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NCT07424625
THAM VErsus Sodium BiCarbOnate In CaRdiac SuRgical PatiEnts, A PragmatiC, Comparative-effectiveness Prospective Trial
Phase 4 trial testing Sodium bicarbonate in Metabolic Acidosis in 250 participants. Not yet recruiting.
1 February 2027
Quick facts
| Lead sponsor | Mayo Clinic |
|---|---|
| Phase | Phase 4 |
| Status | Not yet recruiting |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 250 |
| Start date | 1 May 2026 |
| Primary completion | 1 February 2027 |
| Estimated completion | 1 August 2027 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Sodium bicarbonate (Sodium Bicarbonate) — full drug profile →
- Tris-hydroxymethyl Aminomethane — full drug profile →
Conditions studied
- Metabolic Acidosis — all drugs for Metabolic Acidosis →
Sponsor
Mayo Clinic
Who can join
21 and older, any sex, with Metabolic Acidosis. Patients with the condition only — healthy volunteers not accepted.
What's being measured
Primary outcomes are the specific endpoints the trial is designed to prove or disprove.
-
Change in pH following buffer administration
Time frame: Baseline, 2 hours
pH will be measured via arterial blood gas test
Sponsor's own description
The purpose of this research is to determine if two commonly used medications to treat metabolic acidosis in the setting of cardiac surgery, sodium bicarbonate and THAM, are equivalent.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07424625
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Sodium bicarbonate
Trials testing the same drug.
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- NCT06622525 — Use of Sodium Bicarbonate as Prophylaxis for Kidney Damage in Patients With Heatstroke · NA · recruiting
- NCT06047366 — Combination of Buffered Anesthetic to Treat Mandibular Molars · Phase 4 · terminated
- NCT04984226 — Sodium Bicarbonate and Mitochondrial Energetics in Persons With CKD · Phase 2 · recruiting
- NCT05564130 — Bicarbonate for In-Hospital Cardiac Arrest · Phase 4 · active not recruiting
Other recruiting trials for Metabolic Acidosis
Currently open trials in the same condition.
- NCT06366230 — Adding Urea to the Final Dialysis Fluid · Phase 1, PHASE2 · recruiting
- NCT06881641 — A Study on Bedside Formate Assay as a Diagnostic Tool in Methanol Poisoning · recruiting
- NCT06545565 — Prevention of Metabolic Acidosis in Preterm Neonates by Replacing Sodium Chloride With Sodium Acetate in Parenteral Nutr · Phase 3 · recruiting
- NCT06932042 — PLADO for Conservative Management of CKD · NA · recruiting
- NCT04984226 — Sodium Bicarbonate and Mitochondrial Energetics in Persons With CKD · Phase 2 · recruiting
Other Mayo Clinic trials
Trials by the same sponsor.
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- NCT07086183 — Perioperative Risk in Patients on Chronic Aspirin Undergoing Craniotomy · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07424625 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Mayo Clinic
- Last refreshed: 22 April 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07424625.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing