Last reviewed · How we verify
tenofovir + abacavir + lopinavir/ritonavir
tenofovir + abacavir + lopinavir/ritonavir is a Antiretroviral combination therapy (NRTI + PI/boosted) Small molecule drug developed by Hospital Clinic of Barcelona. It is currently FDA-approved for HIV-1 infection.
This combination inhibits HIV reverse transcriptase and protease to suppress viral replication.
This combination inhibits HIV reverse transcriptase and protease to suppress viral replication. Used for HIV-1 infection.
At a glance
| Generic name | tenofovir + abacavir + lopinavir/ritonavir |
|---|---|
| Sponsor | Hospital Clinic of Barcelona |
| Drug class | Antiretroviral combination therapy (NRTI + PI/boosted) |
| Target | HIV reverse transcriptase, HIV protease |
| Modality | Small molecule |
| Therapeutic area | Infectious Disease / Virology |
| Phase | FDA-approved |
Mechanism of action
Tenofovir and abacavir are nucleotide/nucleoside reverse transcriptase inhibitors that block HIV reverse transcriptase, preventing viral RNA conversion to DNA. Lopinavir/ritonavir is a protease inhibitor combination where ritonavir boosts lopinavir levels by inhibiting its metabolism, allowing lopinavir to block HIV protease and prevent viral maturation. Together, they suppress HIV replication through multiple mechanisms.
Approved indications
- HIV-1 infection
Common side effects
- Diarrhea
- Nausea
- Abdominal pain
- Headache
- Lipid abnormalities (elevated cholesterol/triglycerides)
- Lactic acidosis
- Hepatotoxicity
Key clinical trials
- Study of Cobicistat-Boosted Atazanavir (ATV/co), Cobicistat-Boosted Darunavir (DRV/co) and Emtricitabine/Tenofovir Alafenamide (F/TAF) in Children With HIV (PHASE2, PHASE3)
- A Study to Provide Continued Access to Study Drug to Children and Adolescents Who Have Completed Clinical Studies Involving Gilead HIV Treatments (PHASE4)
- Pharmacokinetic Study of Antiretroviral Drugs and Related Drugs During and After Pregnancy
- Research on the Psychological Status of Patients With HIV-1 Infection
- Anti-HIV Drug Regimens and Treatment-Switching Guidelines in HIV Infected Children (PHASE2, PHASE3)
- A Comparison of Two Anti-HIV Drug Regimens for Youth Who Have Failed Prior Therapy (PHASE2)
- Study to Evaluate Switching From a Regimen of Two Nucleos(t)Ide Reverse Transcriptase Inhibitors (NRTI) Plus a Third Agent to a Fixed Dose Combination (FDC) of Bictegravir/Emtricitabine/Tenofovir Alafenamide (B/F/TAF), in Virologically-Suppressed, HIV-1 Infected African American Participants (PHASE3)
- Study of Options for Second-Line Effective Combination Therapy (SELECT) (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- tenofovir + abacavir + lopinavir/ritonavir CI brief — competitive landscape report
- tenofovir + abacavir + lopinavir/ritonavir updates RSS · CI watch RSS
- Hospital Clinic of Barcelona portfolio CI
Frequently asked questions about tenofovir + abacavir + lopinavir/ritonavir
What is tenofovir + abacavir + lopinavir/ritonavir?
How does tenofovir + abacavir + lopinavir/ritonavir work?
What is tenofovir + abacavir + lopinavir/ritonavir used for?
Who makes tenofovir + abacavir + lopinavir/ritonavir?
What drug class is tenofovir + abacavir + lopinavir/ritonavir in?
What development phase is tenofovir + abacavir + lopinavir/ritonavir in?
What are the side effects of tenofovir + abacavir + lopinavir/ritonavir?
What does tenofovir + abacavir + lopinavir/ritonavir target?
Related
- Drug class: All Antiretroviral combination therapy (NRTI + PI/boosted) drugs
- Target: All drugs targeting HIV reverse transcriptase, HIV protease
- Manufacturer: Hospital Clinic of Barcelona — full pipeline
- Therapeutic area: All drugs in Infectious Disease / Virology
- Indication: Drugs for HIV-1 infection
- Compare: tenofovir + abacavir + lopinavir/ritonavir vs similar drugs
- Pricing: tenofovir + abacavir + lopinavir/ritonavir cost, discount & access