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terbutaline sulfate (Bricasol)
Terbutaline sulfate is a beta-2 adrenergic receptor agonist that stimulates bronchial smooth muscle relaxation to improve airway patency and breathing.
Terbutaline sulfate is a beta-2 adrenergic receptor agonist that stimulates bronchial smooth muscle relaxation to improve airway patency and breathing. Used for Asthma (acute bronchospasm relief and maintenance therapy), Chronic obstructive pulmonary disease (COPD) with reversible airflow obstruction.
At a glance
| Generic name | terbutaline sulfate (Bricasol) |
|---|---|
| Also known as | Bricasol pMDI |
| Sponsor | AstraZeneca |
| Drug class | Beta-2 adrenergic agonist (short-acting bronchodilator) |
| Target | Beta-2 adrenergic receptor (ADRB2) |
| Modality | Small molecule |
| Therapeutic area | Respiratory |
| Phase | Phase 3 |
Mechanism of action
Terbutaline binds to beta-2 adrenergic receptors on airway smooth muscle, activating intracellular signaling cascades that increase cAMP levels and promote smooth muscle relaxation. This bronchodilation effect rapidly opens constricted airways, improving airflow and reducing respiratory symptoms in obstructive airway diseases. The drug is selective for beta-2 receptors, minimizing systemic cardiovascular effects compared to non-selective beta agonists.
Approved indications
- Asthma (acute bronchospasm relief and maintenance therapy)
- Chronic obstructive pulmonary disease (COPD) with reversible airflow obstruction
Common side effects
- Tremor
- Nervousness or anxiety
- Headache
- Palpitations
- Tachycardia
- Muscle cramps
Key clinical trials
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- terbutaline sulfate (Bricasol) CI brief — competitive landscape report
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- AstraZeneca portfolio CI