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Tamsulosin and Tadalafil

Fayoum University Hospital · FDA-approved active Small molecule

Tamsulosin and Tadalafil is a Alpha-1A adrenergic antagonist and phosphodiesterase-5 inhibitor combination Small molecule drug developed by Fayoum University Hospital. It is currently FDA-approved for Benign prostatic hyperplasia with lower urinary tract symptoms, Erectile dysfunction associated with benign prostatic hyperplasia. Also known as: Group C.

Tamsulosin selectively blocks alpha-1A adrenergic receptors in the prostate to relax smooth muscle, while tadalafil inhibits phosphodiesterase-5 to increase cGMP and improve erectile function and lower urinary tract symptoms.

Tamsulosin selectively blocks alpha-1A adrenergic receptors in the prostate to relax smooth muscle, while tadalafil inhibits phosphodiesterase-5 to increase cGMP and improve erectile function and lower urinary tract symptoms. Used for Benign prostatic hyperplasia with lower urinary tract symptoms, Erectile dysfunction associated with benign prostatic hyperplasia.

At a glance

Generic nameTamsulosin and Tadalafil
Also known asGroup C
SponsorFayoum University Hospital
Drug classAlpha-1A adrenergic antagonist and phosphodiesterase-5 inhibitor combination
TargetAlpha-1A adrenergic receptor; phosphodiesterase-5 (PDE-5)
ModalitySmall molecule
Therapeutic areaUrology
PhaseFDA-approved

Mechanism of action

Tamsulosin is an alpha-1A selective antagonist that reduces smooth muscle tone in the prostate and bladder neck, improving urine flow and reducing lower urinary tract symptoms in benign prostatic hyperplasia. Tadalafil is a phosphodiesterase-5 inhibitor that enhances nitric oxide signaling, increasing cGMP levels to relax smooth muscle in the corpus cavernosum and lower urinary tract tissues, improving erectile function and LUTS. The combination addresses both erectile dysfunction and benign prostatic hyperplasia symptoms.

Approved indications

Common side effects

Key clinical trials

Primary sources

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SourceUsed for
ClinicalTrials.govTrial enrolment, design, endpoints, results

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Frequently asked questions about Tamsulosin and Tadalafil

What is Tamsulosin and Tadalafil?

Tamsulosin and Tadalafil is a Alpha-1A adrenergic antagonist and phosphodiesterase-5 inhibitor combination drug developed by Fayoum University Hospital, indicated for Benign prostatic hyperplasia with lower urinary tract symptoms, Erectile dysfunction associated with benign prostatic hyperplasia.

How does Tamsulosin and Tadalafil work?

Tamsulosin selectively blocks alpha-1A adrenergic receptors in the prostate to relax smooth muscle, while tadalafil inhibits phosphodiesterase-5 to increase cGMP and improve erectile function and lower urinary tract symptoms.

What is Tamsulosin and Tadalafil used for?

Tamsulosin and Tadalafil is indicated for Benign prostatic hyperplasia with lower urinary tract symptoms, Erectile dysfunction associated with benign prostatic hyperplasia.

Who makes Tamsulosin and Tadalafil?

Tamsulosin and Tadalafil is developed and marketed by Fayoum University Hospital (see full Fayoum University Hospital pipeline at /company/fayoum-university-hospital).

Is Tamsulosin and Tadalafil also known as anything else?

Tamsulosin and Tadalafil is also known as Group C.

What drug class is Tamsulosin and Tadalafil in?

Tamsulosin and Tadalafil belongs to the Alpha-1A adrenergic antagonist and phosphodiesterase-5 inhibitor combination class. See all Alpha-1A adrenergic antagonist and phosphodiesterase-5 inhibitor combination drugs at /class/alpha-1a-adrenergic-antagonist-and-phosphodiesterase-5-inhibitor-combination.

What development phase is Tamsulosin and Tadalafil in?

Tamsulosin and Tadalafil is FDA-approved (marketed).

What are the side effects of Tamsulosin and Tadalafil?

Common side effects of Tamsulosin and Tadalafil include Headache, Dizziness, Dyspepsia, Nasal congestion, Back pain, Orthostatic hypotension.

What does Tamsulosin and Tadalafil target?

Tamsulosin and Tadalafil targets Alpha-1A adrenergic receptor; phosphodiesterase-5 (PDE-5) and is a Alpha-1A adrenergic antagonist and phosphodiesterase-5 inhibitor combination.

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