{"id":"tranilast-and-tissucol","safety":{"commonSideEffects":[{"rate":null,"effect":"Local irritation or inflammation at application site"},{"rate":null,"effect":"Allergic reaction to fibrin components"},{"rate":null,"effect":"Infection at wound site"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"anthropic-haiku","explanation":"Tranilast is an anti-allergic and anti-fibrotic agent that suppresses transforming growth factor-beta (TGF-β) signaling and reduces fibroblast activity, thereby limiting excessive collagen deposition and scar formation. Tissucol is a two-component fibrin glue composed of fibrinogen and thrombin that creates a physiologic clot to seal tissues and promote wound healing. The combination may leverage Tranilast's anti-fibrotic properties alongside Tissucol's hemostatic and adhesive functions.","oneSentence":"Tranilast inhibits fibroblast proliferation and collagen synthesis, while Tissucol is a fibrin sealant that promotes tissue adhesion and hemostasis.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T01:39:47.226Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hypertrophic scars and keloid prevention/treatment"},{"name":"Post-surgical wound healing and hemostasis"}]},"trialDetails":[{"nctId":"NCT01003613","phase":"PHASE3","title":"Evaluation of Tranilast to Treat Pterygium Before Excision","status":"COMPLETED","sponsor":"Gildasio Castello de Almeida Junior","startDate":"2009-02","conditions":"Pterygium","enrollment":32}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Rizaben, Tissucol"],"phase":"phase_3","status":"active","brandName":"Tranilast, and Tissucol","genericName":"Tranilast, and Tissucol","companyName":"Gildasio Castello de Almeida Junior","companyId":"gildasio-castello-de-almeida-junior","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Tranilast inhibits fibroblast proliferation and collagen synthesis, while Tissucol is a fibrin sealant that promotes tissue adhesion and hemostasis. Used for Hypertrophic scars and keloid prevention/treatment, Post-surgical wound healing and hemostasis.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}