{"id":"thyroid-hormone-and-folinic-acid","safety":{"commonSideEffects":[{"rate":null,"effect":"Thyroid hormone-related: tachycardia"},{"rate":null,"effect":"Thyroid hormone-related: tremor"},{"rate":null,"effect":"Thyroid hormone-related: anxiety"},{"rate":null,"effect":"Folinic acid-related: gastrointestinal upset"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"anthropic-haiku","explanation":"Thyroid hormone (levothyroxine or similar) restores thyroid function and metabolic rate in hypothyroid states. Folinic acid is a reduced form of folic acid that bypasses enzymatic conversion and directly supports one-carbon transfer reactions critical for DNA synthesis, methylation, and neurotransmitter production. The combination may be designed to address both thyroid insufficiency and folate-dependent metabolic pathways implicated in developmental or neurological conditions.","oneSentence":"This combination replaces deficient thyroid hormone while folinic acid (leucovorin) supports cellular methylation and one-carbon metabolism, potentially addressing metabolic and neurological dysfunction.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:54:10.046Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Down syndrome (trisomy 21) — developmental and metabolic support"}]},"trialDetails":[{"nctId":"NCT06969716","phase":"","title":"Frequency of Fibromyalgia Syndrome in Elderly Patients Aged 80 and Above and Its Relationship With Geriatric Parameters","status":"COMPLETED","sponsor":"Sultan 1. Murat State Hospital","startDate":"2025-05-01","conditions":"Fibromyalgia, Old Age; Debility","enrollment":420},{"nctId":"NCT07200739","phase":"","title":"Speech-Based Artificial Intelligence for Detection of Dementia in Danish Patients","status":"ENROLLING_BY_INVITATION","sponsor":"Zealand University Hospital","startDate":"2025-10-01","conditions":"Dementia (Diagnosis), Alzheimer Dementia (AD), Vascular Dementia (VaD)","enrollment":340},{"nctId":"NCT06480682","phase":"","title":"Relative Energy Deficiency in Sport and Dance","status":"NOT_YET_RECRUITING","sponsor":"University of Wolverhampton","startDate":"2024-09-10","conditions":"Relative Energy Deficiency in Sport, Bone Stress Reaction","enrollment":200},{"nctId":"NCT05172895","phase":"","title":"Characteristics of Anemia in Celiac Disease","status":"COMPLETED","sponsor":"University of Palermo","startDate":"2001-01-01","conditions":"Celiac Disease","enrollment":159},{"nctId":"NCT01576705","phase":"PHASE3","title":"Efficacy Assessment of Systematic Treatment With Folinic Acid and Thyroid Hormone on Psychomotor Development of Down Syndrome Young Children","status":"COMPLETED","sponsor":"Institut Jerome Lejeune","startDate":"2012-04-02","conditions":"Down Syndrome","enrollment":175}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"thyroid hormone and folinic acid","genericName":"thyroid hormone and folinic acid","companyName":"Institut Jerome Lejeune","companyId":"institut-jerome-lejeune","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This combination replaces deficient thyroid hormone while folinic acid (leucovorin) supports cellular methylation and one-carbon metabolism, potentially addressing metabolic and neurological dysfunction. Used for Down syndrome (trisomy 21) — developmental and metabolic support.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}