{"id":"strontium-ranelate-ca-vitamin-d","safety":{"commonSideEffects":[{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Diarrhea"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Venous thromboembolism"},{"rate":null,"effect":"Dermatitis"}]},"_chembl":{"chemblId":"CHEMBL3707306","moleculeType":"Small molecule","molecularWeight":"513.49"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Strontium ranelate acts as a dual-action agent that stimulates osteoblast differentiation and bone formation while simultaneously inhibiting osteoclast-mediated bone resorption. The addition of calcium and vitamin D enhances intestinal calcium absorption and provides the mineral substrate necessary for effective bone mineralization, creating a comprehensive approach to improving bone density and strength.","oneSentence":"Strontium ranelate promotes bone formation and reduces bone resorption, while calcium and vitamin D provide essential minerals and cofactors for bone mineralization and calcium homeostasis.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:09:46.281Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Osteoporosis in postmenopausal women"},{"name":"Osteoporosis in men at high risk of fracture"}]},"trialDetails":[{"nctId":"NCT01222026","phase":"PHASE4","title":"Systematic Treatment After Successful Surgical Treatment for Primary Hyperparathyroidism With Strontium Ranelate","status":"COMPLETED","sponsor":"Medical University of Vienna","startDate":"2010-09","conditions":"Primary Hyperparathyroidism, Osteopenia, Osteoporosis","enrollment":63}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Protelos (r)"],"phase":"marketed","status":"active","brandName":"Strontium Ranelate + Ca/Vitamin-D","genericName":"Strontium Ranelate + Ca/Vitamin-D","companyName":"Medical University of Vienna","companyId":"medical-university-of-vienna","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Strontium ranelate promotes bone formation and reduces bone resorption, while calcium and vitamin D provide essential minerals and cofactors for bone mineralization and calcium homeostasis. Used for Osteoporosis in postmenopausal women, Osteoporosis in men at high risk of fracture.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}