{"id":"synthetic-vitamin-b1","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypersensitivity reactions (rare)"},{"rate":null,"effect":"Local injection site reactions (if parenteral)"},{"rate":null,"effect":"Generally well-tolerated with minimal adverse effects"}]},"_chembl":{"chemblId":"CHEMBL1201467","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Thiamine is converted to thiamine pyrophosphate (TPP), which serves as an essential cofactor for several key enzymes involved in carbohydrate metabolism (pyruvate dehydrogenase, α-ketoglutarate dehydrogenase) and transketolase reactions. It is critical for energy production in cells and proper neurological function, particularly in the peripheral and central nervous systems.","oneSentence":"Synthetic Vitamin B1 (thiamine) acts as a coenzyme in carbohydrate metabolism and nervous system function.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:38:17.635Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Thiamine deficiency (beriberi)"},{"name":"Wernicke-Korsakoff syndrome"},{"name":"Thiamine supplementation in alcoholism and malnutrition"},{"name":"Peripheral neuropathy associated with thiamine deficiency"}]},"trialDetails":[{"nctId":"NCT05642923","phase":"PHASE4","title":"Post-COVID-19 Chronic Fatigue Syndrome","status":"COMPLETED","sponsor":"ClinAmygate","startDate":"2023-01-08","conditions":"Post-COVID-19 Syndrome, Post-COVID Syndrome","enrollment":528},{"nctId":"NCT05389813","phase":"PHASE2, PHASE3","title":"Comparison Between Oxycodone and Pregabalin as Preemptive Analgesia","status":"UNKNOWN","sponsor":"An-Najah National University","startDate":"2021-08-15","conditions":"Anesthesia","enrollment":150},{"nctId":"NCT03444155","phase":"NA","title":"Natural Versus Synthetic Vitamin B Complexes in Human","status":"COMPLETED","sponsor":"Medical University of Graz","startDate":"2017-05-08","conditions":"Healthy, Thiamine and Niacin Deficiency States, Pyridoxine Deficiency","enrollment":30}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":57,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Synthetic Vitamin B1","genericName":"Synthetic Vitamin B1","companyName":"ClinAmygate","companyId":"clinamygate","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Synthetic Vitamin B1 (thiamine) acts as a coenzyme in carbohydrate metabolism and nervous system function. Used for Thiamine deficiency (beriberi), Wernicke-Korsakoff syndrome, Thiamine supplementation in alcoholism and malnutrition.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}