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sodium thiosulfate solution
sodium thiosulfate solution is a Antidote Small molecule drug developed by Xijing Hospital of Digestive Diseases. It is currently in Phase 3 development for Cyanide poisoning. Also known as: STS.
Sodium thiosulfate solution works by neutralizing cyanide ions.
Sodium thiosulfate solution is a small molecule intervention used in various clinical trials, including those for Endodontic Disease, Endodontic Inflammation, Renal Transplant, Kidney Transplant, and Gastrointestinal Neoplasms. The exact mechanism of action of sodium thiosulfate solution is currently unknown.
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Baseline phase 3 → approval rate
+58.3pp
Industry-wide phase 3 drugs reach approval ~58.3% of the time (BIO/Informa 2023 industry benchmark across all therapeutic areas).
| Regulator | Country | Likely year | Lag vs FDA |
|---|---|---|---|
| FDA | US | 2028–2030 | — |
| EMA | EU | 2029–2031 | +0.7 yr |
| MHRA | GB | 2029–2031 | +0.7 yr |
| Health Canada | CA | 2029–2032 | +0.9 yr |
| TGA | AU | 2029–2032 | +1.2 yr |
| PMDA | JP | 2029–2032 | +1.5 yr |
| NMPA | CN | 2030–2033 | +2.3 yr |
| MFDS | KR | 2029–2032 | +1.4 yr |
| CDSCO | IN | 2029–2033 | +1.8 yr |
| ANVISA | BR | 2030–2033 | +2.3 yr |
Hover any row for the lag rationale. Lag estimates are reduced when the drug has FDA Breakthrough or EMA PRIME designation (sponsors file globally in parallel).
Estimate based on the BIO/Informa industry phase transition rates plus per-drug modifiers for therapeutic area, sponsor type, FDA designations, mechanism, and trial design. Per-jurisdiction lags from Tufts CSDD international approval studies. Not investment, clinical or regulatory advice. Methodology: /methodology#likelihood.
At a glance
| Generic name | sodium thiosulfate solution |
|---|---|
| Also known as | STS |
| Sponsor | Xijing Hospital of Digestive Diseases |
| Drug class | Antidote |
| Modality | Small molecule |
| Therapeutic area | Toxicology |
| Phase | Phase 3 |
Mechanism of action
It does this by forming a stable complex with cyanide, which is then excreted from the body. This mechanism is particularly useful in treating cyanide poisoning.
Approved indications
- Cyanide poisoning
Common side effects
- Hypocalcemia
- Hypophosphatemia
- Nausea
- Vomiting
- Diarrhea
Key clinical trials
- Individual Response to Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Treatment of Peritoneal Carcinomatosis From Peritoneal Mesothelioma or Atypical Mesothelial Proliferation or From Ovarian, Colorectal, or Appendiceal Histologies (PHASE1)
- Comparing the Effect of Different Intracanal Dressing on Failed Root Canal Treated Cases on Periapical Healing (PHASE2)
- Better Evidence and Translation for Calciphylaxis (PHASE3)
- Antibacterial Efficacy and Outcomes of Root Canal Irrigation Methods (NA)
- The Effect of Sodium Thiosulfate Eardrops on Hearing Loss in Patients Who Receive Cisplatin Therapy (NA)
- Evaluation of Thiosulfate Enhanced Organ Preservation Solution in Kidney Transplantation (NA)
- Evaluation of Thiosulfate in End Stage Renal Disease and Kidney Transplantation (PHASE1)
- Study to Evaluate Safety and Efficacy of DB-020 to Protect Hearing in Patients Receiving Cisplatin for Cancer Treatment (PHASE1)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- sodium thiosulfate solution CI brief — competitive landscape report
- sodium thiosulfate solution updates RSS · CI watch RSS
- Xijing Hospital of Digestive Diseases portfolio CI
Frequently asked questions about sodium thiosulfate solution
What is sodium thiosulfate solution?
How does sodium thiosulfate solution work?
What is sodium thiosulfate solution used for?
Who makes sodium thiosulfate solution?
Is sodium thiosulfate solution also known as anything else?
What drug class is sodium thiosulfate solution in?
What development phase is sodium thiosulfate solution in?
What are the side effects of sodium thiosulfate solution?
Related
- Drug class: All Antidote drugs
- Manufacturer: Xijing Hospital of Digestive Diseases — full pipeline
- Therapeutic area: All drugs in Toxicology
- Indication: Drugs for Cyanide poisoning
- Also known as: STS
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing