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Total Glucosides Paeony Capsules
Total Glucosides of Paeony (TGP) modulates immune function and reduces inflammatory responses through multiple pathways including T cell regulation and cytokine suppression.
Total Glucosides of Paeony (TGP) modulates immune function and reduces inflammatory responses through multiple pathways including T cell regulation and cytokine suppression. Used for Rheumatoid arthritis, Systemic lupus erythematosus, Other autoimmune and inflammatory disorders.
At a glance
| Generic name | Total Glucosides Paeony Capsules |
|---|---|
| Sponsor | Sun Yat-sen University |
| Drug class | Herbal extract immunomodulator |
| Modality | Small molecule |
| Therapeutic area | Immunology / Rheumatology |
| Phase | FDA-approved |
Mechanism of action
TGP is a standardized extract from Paeonia lactiflora that acts as an immunomodulator, primarily by promoting regulatory T cell differentiation and suppressing pro-inflammatory cytokine production. It has been shown to inhibit Th1/Th17 cell differentiation while enhancing Treg cell development, making it useful in autoimmune and inflammatory conditions. The mechanism involves modulation of NF-κB signaling and other intracellular pathways involved in immune activation.
Approved indications
- Rheumatoid arthritis
- Systemic lupus erythematosus
- Other autoimmune and inflammatory disorders
Common side effects
- Gastrointestinal disturbance
- Mild allergic reactions
- Headache
Key clinical trials
- Treatment of Oral Lichen Planus With Paeoniflorin and Photodynamic Therapy (NA)
- Efficacy and Safety Study of Total Glucosides of Paeony Combined With Acitretin to Treat Psoriasis (NA)
- Total Glucosides Paeony Capsules in Maintaining Clinical Remission in Patients With Ankylosing Spondylitis Which Achieve Clinical Remission After Anti-TNF Therapy (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Total Glucosides Paeony Capsules CI brief — competitive landscape report
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