{"id":"uft-calcium-folinate-psk","safety":{"commonSideEffects":[{"rate":"30-50%","effect":"Diarrhea"},{"rate":"20-40%","effect":"Leukopenia"},{"rate":"20-40%","effect":"Nausea"},{"rate":"10-30%","effect":"Vomiting"},{"rate":"10-30%","effect":"Stomatitis"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Calcium folinate is used to counteract the toxic effects of 5-fluorouracil on the bone marrow. PSK is a polysaccharide-Krestin, a biological response modifier that enhances the immune system's ability to fight cancer.","oneSentence":"UFT is a prodrug that is converted into 5-fluorouracil, a thymidylate synthase inhibitor.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:52:09.028Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Colorectal cancer"},{"name":"Gastric cancer"}]},"trialDetails":[{"nctId":"NCT00385970","phase":"PHASE3","title":"A Phase III Trial Comparing UFT+PSK to UFT+LV in Stage IIB, III Colorectal Cancer","status":"UNKNOWN","sponsor":"Multicenter Clinical Study Group of Osaka, Colorectal Cancer Treatment Group","startDate":"2006-03","conditions":"Colorectal Cancer","enrollment":380},{"nctId":"NCT00497107","phase":"PHASE3","title":"Uracil and Tegafur/Leucovorin (UFT/LV) Versus UFT/LV+ Polysaccharide-K (PSK) for Stage IIIa/IIIb Colorectal Cancer","status":"UNKNOWN","sponsor":"Iwate Medical University","startDate":"2007-07","conditions":"Colorectal Cancer","enrollment":300}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":10,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"UFT, Calcium Folinate, PSK","genericName":"UFT, Calcium Folinate, PSK","companyName":"Iwate Medical University","companyId":"iwate-medical-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"UFT (Tegafur-uracil) is a small molecule used in combination with other treatments for colorectal cancer. Calcium folinate is a small molecule with an unknown mechanism, often used in combination with UFT for this condition.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}