{"id":"technetium-tc99m-tetrofosmin-injections","safety":{"commonSideEffects":[{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Chest discomfort (stress-related)"},{"rate":null,"effect":"Hypersensitivity reactions"}]},"_chembl":{"chemblId":"CHEMBL1200857","moleculeType":"Small molecule","molecularWeight":"481.37"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The tetrofosmin molecule is a small lipophilic cationic agent labeled with Tc99m that crosses cell membranes and localizes in mitochondria of viable myocardial cells. Uptake is proportional to myocardial blood flow and cellular viability, enabling detection of perfusion defects and ischemic regions. The agent is used as a radiotracer in nuclear imaging to assess coronary artery disease and myocardial viability.","oneSentence":"Technetium Tc99m Tetrofosmin is a lipophilic cationic complex that accumulates in viable myocardial tissue based on blood flow and mitochondrial membrane potential, allowing visualization of myocardial perfusion.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:38:25.279Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute coronary syndrome and myocardial infarction imaging"},{"name":"Coronary artery disease detection via stress testing"},{"name":"Myocardial viability assessment"}]},"trialDetails":[{"nctId":"NCT01334918","phase":"PHASE2","title":"A Study of Regadenoson in Subjects Undergoing Stress Myocardial Perfusion Imaging (MPI) Using Multidetector Computed Tomography (MDCT) Compared to Single Photon Emission Computed Tomography (SPECT)","status":"COMPLETED","sponsor":"Astellas Pharma Inc","startDate":"2011-04-26","conditions":"Coronary Artery Disease (CAD)","enrollment":124},{"nctId":"NCT00826280","phase":"PHASE3","title":"Caffeine's Effect on Regadenoson Administration With Single Photon Emission Computed Tomography (SPECT) Myocardial Perfusion Imaging (MPI)","status":"COMPLETED","sponsor":"Astellas Pharma Inc","startDate":"2009-03-24","conditions":"Coronary Artery Disease (CAD)","enrollment":347},{"nctId":"NCT01347710","phase":"PHASE3","title":"A Phase 3 Multi-center Study to Assess PET Imaging of Flurpiridaz F 18 Injection in Patients With CAD.","status":"COMPLETED","sponsor":"Lantheus Medical Imaging","startDate":"2011-06","conditions":"Coronary Artery Disease","enrollment":795},{"nctId":"NCT02628002","phase":"NA","title":"Anti-gravity Treadmill Exercise in Stress Myocardial Perfusion Imaging","status":"COMPLETED","sponsor":"University of Cincinnati","startDate":"2015-12","conditions":"Coronary Artery Disease","enrollment":49},{"nctId":"NCT00381316","phase":"PHASE4","title":"Comparison of Diagnostic Rest/Stress SPECT Results for Patients With Myocardial Ischemia and Infarction Using Myoview in Both Single and Dual Isotope Acquisition Approaches","status":"COMPLETED","sponsor":"GE Healthcare","startDate":"2006-07","conditions":"Coronary Artery Disease","enrollment":291}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":23,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Technetium Tc99m Tetrofosmin injections","genericName":"Technetium Tc99m Tetrofosmin injections","companyName":"GE Healthcare","companyId":"ge-healthcare","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Technetium Tc99m Tetrofosmin is a lipophilic cationic complex that accumulates in viable myocardial tissue based on blood flow and mitochondrial membrane potential, allowing visualization of myocardial perfusion. Used for Acute coronary syndrome and myocardial infarction imaging, Coronary artery disease detection via stress testing, Myocardial viability assessment.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}