{"id":"tibolone-plus-xiangshao-granules","safety":{"commonSideEffects":[{"rate":null,"effect":"Vaginal bleeding or spotting"},{"rate":null,"effect":"Breast tenderness"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Nausea"}]},"_chembl":{"chemblId":"CHEMBL2103774","moleculeType":"Small molecule","molecularWeight":"312.45"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Tibolone is a synthetic steroid that selectively activates estrogen, progesterone, and androgen receptors in target tissues, providing hormone replacement therapy benefits with a potentially improved safety profile compared to conventional HRT. Xiangshao granules are a traditional Chinese herbal formulation designed to complement hormonal therapy by addressing menopausal symptoms through herbal mechanisms. The combination aims to provide comprehensive symptom relief and hormonal support during menopause.","oneSentence":"Tibolone acts as a selective tissue estrogenic activity regulator (STEAR) with progestin and androgen activity, while Xiangshao granules provide traditional Chinese medicine support for menopausal symptoms.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T00:12:36.217Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Menopausal symptoms (hot flashes, night sweats, vaginal atrophy)"},{"name":"Osteoporosis prevention in postmenopausal women"}]},"trialDetails":[{"nctId":"NCT06117969","phase":"PHASE4","title":"the Effects of Different Therapy Regimens on Menopausal Sleep Disorders","status":"UNKNOWN","sponsor":"Peking Union Medical College Hospital","startDate":"2023-12-30","conditions":"Menopause, Sleep Disorder","enrollment":180}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Tibolone plus Xiangshao granules","genericName":"Tibolone plus Xiangshao granules","companyName":"Peking Union Medical College Hospital","companyId":"peking-union-medical-college-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Tibolone acts as a selective tissue estrogenic activity regulator (STEAR) with progestin and androgen activity, while Xiangshao granules provide traditional Chinese medicine support for menopausal symptoms. Used for Menopausal symptoms (hot flashes, night sweats, vaginal atrophy), Osteoporosis prevention in postmenopausal women.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}