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Standard Volume Simethicone
Simethicone reduces surface tension of gas bubbles in the gastrointestinal tract, allowing them to coalesce and be expelled more easily.
Simethicone reduces surface tension of gas bubbles in the gastrointestinal tract, allowing them to coalesce and be expelled more easily. Used for Bloating and gas-related abdominal discomfort, Post-procedure gas relief (endoscopy, colonoscopy).
At a glance
| Generic name | Standard Volume Simethicone |
|---|---|
| Sponsor | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's |
| Drug class | Antifoaming agent |
| Modality | Small molecule |
| Therapeutic area | Gastroenterology |
| Phase | FDA-approved |
Mechanism of action
Simethicone is a silicone-based antifoaming agent that works as a surfactant to break down foam and reduce the surface tension of gas bubbles in the stomach and intestines. By coalessing smaller bubbles into larger ones, it facilitates their passage through the GI tract and reduces bloating, pressure, and discomfort. It is not absorbed systemically and acts locally within the gastrointestinal lumen.
Approved indications
- Bloating and gas-related abdominal discomfort
- Post-procedure gas relief (endoscopy, colonoscopy)
Common side effects
- Flatulence
- Abdominal discomfort
- Nausea
Key clinical trials
- High Volume Simethicone VCE Clinical Trial (PHASE4)
- Small Bowel Cleansing for Capsule Endoscopy in Pediatric Patients (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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