{"id":"total-glucosides-paeony-capsules","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal disturbance"},{"rate":null,"effect":"Mild allergic reactions"},{"rate":null,"effect":"Headache"}]},"_chembl":{"chemblId":"CHEMBL2108906","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"TGP is a standardized extract from Paeonia lactiflora that acts as an immunomodulator, primarily by promoting regulatory T cell differentiation and suppressing pro-inflammatory cytokine production. It has been shown to inhibit Th1/Th17 cell differentiation while enhancing Treg cell development, making it useful in autoimmune and inflammatory conditions. The mechanism involves modulation of NF-κB signaling and other intracellular pathways involved in immune activation.","oneSentence":"Total Glucosides of Paeony (TGP) modulates immune function and reduces inflammatory responses through multiple pathways including T cell regulation and cytokine suppression.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:13:25.195Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Rheumatoid arthritis"},{"name":"Systemic lupus erythematosus"},{"name":"Other autoimmune and inflammatory disorders"}]},"trialDetails":[{"nctId":"NCT05973097","phase":"NA","title":"Treatment of Oral Lichen Planus With Paeoniflorin and Photodynamic Therapy","status":"RECRUITING","sponsor":"Peking University Third Hospital","startDate":"2023-07-30","conditions":"Oral Lichen Planus","enrollment":156},{"nctId":"NCT02191020","phase":"NA","title":"Efficacy and Safety Study of Total Glucosides of Paeony Combined With Acitretin to Treat Psoriasis","status":"COMPLETED","sponsor":"Xijing Hospital","startDate":"2013-02","conditions":"Psoriasis","enrollment":108},{"nctId":"NCT01517620","phase":"PHASE4","title":"Total Glucosides Paeony Capsules in Maintaining Clinical Remission in Patients With Ankylosing Spondylitis Which Achieve Clinical Remission After Anti-TNF Therapy","status":"COMPLETED","sponsor":"Sun Yat-sen University","startDate":"2011-11","conditions":"Ankylosing Spondylitis","enrollment":38}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":11,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Total Glucosides Paeony Capsules","genericName":"Total Glucosides Paeony Capsules","companyName":"Sun Yat-sen University","companyId":"sun-yat-sen-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Total Glucosides of Paeony (TGP) modulates immune function and reduces inflammatory responses through multiple pathways including T cell regulation and cytokine suppression. Used for Rheumatoid arthritis, Systemic lupus erythematosus, Other autoimmune and inflammatory disorders.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}