{"id":"systane-hydration-pf","safety":{"commonSideEffects":[{"rate":null,"effect":"Ocular irritation"},{"rate":null,"effect":"Blurred vision"},{"rate":null,"effect":"Eye discomfort"}]},"_chembl":{"chemblId":"CHEMBL484929","moleculeType":"Small molecule","molecularWeight":"452.29"},"_dailymed":{"setId":"8936f66f-10fe-44ab-a26e-dd8b05dfa997","title":"SYSTANE HYDRATION PF PRESERVATIVE FREE (POLYETHYLENE GLYCOL 400 AND PROPYLENE GLYCOL) SOLUTION/ DROPS [ALCON LABORATORIES, INC.]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This preservative-free (PF) ophthalmic solution provides moisture and lubrication to the cornea and conjunctiva, mimicking natural tears to reduce friction and irritation. It helps stabilize the tear film and protect the ocular surface in patients with dry eye disease or keratoconjunctivitis sicca.","oneSentence":"Systane Hydration PF is an artificial tear solution that lubricates and hydrates the ocular surface to relieve dry eye symptoms.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:10:30.490Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Dry eye disease / Keratoconjunctivitis sicca"}]},"trialDetails":[{"nctId":"NCT05932238","phase":"NA","title":"Systane® Hydration PF and Systane® Hydration Preserved","status":"COMPLETED","sponsor":"Alcon Research","startDate":"2023-10-06","conditions":"Dry Eye","enrollment":137},{"nctId":"NCT04837807","phase":"PHASE4","title":"Digital Device Users Who Are Treated With Systane Hydration PF","status":"COMPLETED","sponsor":"University of Alabama at Birmingham","startDate":"2021-08-18","conditions":"Dry Eye","enrollment":30}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Systane Hydration PF","genericName":"Systane Hydration PF","companyName":"University of Alabama at Birmingham","companyId":"university-of-alabama-at-birmingham","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Systane Hydration PF is a small molecule preservative-free solution used to treat dry eye. It is a combination of polyethylene glycol 400 and propylene glycol, as indicated by its use in clinical trials for dry eye conditions.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}