{"id":"stepwise-add-on-therapy","safety":{"commonSideEffects":[]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This approach involves initiating treatment with a single agent at a standard dose, then progressively adding complementary medications based on clinical response and tolerability. The stepwise strategy aims to optimize efficacy while minimizing adverse effects by titrating therapy incrementally rather than starting with combination regimens.","oneSentence":"Stepwise add-on therapy is a treatment strategy that sequentially adds medications to achieve therapeutic goals rather than using a single high-dose agent.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T00:53:34.165Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[]},"trialDetails":[{"nctId":"NCT07360093","phase":"","title":"PENG Block & PENG PRF","status":"RECRUITING","sponsor":"Ankara City Hospital Bilkent","startDate":"2026-02-01","conditions":"Osteoarthritis (OA) of the Hip","enrollment":84},{"nctId":"NCT07083154","phase":"PHASE3","title":"GLP-1/GCG Dual Agonist in Type 2 Diabetes With Early Dementia (LIGHT-COG Study)","status":"RECRUITING","sponsor":"The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School","startDate":"2025-09-27","conditions":"Dementia, Mild, Mild Cognitive Impairment, Type 2 Diabetes","enrollment":420},{"nctId":"NCT07401836","phase":"NA","title":"Standardized Sleep Bundle for Cardiac Surgery Patients","status":"NOT_YET_RECRUITING","sponsor":"Horizon Health Network","startDate":"2026-03","conditions":"Sleep","enrollment":20},{"nctId":"NCT06398106","phase":"PHASE4","title":"Proactive TDM Versus Standard Use of Biologics in Psoriasis","status":"RECRUITING","sponsor":"University Hospital, Ghent","startDate":"2024-12-20","conditions":"Psoriasis Vulgaris","enrollment":210},{"nctId":"NCT03013998","phase":"PHASE1, PHASE2","title":"Study of Biomarker-Based Treatment of Acute Myeloid Leukemia","status":"RECRUITING","sponsor":"Beat AML, LLC","startDate":"2016-11","conditions":"Previously Untreated Relapsed Refractory Acute Myeloid Leukemia","enrollment":3000},{"nctId":"NCT07272421","phase":"NA","title":"Comparing ACT, Recuperation, and ACT Plus Vocational Support for Clinical Burnout","status":"NOT_YET_RECRUITING","sponsor":"Uppsala University","startDate":"2025-12-01","conditions":"Burnout, Clinical Burnout, Exhaustion Disorder","enrollment":210},{"nctId":"NCT06791031","phase":"NA","title":"PCSK9 inhibitoRs for Early Passivation of coRonary athEroSclerotic plaqueS in Acute Coronary Syndromes (REPRESS)","status":"NOT_YET_RECRUITING","sponsor":"West China Hospital","startDate":"2026-01","conditions":"Coronary Artery Disease","enrollment":212},{"nctId":"NCT04010968","phase":"PHASE2","title":"Evaluation of Risk-Adapted and MRD-Driven Strategy for Untreated Fit Patients With Intermediate Risk Chronic Lymphocytic Leukemia","status":"COMPLETED","sponsor":"French Innovative Leukemia Organisation","startDate":"2019-09-27","conditions":"Intermediate Risk Chronic Lymphocytic Leukemia, Fit Patients, Risk-Adapted and MRD-Driven Strategy","enrollment":120},{"nctId":"NCT07027969","phase":"PHASE4","title":"Metabolic Surgery for Atrial Fibrillation Elimination","status":"NOT_YET_RECRUITING","sponsor":"Ali Aminian","startDate":"2026-02-01","conditions":"Atrial Fibrillation, Obesity and Obesity-related Medical Conditions","enrollment":100},{"nctId":"NCT07169162","phase":"PHASE4","title":"ADZENYS XR-ODT™ in Children (4 to <6 Years) Diagnosed With Attention-deficit/Hyperactivity Disorder","status":"WITHDRAWN","sponsor":"Aytu BioPharma, Inc.","startDate":"2019-05","conditions":"Attention Deficit Hyperactivity Disorder","enrollment":""},{"nctId":"NCT06212687","phase":"NA","title":"Evaluation of a Digital Pre-therapy Patient Education Program (StartHjelp) in Outpatient Mental Health Care","status":"RECRUITING","sponsor":"St. Olavs Hospital","startDate":"2024-12-15","conditions":"Mental Health Issue, Mental Disorder, Patient Education","enrollment":170},{"nctId":"NCT06288594","phase":"NA","title":"TraumaRelief App: A Pilot RCT Assessing Feasibility and Acceptability","status":"COMPLETED","sponsor":"Dokuz Eylul University","startDate":"2024-12-01","conditions":"Post-Traumatic Stress Disorder (PTSD)","enrollment":107},{"nctId":"NCT05014503","phase":"NA","title":"A Computerized, Adaptive Therapeutic Gaming Approach Training Visual Perceptual Skills in Children With CVI","status":"COMPLETED","sponsor":"Universitaire Ziekenhuizen KU Leuven","startDate":"2022-01-02","conditions":"Cerebral Visual Impairment","enrollment":73},{"nctId":"NCT06700252","phase":"NA","title":"Effects of Vestibular Rehabilitation in the Treatment of Dizziness and Balance Disturbances After Concussion","status":"COMPLETED","sponsor":"Beth Marschner","startDate":"2022-08-25","conditions":"Concussion","enrollment":10},{"nctId":"NCT03503942","phase":"NA","title":"The Pre-Diabetes Interventions and Continued Tracking to Ease-out Diabetes (Pre-DICTED) Program","status":"COMPLETED","sponsor":"Singapore General Hospital","startDate":"2017-12-30","conditions":"Pre-diabetes","enrollment":751},{"nctId":"NCT05962437","phase":"NA","title":"Self-guided Acceptance and Commitment Therapy-based Digital Smartphone Application for Management of Fibromyalgia","status":"UNKNOWN","sponsor":"Fundació Sant Joan de Déu","startDate":"2024-01-01","conditions":"Fibromyalgia","enrollment":360},{"nctId":"NCT01221480","phase":"","title":"What Influences Patient Outcome in Obstructive Airway Disease?","status":"COMPLETED","sponsor":"University of Dundee","startDate":"2010-08","conditions":"COPD","enrollment":5977},{"nctId":"NCT04907123","phase":"PHASE3","title":"Systematic Escalation of diuREtics With Natriuresis in Heart Failure Patients: SERENA Trial","status":"UNKNOWN","sponsor":"University of Turin, Italy","startDate":"2021-10","conditions":"Heart Failure","enrollment":198},{"nctId":"NCT02210728","phase":"NA","title":"Efficacy of Cognitive Behavioral Therapy in Treatment of Adults With Attention Deficit Hyperactivity Disorder","status":"UNKNOWN","sponsor":"Lily Hechtman","startDate":"2006-04","conditions":"Attention Deficit Hyperactivity Disorder","enrollment":200},{"nctId":"NCT02788851","phase":"NA","title":"The Effectiveness of Aerobic Exercise in the Treatment of Adults With Attention Deficit Hyperactivity Disorder (ADHD)","status":"UNKNOWN","sponsor":"McGill University Health Centre/Research Institute of the McGill University Health Centre","startDate":"2016-04","conditions":"Attention Deficit Hyperactivity Disorder (ADHD)","enrollment":70},{"nctId":"NCT02566824","phase":"PHASE4","title":"Cognitive Behavioral Therapy for Adolescents With Attention-Deficit / Hyperactivity Disorder","status":"UNKNOWN","sponsor":"McGill University Health Centre/Research Institute of the McGill University Health Centre","startDate":"2010-10","conditions":"Attention Deficit Hyperactivity Disorder","enrollment":216},{"nctId":"NCT01535768","phase":"PHASE4","title":"Effect of Prophylactic Aqueous Suppression on Hyperencapsulation of Ahmed Glaucoma Valves","status":"UNKNOWN","sponsor":"Credit Valley EyeCare","startDate":"2012-02","conditions":"Glaucoma","enrollment":150},{"nctId":"NCT00537303","phase":"PHASE4","title":"Comparison of the Blood Sugar Lowering Effect and Safety of Two Insulin Treatments in Type 2 Diabetes","status":"COMPLETED","sponsor":"Novo Nordisk A/S","startDate":"2007-10","conditions":"Diabetes, Diabetes Mellitus, Type 2","enrollment":296},{"nctId":"NCT01165684","phase":"PHASE4","title":"Efficacy and Safety of Basal-bolus Therapy, Comparing Stepwise Addition of Insulin Aspart Versus Complete Basal-bolus Regimen","status":"COMPLETED","sponsor":"Novo Nordisk A/S","startDate":"2010-10","conditions":"Diabetes, Diabetes Mellitus, Type 2","enrollment":401},{"nctId":"NCT01068652","phase":"PHASE4","title":"Effect of Different Insulin Administrations, All in Combination With Metformin, on Glycaemic Control in Subjects With Type 2 Diabetes Inadequately Controlled by Oral Anti-diabetic Drugs","status":"COMPLETED","sponsor":"Novo Nordisk A/S","startDate":"2010-03","conditions":"Diabetes, Diabetes Mellitus, Type 2","enrollment":403},{"nctId":"NCT02208219","phase":"NA","title":"Music Therapy to Restore Motor Deficits After Stroke","status":"UNKNOWN","sponsor":"University of Barcelona","startDate":"2013-11","conditions":"Stroke, Paresis","enrollment":120},{"nctId":"NCT02946632","phase":"PHASE3","title":"Effectiveness & Tolerability of Novel, Initial Triple Combination Therapy vs Conventional Therapy in Type 2 Diabetes","status":"UNKNOWN","sponsor":"Korea University Anam Hospital","startDate":"2016-12","conditions":"Diabetes Mellitus, Type II","enrollment":104},{"nctId":"NCT02684305","phase":"PHASE3","title":"Stepwise Labor Induction Following Failure of Prostaglandin Vaginal Insert for Labor Induction","status":"UNKNOWN","sponsor":"Tel-Aviv Sourasky Medical Center","startDate":"2016-04","conditions":"Induction of Labor","enrollment":320},{"nctId":"NCT01323205","phase":"PHASE2","title":"Investigation of the Safety, Tolerability and Potential Therapeutic Effects of JNJ-40411813 in Patients With Schizophrenia","status":"COMPLETED","sponsor":"Janssen Research & Development, LLC","startDate":"2011-05","conditions":"Schizophrenia","enrollment":100}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":30,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Metformin","Glimepiride","Sitagliptin"],"phase":"phase_3","status":"active","brandName":"Stepwise add-on therapy","genericName":"Stepwise add-on therapy","companyName":"Korea University Anam Hospital","companyId":"korea-university-anam-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":9,"withResults":3},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":true,"score":2}}