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Standard-of-care corticosteroid injections
Standard-of-care corticosteroid injections is a corticosteroid Small molecule drug developed by Rhode Island Hospital. It is currently in Phase 3 development for Treatment of various inflammatory conditions, including rheumatoid arthritis, asthma, and multiple sclerosis.
Corticosteroids reduce inflammation by inhibiting the production of pro-inflammatory cytokines and mediators.
Corticosteroids reduce inflammation by inhibiting the production of pro-inflammatory cytokines and mediators. Used for Treatment of various inflammatory conditions, including rheumatoid arthritis, asthma, and multiple sclerosis.
At a glance
| Generic name | Standard-of-care corticosteroid injections |
|---|---|
| Sponsor | Rhode Island Hospital |
| Drug class | corticosteroid |
| Target | Glucocorticoid receptor |
| Modality | Small molecule |
| Therapeutic area | Immunology |
| Phase | Phase 3 |
Mechanism of action
They do this by binding to and activating glucocorticoid receptors, which then translocate to the nucleus and regulate the expression of genes involved in the inflammatory response. This results in a decrease in the production of pro-inflammatory cytokines and mediators, leading to reduced inflammation.
Approved indications
- Treatment of various inflammatory conditions, including rheumatoid arthritis, asthma, and multiple sclerosis
Common side effects
- Adrenal insufficiency
- Osteoporosis
- Glaucoma
- Cataracts
- Hypertension
Key clinical trials
- pAF for the Treatment of Osteoarthritis (PHASE1, PHASE2)
- A Study of Lebrikizumab in Adult Participants With Perennial Allergic Rhinitis (PREPARED-1) (PHASE3)
- A Study of Lebrikizumab (LY3650150) in Participants With Chronic Rhinosinusitis and Nasal Polyps Treated With Intranasal Corticosteroids (CONTRAST-NP) (PHASE3)
- Study of Efficacy, Safety, Tolerability, Pharmacokinetic (PK) and Pharmacodynamic (PD) of an Anti-CD40 Monoclonal Antibody, CFZ533, in Kidney Transplant Recipients (PHASE2)
- A Study of Lorigerlimab With Docetaxel or Docetaxel Alone in Participants With Metastatic Castration-Resistant Prostate Cancer (PHASE2)
- The Efficacy and Safety of Biologics (Belimumab/ Telitacicept) Induction Therapy in Proliferative Lupus Nephritis Patients for 6 Months Compared With Mycophenolate Mofetil Treatment (PHASE2)
- Structured Review: To Optimise Management and Prevent Harm in COPD (NA)
- Knee Injections for Obese Patients With Knee Arthritis (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Standard-of-care corticosteroid injections CI brief — competitive landscape report
- Standard-of-care corticosteroid injections updates RSS · CI watch RSS
- Rhode Island Hospital portfolio CI
Frequently asked questions about Standard-of-care corticosteroid injections
What is Standard-of-care corticosteroid injections?
How does Standard-of-care corticosteroid injections work?
What is Standard-of-care corticosteroid injections used for?
Who makes Standard-of-care corticosteroid injections?
What drug class is Standard-of-care corticosteroid injections in?
What development phase is Standard-of-care corticosteroid injections in?
What are the side effects of Standard-of-care corticosteroid injections?
What does Standard-of-care corticosteroid injections target?
Related
- Drug class: All corticosteroid drugs
- Target: All drugs targeting Glucocorticoid receptor
- Manufacturer: Rhode Island Hospital — full pipeline
- Therapeutic area: All drugs in Immunology
- Indication: Drugs for Treatment of various inflammatory conditions, including rheumatoid arthritis, asthma, and multiple sclerosis
- Compare: Standard-of-care corticosteroid injections vs similar drugs
- Pricing: Standard-of-care corticosteroid injections cost, discount & access