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Topical Coal tar
Topical Coal tar is a Keratolytic and anti-inflammatory agent Small molecule drug developed by Post Graduate Institute of Medical Education and Research, Chandigarh. It is currently FDA-approved for Psoriasis, Eczema, Seborrheic dermatitis.
Coal tar works by reducing skin cell proliferation, decreasing inflammation, and providing antimicrobial and antipruritic effects on the skin surface.
Topical coal tar is used to treat various conditions, including Anal Intraepithelial Neoplasia (AIN) in HIV-infected patients, Vitiligo - Macular Depigmentation, Vulvar Lichen Sclerosus, and Androgenetic Alopecia, according to ClinicalTrials.gov. The exact mechanism of action of topical coal tar is unknown, as stated by ChEMBL.
At a glance
| Generic name | Topical Coal tar |
|---|---|
| Sponsor | Post Graduate Institute of Medical Education and Research, Chandigarh |
| Drug class | Keratolytic and anti-inflammatory agent |
| Modality | Small molecule |
| Therapeutic area | Dermatology |
| Phase | FDA-approved |
Mechanism of action
Coal tar is a complex mixture of hydrocarbons that penetrates the stratum corneum and reduces epidermal cell turnover, thereby slowing hyperkeratinization. It also possesses antimicrobial properties and reduces itching through local anesthetic effects. The exact molecular mechanisms are not fully elucidated but involve suppression of inflammatory mediators and normalization of abnormal keratinization patterns.
Approved indications
- Psoriasis
- Eczema
- Seborrheic dermatitis
- Lichen planus
- Pruritus
Common side effects
- Skin irritation
- Photosensitivity
- Staining of skin and clothing
- Folliculitis
- Contact dermatitis
Key clinical trials
- Durability of Three Monthly Loading Doses With Faricimab in Treatment-naïve Neovascular Age-related Macular Degeneration
- Topical Periplaneta Americana-Derived Meilian Fuxin Liquid for Radiation Dermatitis (PHASE2, PHASE3)
- Bladder Directed vs. Pelvic Floor Therapy in IC/BPS (PHASE2)
- Glyceryl Trinitrate Gel Phonophoresis on Planter Fasciiatis (NA)
- Clinical Trial to Demonstrate That the Dual Laser Therapy is Effective for the Treatment of Vulvar Lichen Sclerosus (NA)
- Vectored Thermal Pulsation, Intense Pulsed Light, and Eyelid Warm Compress Therapies for MGD (NA)
- Vitamin D Effects on Immune Microenvironment of Nonmelanoma Skin Cancer After Photodynamic Therapy (PDT) (NA)
- Efficacy of 0.5% Topical Timolol Eye Drops in the Treatment of Post-Inflammatory Erythema Following Acne Vulgaris (EARLY_PHASE1)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Topical Coal tar CI brief — competitive landscape report
- Topical Coal tar updates RSS · CI watch RSS
- Post Graduate Institute of Medical Education and Research, Chandigarh portfolio CI
Frequently asked questions about Topical Coal tar
What is Topical Coal tar?
How does Topical Coal tar work?
What is Topical Coal tar used for?
Who makes Topical Coal tar?
What drug class is Topical Coal tar in?
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What are the side effects of Topical Coal tar?
Related
- Drug class: All Keratolytic and anti-inflammatory agent drugs
- Manufacturer: Post Graduate Institute of Medical Education and Research, Chandigarh — full pipeline
- Therapeutic area: All drugs in Dermatology
- Indication: Drugs for Psoriasis
- Indication: Drugs for Eczema
- Indication: Drugs for Seborrheic dermatitis
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing