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Triamcinolone Acetonide/5-fluorouracil mixture
Triamcinolone Acetonide is a corticosteroid that reduces inflammation, while 5-fluorouracil is an antimetabolite that interferes with DNA synthesis, making cancer cells more susceptible to death.
Triamcinolone Acetonide is a corticosteroid that reduces inflammation, while 5-fluorouracil is an antimetabolite that interferes with DNA synthesis, making cancer cells more susceptible to death. Used for Actinic keratosis, Seborrheic keratosis.
At a glance
| Generic name | Triamcinolone Acetonide/5-fluorouracil mixture |
|---|---|
| Sponsor | University of Washington |
| Drug class | Corticosteroid/antimetabolite |
| Modality | Small molecule |
| Therapeutic area | Oncology |
| Phase | Phase 3 |
Mechanism of action
Triamcinolone Acetonide works by inhibiting the production of inflammatory mediators, which reduces swelling and pain. 5-fluorouracil, on the other hand, is a thymidylate synthase inhibitor that disrupts DNA synthesis, leading to cell death in rapidly dividing cancer cells.
Approved indications
- Actinic keratosis
- Seborrheic keratosis
Common side effects
- Skin irritation
- Pruritus
- Erythema
Key clinical trials
- A Randomized, Double-blinded, Self-controlled Clinical Study of Intralesional Injection of 5-fluorouracil Plus Triamcinolone for the Treatment of Refractory Nodular Prurigo (PHASE3)
- Intralesional Triamcinolone Acetonide and Its Combination With 5-fluorouracil in Keloids and Hypertrophic Scars (NA)
- Local 5-Fluorouracil Injection for the Treatment of Chalazia: A Prospective, Comparative Study (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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