{"id":"sufentanil-and-dexmedetomidine","safety":{"commonSideEffects":[{"rate":null,"effect":"Respiratory depression"},{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Bradycardia"},{"rate":null,"effect":"Sedation"},{"rate":null,"effect":"Nausea"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This combination pairs sufentanil's potent mu-opioid receptor agonism (providing analgesia and sedation) with dexmedetomidine's selective alpha-2 adrenergic receptor agonism (providing sedation, analgesia, and sympatholytic effects). Together they provide synergistic analgesia and sedation with potentially reduced opioid requirements and improved hemodynamic stability compared to opioids alone.","oneSentence":"Sufentanil is an opioid agonist that binds mu receptors for analgesia and sedation, while dexmedetomidine is an alpha-2 adrenergic agonist that provides sedation and analgesia through central nervous system effects.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:10:00.978Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Sedation and analgesia in obstetric and gynecological procedures"}]},"trialDetails":[{"nctId":"NCT05446623","phase":"PHASE2, PHASE3","title":"Cardiac Index and General Anesthesia Without Opioid.","status":"COMPLETED","sponsor":"Centre Hospitalier de Montauban","startDate":"2021-01-01","conditions":"Hip Arthropathy, Hip Disease","enrollment":120},{"nctId":"NCT07460310","phase":"NA","title":"Comparison of Anesthetic Techniques for Early Recovery After Ankle Arthroscopy","status":"NOT_YET_RECRUITING","sponsor":"Second Affiliated Hospital, School of Medicine, Zhejiang University","startDate":"2026-03-01","conditions":"Ankle Sprain, Ankle (Ligaments); Instability (Old Injury), Pain Management","enrollment":200},{"nctId":"NCT07406555","phase":"PHASE4","title":"Comparison of C-Reactive Protein Levels in Traumatic Brain Injury Patients Undergoing Craniotomy With and Without Dexmedetomidine","status":"COMPLETED","sponsor":"Universitas Jenderal Soedirman","startDate":"2025-10-27","conditions":"Traumatic Brain Injury","enrollment":25},{"nctId":"NCT04871308","phase":"NA","title":"Dexmedetomidine and Myocardial Protection","status":"COMPLETED","sponsor":"Seoul National University Hospital","startDate":"2021-07-07","conditions":"Cardiac Surgery, Cardiopulmonary Bypass","enrollment":224},{"nctId":"NCT07377123","phase":"NA","title":"Tubeless Spontaneous Ventilation Anesthesia in Kidney Transplantation","status":"NOT_YET_RECRUITING","sponsor":"Jianxing He","startDate":"2026-01-12","conditions":"Kidney Transplantation, CKD (Chronic Kidney Disease) Stage 5D","enrollment":60},{"nctId":"NCT07308756","phase":"PHASE4","title":"Impact of Perioperative Dexmedetomidine and Esketamine on Postoperative Quality of Recovery","status":"NOT_YET_RECRUITING","sponsor":"Peking University First Hospital","startDate":"2025-12","conditions":"General Anesthesia, Surgery, Dexmedetomidine","enrollment":316},{"nctId":"NCT07264556","phase":"NA","title":"Effect of OFA, OSA Versus Opioid-based Anesthesia on NETs and Cancer Cell Malignancy After Colorectal Cancer Surgery","status":"RECRUITING","sponsor":"Fudan University","startDate":"2025-11-01","conditions":"Colorectal Cancer, Opioid-free Anesthesia, NETs","enrollment":90},{"nctId":"NCT07244822","phase":"NA","title":"Effectiveness of Dexmedetomidine Versus Sufentanil on Cerebral Oxygen Saturation in Patients With Traumatic Brain Injury","status":"COMPLETED","sponsor":"Universitas Jenderal Soedirman","startDate":"2025-06-01","conditions":"Traumatic Brain Injury, Cerebral Oxygen Saturation, NIR Spectroscopy","enrollment":28},{"nctId":"NCT07204106","phase":"NA","title":"Efficacy Study of Dexmedetomidine Nasal Spray Combined With Propofol for Deep Sedation in ERCP","status":"COMPLETED","sponsor":"Shiyou Wei","startDate":"2025-10-02","conditions":"Dexmedetomidine Induced Sedation, Nasal Administration, Sprays","enrollment":180},{"nctId":"NCT06120439","phase":"NA","title":"Comparing the QoR of PECS Block and GA in Breast-conserving Surgery With Sentinel Lymph Node Biopsy","status":"COMPLETED","sponsor":"Jun Zhang","startDate":"2023-12-01","conditions":"Breast Cancer, Pectoral Nerves Block, Breast-Conserving Surgery","enrollment":96},{"nctId":"NCT07045467","phase":"PHASE1","title":"Remimazolam Infusion in Kidney Transplant Patients: A Multicenter Study","status":"RECRUITING","sponsor":"Qianfoshan Hospital","startDate":"2025-07-01","conditions":"Chronic Kidney Diseases, Renal Transplantation","enrollment":30},{"nctId":"NCT06685952","phase":"","title":"The Application of Ultrasonic Measurement of Optic Nerve Sheath Diameter in Liposuction Surgery","status":"COMPLETED","sponsor":"The Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College","startDate":"2024-11-19","conditions":"Optic Nerve Sheath Diameter","enrollment":55},{"nctId":"NCT07179913","phase":"PHASE4","title":"The Improvement of Low-dose Esketamine on Postoperative Depression in Patients Undergoing Bariatric Surgery With Preoperative Depression","status":"NOT_YET_RECRUITING","sponsor":"The First Hospital of Jilin University","startDate":"2025-09-10","conditions":"Depressed, Bariatric Surgery","enrollment":40},{"nctId":"NCT07145775","phase":"PHASE4","title":"Dexmedetomidine-esketamine-ropivacaine Versus Sufentanil-ropivacaine for Epidural Labor Analgesia","status":"NOT_YET_RECRUITING","sponsor":"Peking University First Hospital","startDate":"2025-08","conditions":"Epidural Analgesia, Labor Pain, Sufentanil","enrollment":300},{"nctId":"NCT06530563","phase":"PHASE4","title":"the Efficacy and Safety of Oliceridine Fumarate Injection for Acute Pain After Abdominal Surgery","status":"NOT_YET_RECRUITING","sponsor":"Xiangya Hospital of Central South University","startDate":"2025-08","conditions":"Acute Pain, Opioid Analgesic Adverse Reaction","enrollment":606},{"nctId":"NCT04955249","phase":"PHASE4","title":"Dexmedetomidine Supplemented Analgesia and Delirium After Hip Fracture Surgery","status":"TERMINATED","sponsor":"Peking University First Hospital","startDate":"2021-11-18","conditions":"Elderly, Hip Fracture Surgery, Patient-controlled Analgesia","enrollment":67},{"nctId":"NCT06062550","phase":"PHASE4","title":"Different Dose Esketamine and Dexmedetomidine Combination for Supplemental Analgesia After Scoliosis Correction Surgery","status":"RECRUITING","sponsor":"Peking University First Hospital","startDate":"2023-10-24","conditions":"Scoliosis Correction, Esketamine, Dexmedetomidine","enrollment":312},{"nctId":"NCT06030804","phase":"NA","title":"Perioperative Dexmedetomidine and Long-term Survival After Cancer Surgery","status":"RECRUITING","sponsor":"Peking University First Hospital","startDate":"2023-09-12","conditions":"Elderly, Cancer Surgery, Dexmedetomidine","enrollment":4532},{"nctId":"NCT03629262","phase":"PHASE4","title":"Dexmedetomidine Supplemented Intravenous Analgesia in Elderly After Orthopedic Surgery","status":"COMPLETED","sponsor":"Peking University First Hospital","startDate":"2018-10-28","conditions":"Elderly, Orthopedic Surgery, Analgesia","enrollment":712},{"nctId":"NCT05718544","phase":"PHASE4","title":"Mini-dose Esketamine-dexmedetomidine Supplemented Analgesia and Long-term Outcomes","status":"COMPLETED","sponsor":"Peking University First Hospital","startDate":"2023-01-30","conditions":"Scoliosis Correction, Postoperative Analgesia, Esketamine","enrollment":199},{"nctId":"NCT06087510","phase":"PHASE4","title":"Different Dose Esketamine and Dexmedetomidine for Supplemental Analgesia and Longterm Outcomes","status":"RECRUITING","sponsor":"Peking University First Hospital","startDate":"2024-01-24","conditions":"Scoliosis Correction, Postoperative Analgesia, Esketamine","enrollment":312},{"nctId":"NCT04964219","phase":"PHASE4","title":"Analgesic Effects of Low-dose S-ketamine in Major Spine Fusion Surgery","status":"COMPLETED","sponsor":"Peking University First Hospital","startDate":"2022-02-08","conditions":"S-ketamine, Postoperative Analgesia, Spine Fusion","enrollment":164},{"nctId":"NCT07084753","phase":"NA","title":"Non-opioid Anesthesia Based on Thoracic Paravertebral Block During Laparoscopic Sleeve Gastrectomy","status":"NOT_YET_RECRUITING","sponsor":"IVO JURISIC","startDate":"2025-07-30","conditions":"Obese Patients, Bariatric Surgical Pain, Bariatric Surgery (Sleeve Gastrectomy )","enrollment":36},{"nctId":"NCT06958393","phase":"PHASE4","title":"Effect of Opioid-free Anaesthesia on Postoperative Delirium in Elderly Patients Undergoing Gastrointestinal Surgery","status":"NOT_YET_RECRUITING","sponsor":"Qianfoshan Hospital","startDate":"2025-05-20","conditions":"Delirium - Postoperative, Opioid-Free Anaesthesia","enrollment":406},{"nctId":"NCT06859892","phase":"PHASE4","title":"Dexmedetomidine-Esketamine Combination and Sleep Disturbances After Major Noncardiac Surgery","status":"RECRUITING","sponsor":"Peking University First Hospital","startDate":"2025-03-18","conditions":"Adults, Major Noncardiac Surgery, Dexmedetomidine","enrollment":476},{"nctId":"NCT05411159","phase":"NA","title":"Effect of Opioid-free Anesthesia on PostOperative Nausea and Vomiting in Patients Undergoing Video-assisted Thoracoscopic Surgery","status":"COMPLETED","sponsor":"Beijing Chao Yang Hospital","startDate":"2022-06-07","conditions":"Postoperative Nausea and Vomiting, Opioid Use, Thoracic Diseases","enrollment":168},{"nctId":"NCT06164314","phase":"NA","title":"Perioperative Dexmedetomidine on Postoperative Delirium in Patients With Brain Tumors","status":"RECRUITING","sponsor":"Beijing Tiantan Hospital","startDate":"2024-01-25","conditions":"Postoperative Delirium","enrollment":366},{"nctId":"NCT06712199","phase":"PHASE4","title":"Effect of Oxalidine Combined with Reduced-opioid Anesthesia on Multimodal Analgesia in Morbidly Obese Patients Undergoing Bariatric Surgery","status":"NOT_YET_RECRUITING","sponsor":"Yongtao Sun","startDate":"2025-01-01","conditions":"Morbid Obesity","enrollment":124},{"nctId":"NCT05249153","phase":"NA","title":"Dexmedetomidine and Sufentanil Effect in PCA on Pediatric Patients Undergoing Scoliosis Surgery","status":"UNKNOWN","sponsor":"Peking Union Medical College Hospital","startDate":"2020-09-23","conditions":"Dexmedetomidine","enrollment":84},{"nctId":"NCT06662656","phase":"","title":"ED50 of Sufentanil for Intraoperative Analgesia","status":"NOT_YET_RECRUITING","sponsor":"China International Neuroscience Institution","startDate":"2024-11-01","conditions":"Laparoscopic Cholecystectomy, Analgesics，Opioid","enrollment":26},{"nctId":"NCT06566482","phase":"PHASE4","title":"Mini-dose Dexmedetomidine-Esketamine Supplemented Analgesia in Patients at High-risk of OSA","status":"RECRUITING","sponsor":"Peking University First Hospital","startDate":"2024-09-11","conditions":"Obstructive Sleep Apnea, Surgery, Dexmedetomidine","enrollment":100},{"nctId":"NCT06493396","phase":"NA","title":"Effect of Opioid-free Anesthesia on Sleep Quality, Cognitive Function and Recovery Quality After General Anesthesia in Elderly Patients","status":"NOT_YET_RECRUITING","sponsor":"Beijing Friendship Hospital","startDate":"2024-08-01","conditions":"Opioid-Free Anesthesia, POCD, Recovery Quality","enrollment":88},{"nctId":"NCT06382961","phase":"NA","title":"Postoperative Dexmedetomidine in Prevention of Postoperative Delirium","status":"COMPLETED","sponsor":"Boston Intelligent Medical Research Center, Shenzhen United Scheme Technology Co., Ltd.","startDate":"2023-11-11","conditions":"Delirium in Old Age, Anesthesia; Adverse Effect","enrollment":287},{"nctId":"NCT06305221","phase":"NA","title":"Effect of Opioid-free Analgesia and Anesthesia on the Quality of Postoperative Recovery and Nausea Vomit in Patients Receiving Laparoscopic Sleeve Gastrectomy","status":"RECRUITING","sponsor":"Beijing Friendship Hospital","startDate":"2024-03-09","conditions":"Opioid-Free Anesthesia, Laparoscopic Sleeve Gastrectomy, Postoperative Vomiting","enrollment":76},{"nctId":"NCT05888389","phase":"NA","title":"Nerve Block Anesthesia Combined With Sedative Anesthesia Versus General Anesthesia in Surgery for CSDH","status":"RECRUITING","sponsor":"Beijing Tiantan Hospital","startDate":"2024-04-01","conditions":"Chronic Subdural Hematoma, Anesthesia","enrollment":190},{"nctId":"NCT05314569","phase":"PHASE1","title":"Cardioprotective Effect of Ketamine-dexmeditomidine Versus Fentanyl-midazolam in Open Heart Surgery in Pediatrics","status":"COMPLETED","sponsor":"Cairo University","startDate":"2022-04-15","conditions":"Anesthesia","enrollment":81},{"nctId":"NCT06199011","phase":"NA","title":"Effect of Esketamine on Depressive Symptoms of Obese Patients Undergoing Laparoscopic Sleeve Gastrectomy","status":"UNKNOWN","sponsor":"The Second Hospital of Anhui Medical University","startDate":"2024-01-01","conditions":"Depressive Symptoms","enrollment":400},{"nctId":"NCT04144933","phase":"PHASE3","title":"Effect of Multimodal Opioid-free Anesthesia on Return of Bowel Function in Laparoscopic Colorectal Surgery","status":"UNKNOWN","sponsor":"University of Saskatchewan","startDate":"2021-05-15","conditions":"Anesthesia, General Anesthesia, Analgesics, Opioid","enrollment":60},{"nctId":"NCT05308355","phase":"","title":"Opioid-free Anesthesia and Thoracoscopy Surgery","status":"COMPLETED","sponsor":"Nantes University Hospital","startDate":"2022-04-04","conditions":"Opioid Free Anesthesia, Thoracic Surgery","enrollment":90},{"nctId":"NCT03770130","phase":"EARLY_PHASE1","title":"Dexmedetomidine and Liver Transplantation","status":"COMPLETED","sponsor":"RenJi Hospital","startDate":"2019-01-14","conditions":"Dexmedetomidine, Liver Transplantation, Allograft Function, Survival","enrollment":330},{"nctId":"NCT02923128","phase":"PHASE4","title":"Whether Dexmedetomidine Can Improve the Prognosis of Elderly Patients With Postoperative Cognitive Dysfunction","status":"COMPLETED","sponsor":"Zhejiang Cancer Hospital","startDate":"2016-11","conditions":"Postoperative Cognitive Dysfunction, Postoperative Delirium","enrollment":240},{"nctId":"NCT05445024","phase":"NA","title":"Combination of Nalbuphine and Dexmedetomidine Versus Sufentanil and Dexmedetomidine on Patients","status":"UNKNOWN","sponsor":"Qianfoshan Hospital","startDate":"2023-01-01","conditions":"Laparoscopic, Gastrointestinal Surgery","enrollment":300},{"nctId":"NCT05072704","phase":"PHASE3","title":"Opioid Free Anesthesia in Total Hip Arthroplasty","status":"COMPLETED","sponsor":"CMC Ambroise Paré","startDate":"2022-02-03","conditions":"Primary Total Hip Arthroplasty","enrollment":80},{"nctId":"NCT05691088","phase":"NA","title":"Clinical Efficacy of Acetaminophen in Mechanical Ventilation in Children With New Coronary Pneumonia","status":"UNKNOWN","sponsor":"The Second Clinical Medical College of Jinan University","startDate":"2022-12-15","conditions":"Acetaminophen,Mechanical Ventilation,Critically Ill Children","enrollment":128},{"nctId":"NCT04791059","phase":"PHASE4","title":"Low-dose S-ketamine and Dexmedetomidine in Combination With Opioids for Postoperative Analgesia","status":"COMPLETED","sponsor":"Peking University First Hospital","startDate":"2021-04-09","conditions":"Scoliosis Correction, Postoperative Analgesia, S-ketamine","enrollment":200},{"nctId":"NCT04877639","phase":"PHASE4","title":"Safety and Efficacy of Esmketamine Versus Dexmedetomidine","status":"UNKNOWN","sponsor":"Zhongnan Hospital","startDate":"2021-05-01","conditions":"Osa Syndrome","enrollment":80},{"nctId":"NCT05386979","phase":"NA","title":"Multimodal Analgesic Management of Naborphine Combined With Opioid Free Anesthesia in OSA Patients Undergoing Bariatric Surgery","status":"UNKNOWN","sponsor":"Qianfoshan Hospital","startDate":"2022-05-15","conditions":"Analgesics，Opioid, Bariatric Surgery","enrollment":48},{"nctId":"NCT05011617","phase":"NA","title":"Monitored Anesthesia Care Versus Intubated General Anesthesia for Open Heart Surgery Under Cardiopulmonary Bypass","status":"COMPLETED","sponsor":"ShuGuang Hospital","startDate":"2012-04-01","conditions":"Monitored Anesthesia Care, Cardiac Surgery, Postoperative Recovery","enrollment":30},{"nctId":"NCT04642651","phase":"PHASE4","title":"Dexmedetomidine as an Adjuvant for Femoral Nerve Block and Functional Recovery After Total Knee Arthroplasty","status":"COMPLETED","sponsor":"Peking University First Hospital","startDate":"2020-11-25","conditions":"Elderly, Total Knee Arthroplasty, Femoral Nerve Block","enrollment":170},{"nctId":"NCT04767256","phase":"NA","title":"Intravenous Dexamethasone and Dexmedetomidine on the Analgesic Efficacy of Erector Spinae Plane Block","status":"COMPLETED","sponsor":"Huazhong University of Science and Technology","startDate":"2021-03-01","conditions":"Dexamethasone, Dexmedetomidine, Nerve Block","enrollment":120},{"nctId":"NCT04306159","phase":"NA","title":"Application of Rectus Sheath Block based-on Incision in Upper Abdominal Surgery","status":"COMPLETED","sponsor":"The First Affiliated Hospital of Anhui Medical University","startDate":"2020-03-15","conditions":"Opioid Consumption","enrollment":126},{"nctId":"NCT03096730","phase":"NA","title":"Effect of Dexmedetomidine Combined With Low-dose Nalmefene on Preventing Remifentanil-induced Postoperative Hyperalgesia","status":"COMPLETED","sponsor":"Tianjin Medical University General Hospital","startDate":"2017-02-06","conditions":"Pain, Anesthesia","enrollment":150},{"nctId":"NCT02741219","phase":"PHASE4","title":"A Multicenter Study: Dexmedetomidine Combined With Sufentanil for Patient Controlled Intravenous Analgesia After Caesarean Section","status":"COMPLETED","sponsor":"Obstetrics & Gynecology Hospital of Fudan University","startDate":"2015-11","conditions":"Postoperative Pain","enrollment":225},{"nctId":"NCT04854577","phase":"NA","title":"Postoperative Opioid-Sparing Effect of a Pecto-Intercostal Fascial Block and Opioid-Free Anesthesia.","status":"UNKNOWN","sponsor":"Algemeen Stedelijk Ziekenhuis","startDate":"2021-05","conditions":"Opioid Free Anaesthesia, Opioid Anaesthesia","enrollment":64},{"nctId":"NCT04788732","phase":"","title":"Heart Rate Variability to Quantify General Anesthesia Depth","status":"UNKNOWN","sponsor":"University of Sao Paulo","startDate":"2021-01-04","conditions":"Anesthesia Awareness","enrollment":200},{"nctId":"NCT03202134","phase":"","title":"Impact of Opioid Free Anesthesia on Outcome After DIEPflap Surgery","status":"COMPLETED","sponsor":"AZ Sint-Jan AV","startDate":"2014-01","conditions":"Major and Minor Surgical Complications","enrollment":204},{"nctId":"NCT04111328","phase":"PHASE4","title":"the Effect of Different Drugs and Infusion Ways on Degree of Postoperative Comfort","status":"COMPLETED","sponsor":"Jun Wang","startDate":"2019-10-08","conditions":"Analgesia, Patient-Controlled","enrollment":600},{"nctId":"NCT04507165","phase":"NA","title":"Opioid-free Anesthesia in VATS Lung Resection","status":"UNKNOWN","sponsor":"Peking University People's Hospital","startDate":"2020-08","conditions":"Opioid Free Anesthesia","enrollment":100},{"nctId":"NCT03086213","phase":"NA","title":"Comparative Study of Nonintubated Uniport Thoracoscopic Surgery Using Thoracic Paravertebral Nerve Block Versus Intercostal Nerve Block for Peripheral Solitary Pulmonary Nodule Patients","status":"COMPLETED","sponsor":"Shenzhen Third People's Hospital","startDate":"2017-03-01","conditions":"Peripheral Solitary Pulmonary Nodule or Tuberculoma","enrollment":48},{"nctId":"NCT02752477","phase":"PHASE3","title":"Efficacy of Opioid-free Anesthesia in Reducing Postoperative Pain in Chronic Pain Patients Undergoing Spinal Surgery","status":"UNKNOWN","sponsor":"Ben Lim","startDate":"2016-08-02","conditions":"Chronic Pain, Anesthesia","enrollment":30},{"nctId":"NCT03787550","phase":"","title":"PK/PD of the Sedatives, Analgesics and Antibiotics in Patients Receiving ECMO","status":"UNKNOWN","sponsor":"Guangdong Provincial People's Hospital","startDate":"2020-02-07","conditions":"Drug Effect","enrollment":36},{"nctId":"NCT03622047","phase":"NA","title":"Comparison of Epidural Labor Analgesia With Dexmedetomidine or Sufentanil","status":"UNKNOWN","sponsor":"Fudan University","startDate":"2018-08-15","conditions":"Pharmacological Action","enrollment":1800},{"nctId":"NCT03660306","phase":"","title":"Impact of OFA During LPV on Postoperative Oxygen Saturation","status":"COMPLETED","sponsor":"AZ Sint-Jan AV","startDate":"2018-08-01","conditions":"Decreased Lung Compliance, Oxygen Requirement","enrollment":64},{"nctId":"NCT03805945","phase":"PHASE4","title":"Effect of Dexmedetomidine on Parturient Undergoing Elective Cesarean Section.","status":"COMPLETED","sponsor":"The Affiliated Hospital of Xuzhou Medical University","startDate":"2019-06-01","conditions":"Cesarean Section","enrollment":160},{"nctId":"NCT03763084","phase":"EARLY_PHASE1","title":"Impact of Acetaminophen on Postoperative Delirium Elderly Patients After Non-cardiac Surgery","status":"UNKNOWN","sponsor":"Xiangya Hospital of Central South University","startDate":"2019-02-15","conditions":"Acetaminophen, Delirium in Old Age","enrollment":164},{"nctId":"NCT03124680","phase":"NA","title":"Opioid Free Anesthesia and Continuous Post-operative Pulse Oximetry Monitoring in the Obese Patient","status":"COMPLETED","sponsor":"Université Libre de Bruxelles","startDate":"2017-04-20","conditions":"Anesthesia","enrollment":30},{"nctId":"NCT02479581","phase":"PHASE2","title":"The Safety and Efficacy of the Enhanced Recovery After Surgery(ERAS)Applied on Cardiac Surgery With Cardiopulmonary Bypass","status":"COMPLETED","sponsor":"Xiangya Hospital of Central South University","startDate":"2015-07","conditions":"Valvular Heart Disease","enrollment":226},{"nctId":"NCT03137628","phase":"","title":"Effect of General Anesthesia and Mechanical Ventilation on Plasma Metabolite in Patient With Colorectal Cancer Resection","status":"UNKNOWN","sponsor":"Xinhua Hospital, Shanghai Jiao Tong University School of Medicine","startDate":"2017-03-20","conditions":"Metabolomics","enrollment":80},{"nctId":"NCT03135795","phase":"PHASE4","title":"The Epigenetic Modification in OPRM1 on Postoperative Analgesia and Side Effect Induced by Sufentanil","status":"UNKNOWN","sponsor":"Huazhong University of Science and Technology","startDate":"2017-02-06","conditions":"Epigenetics","enrollment":100},{"nctId":"NCT03117023","phase":"PHASE3","title":"The Addition of Dexmedetomidine on Postoperative Sleep for Middle-aged and Elderly Patients With Gastric Cancer","status":"UNKNOWN","sponsor":"Nanjing PLA General Hospital","startDate":"2017-04-15","conditions":"Gastric Cancer","enrollment":50},{"nctId":"NCT02727712","phase":"PHASE4","title":"Studies of Application of Combined General Anesthesia and Bilateral TPVB in OPCABG","status":"UNKNOWN","sponsor":"Xiangya Hospital of Central South University","startDate":"2016-04","conditions":"Coronary Heart Disease","enrollment":60},{"nctId":"NCT02134093","phase":"PHASE4","title":"Effects of Dexmedetomidine on Postoperative Cognitive Dysfunction During One-lung Ventilation in Elder Patients","status":"UNKNOWN","sponsor":"Tang-Du Hospital","startDate":"2014-07","conditions":"Postoperative Confusion","enrollment":120},{"nctId":"NCT02169843","phase":"PHASE4","title":"Small Doses of Dexmedetomidine for Emergence Agitation","status":"UNKNOWN","sponsor":"Tang-Du Hospital","startDate":"2014-05","conditions":"Emergence Agitation","enrollment":80},{"nctId":"NCT02154074","phase":"PHASE4","title":"Dexmedetomidine Influence on the Level of Perioperative Blood Glucose and Insulin of Elderly Diabetes Patients","status":"UNKNOWN","sponsor":"Second Affiliated Hospital of Xi'an Jiaotong University","startDate":"2014-05","conditions":"Perioperative Blood Glucose and Insulin","enrollment":92},{"nctId":"NCT02123355","phase":"PHASE4","title":"The Effect of Dexmedetomidine to Cognition of Geriatrics in Prolonged Surgery","status":"UNKNOWN","sponsor":"Shaanxi Provincial People's Hospital","startDate":"2014-08","conditions":"Cognitive Ability, General, Brain Injury","enrollment":80},{"nctId":"NCT01517932","phase":"PHASE4","title":"Effects of Dexmedetomidine on Stress Response and Postoperative Analgesia","status":"COMPLETED","sponsor":"Fang Luo","startDate":"2011-06","conditions":"Restlessness, Pain","enrollment":60},{"nctId":"NCT01785446","phase":"NA","title":"Study of Cisatracurium and Sufentanil Consumption Using a Closed Loop Computer Control Infusion System","status":"UNKNOWN","sponsor":"Tianjin Medical University General Hospital","startDate":"2012-11","conditions":"The Intraoperative Effect of Dexmedetomidine on Cisatracurium Infusion Consumption and Its Recovery Index., Effect of Dexmedetomidine on Sufentanil Consumption., Quantitative Analysis of Cisatracurium Infusion Requirements, Sufentanil Consumption and Recovery Index in Different Age Groups.","enrollment":150},{"nctId":"NCT00848991","phase":"PHASE3","title":"Comparison of Propofol to Precedex With Propofol for Emergence and Recovery in Patients Having Craniotomy Surgery","status":"COMPLETED","sponsor":"The Cooper Health System","startDate":"2009-02","conditions":"Cranitomy Surgery","enrollment":15}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Sufentanil and dexmedetomidine","genericName":"Sufentanil and dexmedetomidine","companyName":"Obstetrics & Gynecology Hospital of Fudan University","companyId":"obstetrics-gynecology-hospital-of-fudan-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Sufentanil is an opioid agonist that binds mu receptors for analgesia and sedation, while dexmedetomidine is an alpha-2 adrenergic agonist that provides sedation and analgesia through central nervous system effects. Used for Sedation and analgesia in obstetric and gynecological procedures.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}