Last reviewed 2026-05-23 · How we verify

Systane Hydration PF

University of Alabama at Birmingham · FDA-approved active Small molecule ✓ Verified May 2026

Systane Hydration PF is a Artificial tear / Ocular lubricant Small molecule drug developed by University of Alabama at Birmingham. It is currently FDA-approved for Dry eye disease / Keratoconjunctivitis sicca.

Systane Hydration PF is an artificial tear solution that lubricates and hydrates the ocular surface to relieve dry eye symptoms.

Systane Hydration PF is a small molecule preservative-free solution used to treat dry eye. It is a combination of polyethylene glycol 400 and propylene glycol, as indicated by its use in clinical trials for dry eye conditions.

At a glance

Generic name	Systane Hydration PF
Sponsor	University of Alabama at Birmingham
Drug class	Artificial tear / Ocular lubricant
Modality	Small molecule
Therapeutic area	Ophthalmology
Phase	FDA-approved

Mechanism of action

This preservative-free (PF) ophthalmic solution provides moisture and lubrication to the cornea and conjunctiva, mimicking natural tears to reduce friction and irritation. It helps stabilize the tear film and protect the ocular surface in patients with dry eye disease or keratoconjunctivitis sicca.

Approved indications

Dry eye disease / Keratoconjunctivitis sicca

Common side effects

Ocular irritation
Blurred vision
Eye discomfort

Key clinical trials

Primary sources

Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.

Source	Used for
ClinicalTrials.gov	Trial enrolment, design, endpoints, results

Competitive intelligence

For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:

Systane Hydration PF CI brief — competitive landscape report
Systane Hydration PF updates RSS · CI watch RSS
University of Alabama at Birmingham portfolio CI

Frequently asked questions about Systane Hydration PF

What is Systane Hydration PF?

Systane Hydration PF is a Artificial tear / Ocular lubricant drug developed by University of Alabama at Birmingham, indicated for Dry eye disease / Keratoconjunctivitis sicca.

How does Systane Hydration PF work?

Systane Hydration PF is an artificial tear solution that lubricates and hydrates the ocular surface to relieve dry eye symptoms.

What is Systane Hydration PF used for?

Systane Hydration PF is indicated for Dry eye disease / Keratoconjunctivitis sicca.

Who makes Systane Hydration PF?

Systane Hydration PF is developed and marketed by University of Alabama at Birmingham (see full University of Alabama at Birmingham pipeline at /company/university-of-alabama-at-birmingham).

What drug class is Systane Hydration PF in?

Systane Hydration PF belongs to the Artificial tear / Ocular lubricant class. See all Artificial tear / Ocular lubricant drugs at /class/artificial-tear-ocular-lubricant.

What development phase is Systane Hydration PF in?

Systane Hydration PF is FDA-approved (marketed).

What are the side effects of Systane Hydration PF?

Common side effects of Systane Hydration PF include Ocular irritation, Blurred vision, Eye discomfort.

Drug class: All Artificial tear / Ocular lubricant drugs
Manufacturer: University of Alabama at Birmingham — full pipeline
Therapeutic area: All drugs in Ophthalmology
Indication: Drugs for Dry eye disease / Keratoconjunctivitis sicca

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing