trials
- A Phase III Trial Comparing UFT+PSK to UFT+LV in Stage IIB, III Colorectal Cancer (PHASE3)
- Uracil and Tegafur/Leucovorin (UFT/LV) Versus UFT/LV+ Polysaccharide-K (PSK) for Stage IIIa/IIIb Colorectal Cancer (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |