{"id":"topical-ketoprofen-10-cream","safety":{"commonSideEffects":[{"rate":null,"effect":"Local skin irritation or erythema"},{"rate":null,"effect":"Contact dermatitis"},{"rate":null,"effect":"Pruritus at application site"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"anthropic-haiku","explanation":"Ketoprofen blocks COX-1 and COX-2 enzymes, which are responsible for producing prostaglandins that mediate inflammation, pain, and fever. When applied topically as a 10% cream, it delivers the drug directly to affected tissues, reducing systemic exposure compared to oral formulations. This localized anti-inflammatory and analgesic effect is used to treat musculoskeletal pain and inflammation.","oneSentence":"Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis, thereby decreasing inflammation and pain at the site of topical application.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:54:21.048Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Topical treatment of musculoskeletal pain and inflammation"},{"name":"Localized joint and soft tissue pain"}]},"trialDetails":[{"nctId":"NCT06966206","phase":"PHASE3","title":"Multiprofen-CC to Reduce Pain in Hand Arthritis","status":"NOT_YET_RECRUITING","sponsor":"McMaster University","startDate":"2026-01-01","conditions":"Hand Osteoarthritis","enrollment":42},{"nctId":"NCT06202989","phase":"PHASE3","title":"Multiprofen-CC™ to Reduce Pain After Total Knee Arthroplasty","status":"RECRUITING","sponsor":"KAZM Pharmaceuticals Inc.","startDate":"2024-09-09","conditions":"Postsurgical Pain","enrollment":288},{"nctId":"NCT02497066","phase":"PHASE3","title":"Efficacy Study Comparing Compounded Topical Pain Creams vs. Placebo for Treating Pain Symptoms","status":"COMPLETED","sponsor":"Walter Reed National Military Medical Center","startDate":"2015-08-05","conditions":"Pain","enrollment":399},{"nctId":"NCT01890902","phase":"PHASE3","title":"Efficacy and Safety of Impracor (Ketoprofen 10% Cream) Compared With Placebo in the Treatment of Acute Pain (Flare) Associated With Osteoarthritis of the Knee","status":"WITHDRAWN","sponsor":"Imprimis Pharmaceuticals, Inc.","startDate":"2013-08","conditions":"Acute Pain (Flare) Associated With Osteoarthritis (OA) of the Knee","enrollment":""},{"nctId":"NCT00765700","phase":"PHASE3","title":"Ketoprofen 10% Cream for Treatment of Pain Associated With Mild to Moderate Acute Soft Tissue Injury","status":"COMPLETED","sponsor":"Imprimis Pharmaceuticals, Inc.","startDate":"2008-09","conditions":"Sprain, Strain, Acute Soft Tissue Injury","enrollment":364},{"nctId":"NCT01223053","phase":"PHASE3","title":"Ketoprofen 10% Cream for Treatment of Pain Associated With Mild to Moderate Acute Soft Tissue Injury","status":"WITHDRAWN","sponsor":"Imprimis Pharmaceuticals, Inc.","startDate":"","conditions":"Sprain","enrollment":""}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Ketotransdel (TDLP-110)"],"phase":"phase_3","status":"active","brandName":"Topical Ketoprofen 10% Cream","genericName":"Topical Ketoprofen 10% Cream","companyName":"Imprimis Pharmaceuticals, Inc.","companyId":"imprimis-pharmaceuticals-inc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis, thereby decreasing inflammation and pain at the site of topical application. Used for Topical treatment of musculoskeletal pain and inflammation, Localized joint and soft tissue pain.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}