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Topical Ketoprofen 10% Cream
Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis, thereby decreasing inflammation and pain at the site of topical application.
Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis, thereby decreasing inflammation and pain at the site of topical application. Used for Topical treatment of musculoskeletal pain and inflammation, Localized joint and soft tissue pain.
At a glance
| Generic name | Topical Ketoprofen 10% Cream |
|---|---|
| Also known as | Ketotransdel (TDLP-110) |
| Sponsor | Imprimis Pharmaceuticals, Inc. |
| Drug class | NSAID (nonsteroidal anti-inflammatory drug) |
| Target | COX-1, COX-2 |
| Modality | Small molecule |
| Therapeutic area | Pain Management / Rheumatology |
| Phase | Phase 3 |
Mechanism of action
Ketoprofen blocks COX-1 and COX-2 enzymes, which are responsible for producing prostaglandins that mediate inflammation, pain, and fever. When applied topically as a 10% cream, it delivers the drug directly to affected tissues, reducing systemic exposure compared to oral formulations. This localized anti-inflammatory and analgesic effect is used to treat musculoskeletal pain and inflammation.
Approved indications
- Topical treatment of musculoskeletal pain and inflammation
- Localized joint and soft tissue pain
Common side effects
- Local skin irritation or erythema
- Contact dermatitis
- Pruritus at application site
Key clinical trials
- Multiprofen-CC to Reduce Pain in Hand Arthritis (PHASE3)
- Multiprofen-CC™ to Reduce Pain After Total Knee Arthroplasty (PHASE3)
- Efficacy Study Comparing Compounded Topical Pain Creams vs. Placebo for Treating Pain Symptoms (PHASE3)
- Efficacy and Safety of Impracor (Ketoprofen 10% Cream) Compared With Placebo in the Treatment of Acute Pain (Flare) Associated With Osteoarthritis of the Knee (PHASE3)
- Ketoprofen 10% Cream for Treatment of Pain Associated With Mild to Moderate Acute Soft Tissue Injury (PHASE3)
- Ketoprofen 10% Cream for Treatment of Pain Associated With Mild to Moderate Acute Soft Tissue Injury (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Topical Ketoprofen 10% Cream CI brief — competitive landscape report
- Topical Ketoprofen 10% Cream updates RSS · CI watch RSS
- Imprimis Pharmaceuticals, Inc. portfolio CI