Last reviewed 2026-05-24 · How we verify

Tinoridine HCl

Takeda · FDA-approved active Small molecule ✓ Verified May 2026

Tinoridine HCl is a Non-steroidal anti-inflammatory drug (NSAID) Small molecule drug developed by Takeda. It is currently FDA-approved for Rheumatoid arthritis, Osteoarthritis, Inflammatory pain conditions. Also known as: Nonflamin.

Tinoridine HCl is a non-steroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase enzymes to reduce prostaglandin synthesis and inflammation.

Tinoridine HCl is a small molecule used in clinical trials to treat pain and inflammation in adults. It has been studied in comparison to a placebo in these trials.

At a glance

Generic name	Tinoridine HCl
Also known as	Nonflamin
Sponsor	Takeda
Drug class	Non-steroidal anti-inflammatory drug (NSAID)
Target	Cyclooxygenase (COX-1 and COX-2)
Modality	Small molecule
Therapeutic area	Rheumatology / Pain Management
Phase	FDA-approved

Mechanism of action

By blocking COX-1 and COX-2 enzymes, tinoridine reduces the production of prostaglandins, which are key mediators of inflammation, pain, and fever. This mechanism provides analgesic, anti-inflammatory, and antipyretic effects. The drug has been used primarily in Japan and some Asian markets for inflammatory and pain conditions.

Approved indications

Rheumatoid arthritis
Osteoarthritis
Inflammatory pain conditions

Common side effects

Gastrointestinal upset / dyspepsia
Abdominal pain
Nausea
Headache
Dizziness

Key clinical trials

Efficacy of Tinoridine in Treating Pain and Inflammation in Adults (PHASE4)

Primary sources

Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.

Source	Used for
ClinicalTrials.gov	Trial enrolment, design, endpoints, results

Competitive intelligence

For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:

Tinoridine HCl CI brief — competitive landscape report
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Takeda portfolio CI

Frequently asked questions about Tinoridine HCl

What is Tinoridine HCl?

Tinoridine HCl is a Non-steroidal anti-inflammatory drug (NSAID) drug developed by Takeda, indicated for Rheumatoid arthritis, Osteoarthritis, Inflammatory pain conditions.

How does Tinoridine HCl work?

Tinoridine HCl is a non-steroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase enzymes to reduce prostaglandin synthesis and inflammation.

What is Tinoridine HCl used for?

Tinoridine HCl is indicated for Rheumatoid arthritis, Osteoarthritis, Inflammatory pain conditions.

Who makes Tinoridine HCl?

Tinoridine HCl is developed and marketed by Takeda (see full Takeda pipeline at /company/takeda).

Is Tinoridine HCl also known as anything else?

Tinoridine HCl is also known as Nonflamin.

What drug class is Tinoridine HCl in?

Tinoridine HCl belongs to the Non-steroidal anti-inflammatory drug (NSAID) class. See all Non-steroidal anti-inflammatory drug (NSAID) drugs at /class/non-steroidal-anti-inflammatory-drug-nsaid.

What development phase is Tinoridine HCl in?

Tinoridine HCl is FDA-approved (marketed).

What are the side effects of Tinoridine HCl?

Common side effects of Tinoridine HCl include Gastrointestinal upset / dyspepsia, Abdominal pain, Nausea, Headache, Dizziness.

What does Tinoridine HCl target?

Tinoridine HCl targets Cyclooxygenase (COX-1 and COX-2) and is a Non-steroidal anti-inflammatory drug (NSAID).

Drug class: All Non-steroidal anti-inflammatory drug (NSAID) drugs
Target: All drugs targeting Cyclooxygenase (COX-1 and COX-2)
Manufacturer: Takeda — full pipeline
Therapeutic area: All drugs in Rheumatology / Pain Management
Indication: Drugs for Rheumatoid arthritis
Indication: Drugs for Osteoarthritis
Indication: Drugs for Inflammatory pain conditions
Also known as: Nonflamin

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing