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Synthetic Vitamin B1
Synthetic Vitamin B1 (thiamine) acts as a coenzyme in carbohydrate metabolism and nervous system function.
Synthetic Vitamin B1 (thiamine) acts as a coenzyme in carbohydrate metabolism and nervous system function. Used for Thiamine deficiency (beriberi), Wernicke-Korsakoff syndrome, Thiamine supplementation in alcoholism and malnutrition.
At a glance
| Generic name | Synthetic Vitamin B1 |
|---|---|
| Sponsor | ClinAmygate |
| Drug class | Vitamin B1 (thiamine) supplement |
| Target | Thiamine pyrophosphokinase (enzyme target for activation); functions as cofactor for multiple metabolic enzymes |
| Modality | Small molecule |
| Therapeutic area | Nutritional/Metabolic; Neurology |
| Phase | FDA-approved |
Mechanism of action
Thiamine is converted to thiamine pyrophosphate (TPP), which serves as an essential cofactor for several key enzymes involved in carbohydrate metabolism (pyruvate dehydrogenase, α-ketoglutarate dehydrogenase) and transketolase reactions. It is critical for energy production in cells and proper neurological function, particularly in the peripheral and central nervous systems.
Approved indications
- Thiamine deficiency (beriberi)
- Wernicke-Korsakoff syndrome
- Thiamine supplementation in alcoholism and malnutrition
- Peripheral neuropathy associated with thiamine deficiency
Common side effects
- Hypersensitivity reactions (rare)
- Local injection site reactions (if parenteral)
- Generally well-tolerated with minimal adverse effects
Key clinical trials
- Post-COVID-19 Chronic Fatigue Syndrome (PHASE4)
- Comparison Between Oxycodone and Pregabalin as Preemptive Analgesia (PHASE2, PHASE3)
- Natural Versus Synthetic Vitamin B Complexes in Human (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Synthetic Vitamin B1 CI brief — competitive landscape report
- Synthetic Vitamin B1 updates RSS · CI watch RSS
- ClinAmygate portfolio CI