{"id":"terbutaline-sulfate-bricasol","safety":{"commonSideEffects":[{"rate":"10-15","effect":"Tremor"},{"rate":"5-10","effect":"Nervousness or anxiety"},{"rate":"5-10","effect":"Headache"},{"rate":"3-5","effect":"Palpitations"},{"rate":"3-5","effect":"Tachycardia"},{"rate":"2-5","effect":"Muscle cramps"}]},"_chembl":{"chemblId":"CHEMBL1315867","moleculeType":"Small molecule","molecularWeight":"548.66"},"_dailymed":null,"mechanism":{"_ai_source":"anthropic-haiku","explanation":"Terbutaline binds to beta-2 adrenergic receptors on airway smooth muscle, activating intracellular signaling cascades that increase cAMP levels and promote smooth muscle relaxation. This bronchodilation effect rapidly opens constricted airways, improving airflow and reducing respiratory symptoms in obstructive airway diseases. The drug is selective for beta-2 receptors, minimizing systemic cardiovascular effects compared to non-selective beta agonists.","oneSentence":"Terbutaline sulfate is a beta-2 adrenergic receptor agonist that stimulates bronchial smooth muscle relaxation to improve airway patency and breathing.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:38:07.166Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Asthma (acute bronchospasm relief and maintenance therapy)"},{"name":"Chronic obstructive pulmonary disease (COPD) with reversible airflow obstruction"}]},"trialDetails":[{"nctId":"NCT00421122","phase":"PHASE3","title":"Efficacy and Safety Study of Symbicort Turbuhaler in Chinese Patients With COPD","status":"COMPLETED","sponsor":"AstraZeneca","startDate":"2006-09","conditions":"Chronic Obstructive Pulmonary Disease","enrollment":315}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Bricasol pMDI"],"phase":"phase_3","status":"active","brandName":"terbutaline sulfate (Bricasol)","genericName":"terbutaline sulfate (Bricasol)","companyName":"AstraZeneca","companyId":"astrazeneca","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Terbutaline sulfate is a beta-2 adrenergic receptor agonist that stimulates bronchial smooth muscle relaxation to improve airway patency and breathing. Used for Asthma (acute bronchospasm relief and maintenance therapy), Chronic obstructive pulmonary disease (COPD) with reversible airflow obstruction.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}