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Strontium Ranelate + Ca/Vitamin-D
Strontium ranelate promotes bone formation and reduces bone resorption, while calcium and vitamin D provide essential minerals and cofactors for bone mineralization and calcium homeostasis.
Strontium ranelate promotes bone formation and reduces bone resorption, while calcium and vitamin D provide essential minerals and cofactors for bone mineralization and calcium homeostasis. Used for Osteoporosis in postmenopausal women, Osteoporosis in men at high risk of fracture.
At a glance
| Generic name | Strontium Ranelate + Ca/Vitamin-D |
|---|---|
| Also known as | Protelos (r) |
| Sponsor | Medical University of Vienna |
| Drug class | Bone-active agent / Antiosteoporotic combination |
| Target | Osteoblasts and osteoclasts (non-receptor mediated); calcium-sensing receptor (vitamin D component) |
| Modality | Small molecule |
| Therapeutic area | Orthopedics / Rheumatology |
| Phase | FDA-approved |
Mechanism of action
Strontium ranelate acts as a dual-action agent that stimulates osteoblast differentiation and bone formation while simultaneously inhibiting osteoclast-mediated bone resorption. The addition of calcium and vitamin D enhances intestinal calcium absorption and provides the mineral substrate necessary for effective bone mineralization, creating a comprehensive approach to improving bone density and strength.
Approved indications
- Osteoporosis in postmenopausal women
- Osteoporosis in men at high risk of fracture
Common side effects
- Nausea
- Diarrhea
- Headache
- Venous thromboembolism
- Dermatitis
Key clinical trials
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Strontium Ranelate + Ca/Vitamin-D CI brief — competitive landscape report
- Strontium Ranelate + Ca/Vitamin-D updates RSS · CI watch RSS
- Medical University of Vienna portfolio CI