{"id":"triamcinolone-acetonide-5-fluorouracil-mixture","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Skin irritation"},{"rate":"5-10%","effect":"Pruritus"},{"rate":"5-10%","effect":"Erythema"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Triamcinolone Acetonide works by inhibiting the production of inflammatory mediators, which reduces swelling and pain. 5-fluorouracil, on the other hand, is a thymidylate synthase inhibitor that disrupts DNA synthesis, leading to cell death in rapidly dividing cancer cells.","oneSentence":"Triamcinolone Acetonide is a corticosteroid that reduces inflammation, while 5-fluorouracil is an antimetabolite that interferes with DNA synthesis, making cancer cells more susceptible to death.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:40:05.244Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Actinic keratosis"},{"name":"Seborrheic keratosis"}]},"trialDetails":[{"nctId":"NCT06524323","phase":"PHASE3","title":"A Randomized, Double-blinded, Self-controlled Clinical Study of Intralesional Injection of 5-fluorouracil Plus Triamcinolone for the Treatment of Refractory Nodular Prurigo","status":"NOT_YET_RECRUITING","sponsor":"Second Affiliated Hospital, School of Medicine, Zhejiang University","startDate":"2024-09-01","conditions":"Nodular Prurigo","enrollment":60},{"nctId":"NCT04812626","phase":"NA","title":"Intralesional Triamcinolone Acetonide and Its Combination With 5-fluorouracil in Keloids and Hypertrophic Scars","status":"COMPLETED","sponsor":"B.P. Koirala Institute of Health Sciences","startDate":"2021-01-28","conditions":"Scar Keloid","enrollment":66},{"nctId":"NCT02025023","phase":"PHASE3","title":"Local 5-Fluorouracil Injection for the Treatment of Chalazia: A Prospective, Comparative Study","status":"RECRUITING","sponsor":"University of Washington","startDate":"2013-12","conditions":"Chalazion","enrollment":120}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":7,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Triamcinolone Acetonide/5-fluorouracil mixture","genericName":"Triamcinolone Acetonide/5-fluorouracil mixture","companyName":"University of Washington","companyId":"university-of-washington","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Triamcinolone Acetonide is a corticosteroid that reduces inflammation, while 5-fluorouracil is an antimetabolite that interferes with DNA synthesis, making cancer cells more susceptible to death. Used for Actinic keratosis, Seborrheic keratosis.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}