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Standard of Care Oral antipsychotics
Standard of Care Oral antipsychotics is a Antipsychotic Small molecule drug developed by University of Utah. It is currently FDA-approved for Schizophrenia, Bipolar disorder, Psychotic disorders.
Standard of care oral antipsychotics block dopamine and/or serotonin receptors in the brain to reduce psychotic symptoms and stabilize mood.
Standard of care oral antipsychotics block dopamine and/or serotonin receptors in the brain to reduce psychotic symptoms and stabilize mood. Used for Schizophrenia, Bipolar disorder, Psychotic disorders.
At a glance
| Generic name | Standard of Care Oral antipsychotics |
|---|---|
| Sponsor | University of Utah |
| Drug class | Antipsychotic |
| Target | Dopamine D2 receptor; Serotonin 5-HT2A receptor |
| Modality | Small molecule |
| Therapeutic area | Psychiatry |
| Phase | FDA-approved |
Mechanism of action
Oral antipsychotics work primarily through antagonism of dopamine D2 receptors, which reduces hyperactivity in dopaminergic pathways associated with psychosis. Many also have serotonin 5-HT2A receptor antagonism, which contributes to antipsychotic and mood-stabilizing effects. The class includes both first-generation (typical) agents that are primarily dopamine antagonists and second-generation (atypical) agents with broader receptor profiles.
Approved indications
- Schizophrenia
- Bipolar disorder
- Psychotic disorders
- Acute agitation in psychiatric patients
Common side effects
- Extrapyramidal symptoms (tremor, rigidity, akathisia)
- Weight gain
- Metabolic syndrome (hyperglycemia, dyslipidemia)
- Sedation
- Prolactin elevation
- Orthostatic hypotension
- QT prolongation
Key clinical trials
- A Study of ANAVEX3-71 in Adults With Schizophrenia (PHASE2)
- A Study to Assess the Treatment of Schizophrenia With Paliperidone Palmitate in Rwandan Healthcare Settings (PHASE4)
- Impact of Aripiprazole Once Monthly Medications on Changes in Brain Structure and Metabolism (PHASE4)
- A Clinical Study That Will Assess How Food Moves Through the Stomach and Effects Blood Glucose Levels in Subjects With Schizophrenia Taking SEP-363856 or and Prior Antipsychotic (PA) Standard (PHASE1)
- A Clinical Study That Will Assess the Effect of SEP-363856 or Prior Antipsychotic (PA) Standard of Care on Body-weight Associated Parameters in Subjects With Schizophrenia (PHASE1)
- Networked Drug REpurposing for Mechanism-based neuroPrOtection in Acute Ischaemic STROKE (PHASE2)
- A Safety Study Comparing LY2140023 to Atypical Antipsychotic Standard Treatment in Schizophrenic Patients (PHASE2)
- A Study of LY2140023 in Schizophrenia Patients With Prominent Negative Symptoms (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Standard of Care Oral antipsychotics CI brief — competitive landscape report
- Standard of Care Oral antipsychotics updates RSS · CI watch RSS
- University of Utah portfolio CI
Frequently asked questions about Standard of Care Oral antipsychotics
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Related
- Drug class: All Antipsychotic drugs
- Target: All drugs targeting Dopamine D2 receptor; Serotonin 5-HT2A receptor
- Manufacturer: University of Utah — full pipeline
- Therapeutic area: All drugs in Psychiatry
- Indication: Drugs for Schizophrenia
- Indication: Drugs for Bipolar disorder
- Indication: Drugs for Psychotic disorders
- Compare: Standard of Care Oral antipsychotics vs similar drugs
- Pricing: Standard of Care Oral antipsychotics cost, discount & access