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Sufentanil and dexmedetomidine
Sufentanil is an opioid agonist that binds mu receptors for analgesia and sedation, while dexmedetomidine is an alpha-2 adrenergic agonist that provides sedation and analgesia through central nervous system effects.
Sufentanil is an opioid agonist that binds mu receptors for analgesia and sedation, while dexmedetomidine is an alpha-2 adrenergic agonist that provides sedation and analgesia through central nervous system effects. Used for Sedation and analgesia in obstetric and gynecological procedures.
At a glance
| Generic name | Sufentanil and dexmedetomidine |
|---|---|
| Sponsor | Obstetrics & Gynecology Hospital of Fudan University |
| Drug class | Opioid agonist and alpha-2 adrenergic agonist combination |
| Target | Mu opioid receptor and alpha-2 adrenergic receptor |
| Modality | Small molecule |
| Therapeutic area | Anesthesia and Analgesia |
| Phase | FDA-approved |
Mechanism of action
This combination pairs sufentanil's potent mu-opioid receptor agonism (providing analgesia and sedation) with dexmedetomidine's selective alpha-2 adrenergic receptor agonism (providing sedation, analgesia, and sympatholytic effects). Together they provide synergistic analgesia and sedation with potentially reduced opioid requirements and improved hemodynamic stability compared to opioids alone.
Approved indications
- Sedation and analgesia in obstetric and gynecological procedures
Common side effects
- Respiratory depression
- Hypotension
- Bradycardia
- Sedation
- Nausea
Key clinical trials
- Cardiac Index and General Anesthesia Without Opioid. (PHASE2, PHASE3)
- Comparison of Anesthetic Techniques for Early Recovery After Ankle Arthroscopy (NA)
- Comparison of C-Reactive Protein Levels in Traumatic Brain Injury Patients Undergoing Craniotomy With and Without Dexmedetomidine (PHASE4)
- Dexmedetomidine and Myocardial Protection (NA)
- Tubeless Spontaneous Ventilation Anesthesia in Kidney Transplantation (NA)
- Impact of Perioperative Dexmedetomidine and Esketamine on Postoperative Quality of Recovery (PHASE4)
- Effect of OFA, OSA Versus Opioid-based Anesthesia on NETs and Cancer Cell Malignancy After Colorectal Cancer Surgery (NA)
- Effectiveness of Dexmedetomidine Versus Sufentanil on Cerebral Oxygen Saturation in Patients With Traumatic Brain Injury (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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