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Stepwise add-on therapy
Stepwise add-on therapy is a treatment strategy that sequentially adds medications to achieve therapeutic goals rather than using a single high-dose agent.
At a glance
| Generic name | Stepwise add-on therapy |
|---|---|
| Also known as | Metformin, Glimepiride, Sitagliptin |
| Sponsor | Korea University Anam Hospital |
| Modality | Small molecule |
| Phase | Phase 3 |
Mechanism of action
This approach involves initiating treatment with a single agent at a standard dose, then progressively adding complementary medications based on clinical response and tolerability. The stepwise strategy aims to optimize efficacy while minimizing adverse effects by titrating therapy incrementally rather than starting with combination regimens.
Approved indications
Common side effects
Key clinical trials
- PENG Block & PENG PRF
- GLP-1/GCG Dual Agonist in Type 2 Diabetes With Early Dementia (LIGHT-COG Study) (PHASE3)
- Standardized Sleep Bundle for Cardiac Surgery Patients (NA)
- Proactive TDM Versus Standard Use of Biologics in Psoriasis (PHASE4)
- Study of Biomarker-Based Treatment of Acute Myeloid Leukemia (PHASE1, PHASE2)
- Comparing ACT, Recuperation, and ACT Plus Vocational Support for Clinical Burnout (NA)
- PCSK9 inhibitoRs for Early Passivation of coRonary athEroSclerotic plaqueS in Acute Coronary Syndromes (REPRESS) (NA)
- Evaluation of Risk-Adapted and MRD-Driven Strategy for Untreated Fit Patients With Intermediate Risk Chronic Lymphocytic Leukemia (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Stepwise add-on therapy CI brief — competitive landscape report
- Stepwise add-on therapy updates RSS · CI watch RSS
- Korea University Anam Hospital portfolio CI