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Technetium Tc99m Tetrofosmin injections
Technetium Tc99m Tetrofosmin injections is a Myocardial perfusion imaging agent Small molecule drug developed by GE Healthcare. It is currently FDA-approved for Acute coronary syndrome and myocardial infarction imaging, Coronary artery disease detection via stress testing, Myocardial viability assessment.
Technetium Tc99m Tetrofosmin is a lipophilic cationic complex that accumulates in viable myocardial tissue based on blood flow and mitochondrial membrane potential, allowing visualization of myocardial perfusion.
Technetium Tc99m Tetrofosmin is a lipophilic cationic complex that accumulates in viable myocardial tissue based on blood flow and mitochondrial membrane potential, allowing visualization of myocardial perfusion. Used for Acute coronary syndrome and myocardial infarction imaging, Coronary artery disease detection via stress testing, Myocardial viability assessment.
At a glance
| Generic name | Technetium Tc99m Tetrofosmin injections |
|---|---|
| Sponsor | GE Healthcare |
| Drug class | Myocardial perfusion imaging agent |
| Target | Mitochondrial membrane potential in myocardial cells |
| Modality | Small molecule |
| Therapeutic area | Cardiovascular |
| Phase | FDA-approved |
Mechanism of action
The tetrofosmin molecule is a small lipophilic cationic agent labeled with Tc99m that crosses cell membranes and localizes in mitochondria of viable myocardial cells. Uptake is proportional to myocardial blood flow and cellular viability, enabling detection of perfusion defects and ischemic regions. The agent is used as a radiotracer in nuclear imaging to assess coronary artery disease and myocardial viability.
Approved indications
- Acute coronary syndrome and myocardial infarction imaging
- Coronary artery disease detection via stress testing
- Myocardial viability assessment
Common side effects
- Headache
- Dizziness
- Chest discomfort (stress-related)
- Hypersensitivity reactions
Key clinical trials
- A Study of Regadenoson in Subjects Undergoing Stress Myocardial Perfusion Imaging (MPI) Using Multidetector Computed Tomography (MDCT) Compared to Single Photon Emission Computed Tomography (SPECT) (PHASE2)
- Caffeine's Effect on Regadenoson Administration With Single Photon Emission Computed Tomography (SPECT) Myocardial Perfusion Imaging (MPI) (PHASE3)
- A Phase 3 Multi-center Study to Assess PET Imaging of Flurpiridaz F 18 Injection in Patients With CAD. (PHASE3)
- Anti-gravity Treadmill Exercise in Stress Myocardial Perfusion Imaging (NA)
- Comparison of Diagnostic Rest/Stress SPECT Results for Patients With Myocardial Ischemia and Infarction Using Myoview in Both Single and Dual Isotope Acquisition Approaches (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Technetium Tc99m Tetrofosmin injections CI brief — competitive landscape report
- Technetium Tc99m Tetrofosmin injections updates RSS · CI watch RSS
- GE Healthcare portfolio CI
Frequently asked questions about Technetium Tc99m Tetrofosmin injections
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Related
- Drug class: All Myocardial perfusion imaging agent drugs
- Target: All drugs targeting Mitochondrial membrane potential in myocardial cells
- Manufacturer: GE Healthcare — full pipeline
- Therapeutic area: All drugs in Cardiovascular
- Indication: Drugs for Acute coronary syndrome and myocardial infarction imaging
- Indication: Drugs for Coronary artery disease detection via stress testing
- Indication: Drugs for Myocardial viability assessment
- Compare: Technetium Tc99m Tetrofosmin injections vs similar drugs
- Pricing: Technetium Tc99m Tetrofosmin injections cost, discount & access