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The ropivacaine group
The ropivacaine group is a Local anesthetic (amide) Small molecule drug developed by Beijing Tiantan Hospital. It is currently FDA-approved for Local and regional anesthesia for surgery and acute pain management, Peripheral nerve blocks, Epidural anesthesia.
Ropivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of action potentials.
Ropivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of action potentials. Used for Local and regional anesthesia for surgery and acute pain management, Peripheral nerve blocks, Epidural anesthesia.
At a glance
| Generic name | The ropivacaine group |
|---|---|
| Sponsor | Beijing Tiantan Hospital |
| Drug class | Local anesthetic (amide) |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesia / Pain Management |
| Phase | FDA-approved |
Mechanism of action
Ropivacaine reversibly inhibits sodium influx into nerve fibers, which stabilizes the neuronal membrane and prevents depolarization. This action blocks conduction of sensory, motor, and autonomic nerve impulses in a dose-dependent manner. It is an amide-type local anesthetic with a long duration of action and lower cardiotoxicity compared to some other local anesthetics.
Approved indications
- Local and regional anesthesia for surgery and acute pain management
- Peripheral nerve blocks
- Epidural anesthesia
Common side effects
- Hypotension
- Bradycardia
- Nausea
- Headache
- Dizziness
- Systemic toxicity (CNS and cardiac effects at high doses)
Key clinical trials
- OMT for Adhesive Capsulitis (PHASE4)
- A Clinical Trial Evaluating the Efficacy, Safety, and Pharmacokinetic Profile of TRD303 for Postoperative Analgesia After Abdominal Surgery in China. (PHASE3)
- Pericapsular Nerve Group (PENG) Block Combined With Lateral Femoral Cutaneous Nerve (LFCN) Block or Wound Infiltration for Postoperative Analgesia in Anterior Approach Total Hip Arthroplasty: A Randomized Controlled Trial (NA)
- Does the Common Practice of Adding Diluted Epinephrine in Tranverse Abdominal Plan Block to Ropivacaine Significantly Decrease the Peak Systemic Resorption of Ropivacaine? (NA)
- The Effects of Various Concentrations of Ropivacaine on the Onset and Duration of Ankle Blocks (NA)
- Integrative Bilateral Cervical Sympathetic Blocks for Trauma-Related Symptoms in Special Operations Veterans: A Prospective Case Series
- Erector Spinae Plane Block for Pain Control After Open Abdominal Surgery (NA)
- PUSHES (Pudendal Block Versus Sacral ESP Hemorrhoidectomy Study) (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- The ropivacaine group CI brief — competitive landscape report
- The ropivacaine group updates RSS · CI watch RSS
- Beijing Tiantan Hospital portfolio CI
Frequently asked questions about The ropivacaine group
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Related
- Drug class: All Local anesthetic (amide) drugs
- Target: All drugs targeting Voltage-gated sodium channels
- Manufacturer: Beijing Tiantan Hospital — full pipeline
- Therapeutic area: All drugs in Anesthesia / Pain Management
- Indication: Drugs for Local and regional anesthesia for surgery and acute pain management
- Indication: Drugs for Peripheral nerve blocks
- Indication: Drugs for Epidural anesthesia