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Tibolone plus Xiangshao granules
Tibolone acts as a selective tissue estrogenic activity regulator (STEAR) with progestin and androgen activity, while Xiangshao granules provide traditional Chinese medicine support for menopausal symptoms.
Tibolone acts as a selective tissue estrogenic activity regulator (STEAR) with progestin and androgen activity, while Xiangshao granules provide traditional Chinese medicine support for menopausal symptoms. Used for Menopausal symptoms (hot flashes, night sweats, vaginal atrophy), Osteoporosis prevention in postmenopausal women.
At a glance
| Generic name | Tibolone plus Xiangshao granules |
|---|---|
| Sponsor | Peking Union Medical College Hospital |
| Drug class | Hormone replacement therapy (HRT) / Selective tissue estrogenic activity regulator (STEAR) |
| Target | Estrogen receptor, Progesterone receptor, Androgen receptor |
| Modality | Small molecule |
| Therapeutic area | Gynecology / Endocrinology |
| Phase | FDA-approved |
Mechanism of action
Tibolone is a synthetic steroid that selectively activates estrogen, progesterone, and androgen receptors in target tissues, providing hormone replacement therapy benefits with a potentially improved safety profile compared to conventional HRT. Xiangshao granules are a traditional Chinese herbal formulation designed to complement hormonal therapy by addressing menopausal symptoms through herbal mechanisms. The combination aims to provide comprehensive symptom relief and hormonal support during menopause.
Approved indications
- Menopausal symptoms (hot flashes, night sweats, vaginal atrophy)
- Osteoporosis prevention in postmenopausal women
Common side effects
- Vaginal bleeding or spotting
- Breast tenderness
- Headache
- Nausea
Key clinical trials
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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