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Tham (trometamol)
Tham (generic name: trometamol) is a trometamol drug developed by Pfizer. It is currently FDA-approved (first approved 1965) for Allergic conjunctivitis, Post-Op Ocular Inflammation, Post-Op Photophobia.
Tham, also known as tromethamine or THAM, is a small molecule used in medical research and has been studied in various clinical trials for conditions such as polytrauma, post-operative anterior chamber inflammation, and retinopathy of prematurity. It has been used in combination with ketorolac tromethamine 0.45% in some trials, and has been used as a component of buffer solutions in biochemistry and molecular biology.
At a glance
| Generic name | trometamol |
|---|---|
| Sponsor | Pfizer |
| Drug class | trometamol |
| Therapeutic area | Ophthalmology |
| Phase | FDA-approved |
| First approval | 1965 |
Approved indications
- Allergic conjunctivitis
- Post-Op Ocular Inflammation
- Post-Op Photophobia
- Postoperative Ocular Pain
Common side effects
- Respiratory depression
- Hepatocellular necrosis
- Venous thrombosis or phlebitis
- Hypervolemia
- Local tissue damage and subsequent sloughing
- Chemical phlebitis
- Venospasm
- Infection at the site of injection
- Febrile response
Key clinical trials
- A Study of LBP-EC01 in the Treatment of Acute Uncomplicated UTI Caused by Drug Resistant E. Coli (ELIMINATE Trial) (PHASE2)
- The Efficiency of Periarticular Multimodal Drug Injection in Pain Management Following Primary Unilateral TKA (NA)
- Nonopioid Analgesia After Anterior Cruciate Ligament Reconstruction (PHASE2,PHASE3)
- Ear Pressure Points Plus Pain Meds for Faster Kidney Stone Pain Relief (NA)
- Low-Dose Short-Term Ketorolac to Reduce Chronic Opioid Use in Orthopaedic Polytrauma Patients (PHASE4)
- NSAID Injection Versus Corticosteroid Injection for Basilar Thumb Arthritis (PHASE3)
- A Study of Tris-Hydroxymethyl Aminomethane (THAM) Versus Sodium Bicarbonate in Cardiac Surgical Patients (PHASE4)
- Ketorolac Intravenous Regional Analgesia in Lower Limb Surgeries (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| FDA label | Mechanism, indications, dosing, boxed warnings, drug interactions |
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Tham CI brief — competitive landscape report
- Tham updates RSS · CI watch RSS
- Pfizer portfolio CI
Frequently asked questions about Tham
What is Tham?
What is Tham used for?
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What is the generic name of Tham?
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When was Tham approved?
What development phase is Tham in?
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Related
- Drug class: All trometamol drugs
- Manufacturer: Pfizer — full pipeline
- Therapeutic area: All drugs in Ophthalmology
- Indication: Drugs for Allergic conjunctivitis
- Indication: Drugs for Post-Op Ocular Inflammation
- Indication: Drugs for Post-Op Photophobia
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing