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Tranilast, and Tissucol
Tranilast, and Tissucol is a Anti-fibrotic agent (Tranilast); Fibrin sealant (Tissucol) Small molecule drug developed by Gildasio Castello de Almeida Junior. It is currently in Phase 3 development for Hypertrophic scars and keloid prevention/treatment, Post-surgical wound healing and hemostasis. Also known as: Rizaben, Tissucol.
Tranilast inhibits fibroblast proliferation and collagen synthesis, while Tissucol is a fibrin sealant that promotes tissue adhesion and hemostasis.
Tranilast inhibits fibroblast proliferation and collagen synthesis, while Tissucol is a fibrin sealant that promotes tissue adhesion and hemostasis. Used for Hypertrophic scars and keloid prevention/treatment, Post-surgical wound healing and hemostasis.
At a glance
| Generic name | Tranilast, and Tissucol |
|---|---|
| Also known as | Rizaben, Tissucol |
| Sponsor | Gildasio Castello de Almeida Junior |
| Drug class | Anti-fibrotic agent (Tranilast); Fibrin sealant (Tissucol) |
| Target | TGF-β pathway (Tranilast); Fibrin polymerization (Tissucol) |
| Modality | Small molecule |
| Therapeutic area | Dermatology, Wound Healing, Surgery |
| Phase | Phase 3 |
Mechanism of action
Tranilast is an anti-allergic and anti-fibrotic agent that suppresses transforming growth factor-beta (TGF-β) signaling and reduces fibroblast activity, thereby limiting excessive collagen deposition and scar formation. Tissucol is a two-component fibrin glue composed of fibrinogen and thrombin that creates a physiologic clot to seal tissues and promote wound healing. The combination may leverage Tranilast's anti-fibrotic properties alongside Tissucol's hemostatic and adhesive functions.
Approved indications
- Hypertrophic scars and keloid prevention/treatment
- Post-surgical wound healing and hemostasis
Common side effects
- Local irritation or inflammation at application site
- Allergic reaction to fibrin components
- Infection at wound site
Key clinical trials
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Tranilast, and Tissucol CI brief — competitive landscape report
- Tranilast, and Tissucol updates RSS · CI watch RSS
- Gildasio Castello de Almeida Junior portfolio CI
Frequently asked questions about Tranilast, and Tissucol
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Related
- Drug class: All Anti-fibrotic agent (Tranilast); Fibrin sealant (Tissucol) drugs
- Target: All drugs targeting TGF-β pathway (Tranilast); Fibrin polymerization (Tissucol)
- Manufacturer: Gildasio Castello de Almeida Junior — full pipeline
- Therapeutic area: All drugs in Dermatology, Wound Healing, Surgery
- Indication: Drugs for Hypertrophic scars and keloid prevention/treatment
- Indication: Drugs for Post-surgical wound healing and hemostasis
- Also known as: Rizaben, Tissucol
- Compare: Tranilast, and Tissucol vs similar drugs
- Pricing: Tranilast, and Tissucol cost, discount & access