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thyroid hormone and folinic acid
This combination replaces deficient thyroid hormone while folinic acid (leucovorin) supports cellular methylation and one-carbon metabolism, potentially addressing metabolic and neurological dysfunction.
This combination replaces deficient thyroid hormone while folinic acid (leucovorin) supports cellular methylation and one-carbon metabolism, potentially addressing metabolic and neurological dysfunction. Used for Down syndrome (trisomy 21) — developmental and metabolic support.
At a glance
| Generic name | thyroid hormone and folinic acid |
|---|---|
| Sponsor | Institut Jerome Lejeune |
| Drug class | Hormone replacement and vitamin supplement combination |
| Target | Thyroid hormone receptors (TR-α, TR-β); folate metabolism enzymes |
| Modality | Small molecule |
| Therapeutic area | Endocrinology / Neurodevelopmental disorders |
| Phase | Phase 3 |
Mechanism of action
Thyroid hormone (levothyroxine or similar) restores thyroid function and metabolic rate in hypothyroid states. Folinic acid is a reduced form of folic acid that bypasses enzymatic conversion and directly supports one-carbon transfer reactions critical for DNA synthesis, methylation, and neurotransmitter production. The combination may be designed to address both thyroid insufficiency and folate-dependent metabolic pathways implicated in developmental or neurological conditions.
Approved indications
- Down syndrome (trisomy 21) — developmental and metabolic support
Common side effects
- Thyroid hormone-related: tachycardia
- Thyroid hormone-related: tremor
- Thyroid hormone-related: anxiety
- Folinic acid-related: gastrointestinal upset
Key clinical trials
- Frequency of Fibromyalgia Syndrome in Elderly Patients Aged 80 and Above and Its Relationship With Geriatric Parameters
- Speech-Based Artificial Intelligence for Detection of Dementia in Danish Patients
- Relative Energy Deficiency in Sport and Dance
- Characteristics of Anemia in Celiac Disease
- Efficacy Assessment of Systematic Treatment With Folinic Acid and Thyroid Hormone on Psychomotor Development of Down Syndrome Young Children (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
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- thyroid hormone and folinic acid CI brief — competitive landscape report
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- Institut Jerome Lejeune portfolio CI