{"id":"standard-volume-simethicone","safety":{"commonSideEffects":[{"rate":null,"effect":"Flatulence"},{"rate":null,"effect":"Abdominal discomfort"},{"rate":null,"effect":"Nausea"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Simethicone is a silicone-based antifoaming agent that works as a surfactant to break down foam and reduce the surface tension of gas bubbles in the stomach and intestines. By coalessing smaller bubbles into larger ones, it facilitates their passage through the GI tract and reduces bloating, pressure, and discomfort. It is not absorbed systemically and acts locally within the gastrointestinal lumen.","oneSentence":"Simethicone reduces surface tension of gas bubbles in the gastrointestinal tract, allowing them to coalesce and be expelled more easily.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:09:33.854Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Bloating and gas-related abdominal discomfort"},{"name":"Post-procedure gas relief (endoscopy, colonoscopy)"}]},"trialDetails":[{"nctId":"NCT02334631","phase":"PHASE4","title":"High Volume Simethicone VCE Clinical Trial","status":"COMPLETED","sponsor":"London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's","startDate":"2017-01","conditions":"Small Bowel Diseases","enrollment":159},{"nctId":"NCT01783782","phase":"PHASE4","title":"Small Bowel Cleansing for Capsule Endoscopy in Pediatric Patients","status":"UNKNOWN","sponsor":"Azienda Policlinico Umberto I","startDate":"2005-11","conditions":"Capsule Endoscopy","enrollment":200}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":13,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Standard Volume Simethicone","genericName":"Standard Volume Simethicone","companyName":"London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's","companyId":"london-health-sciences-centre-research-institute-or-lawson-research-institute-of","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Simethicone reduces surface tension of gas bubbles in the gastrointestinal tract, allowing them to coalesce and be expelled more easily. Used for Bloating and gas-related abdominal discomfort, Post-procedure gas relief (endoscopy, colonoscopy).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}