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standard IV treatment for headache
Sumatriptan works by binding to serotonin receptors, specifically 5-HT1B and 5-HT1D receptors, to induce vasoconstriction and inhibit pro-inflammatory neuropeptide release.
Sumatriptan works by binding to serotonin receptors, specifically 5-HT1B and 5-HT1D receptors, to induce vasoconstriction and inhibit pro-inflammatory neuropeptide release. Used for Acute treatment of migraine attacks with or without aura, Prevention of migraine headaches.
At a glance
| Generic name | standard IV treatment for headache |
|---|---|
| Sponsor | HCA Florida North Florida Hospital |
| Drug class | Triptan |
| Target | 5-HT1B, 5-HT1D |
| Modality | Small molecule |
| Therapeutic area | Neurology |
| Phase | Phase 3 |
Mechanism of action
This action leads to the relief of migraine headache symptoms. The exact mechanism of action is not fully understood, but it is thought to involve the inhibition of pro-inflammatory neuropeptide release and the induction of vasoconstriction.
Approved indications
- Acute treatment of migraine attacks with or without aura
- Prevention of migraine headaches
Common side effects
- Dizziness
- Nausea
- Headache
- Flushing
- Tingling
Key clinical trials
- Boosting Olfactory and Sensory Training Study (BOOST) (EARLY_PHASE1)
- Does a Periaqueductal Gray-vagus Nerve Interface Malfunction Explain the Nat hx With Its Numerous Co-morbidities?
- 0.5% Bupivacaine Lower Cervical Intramuscular Injection vs IV Medications for Headache Treatment (PHASE3)
- Arginine Replacement Therapy in COVID-19 (PHASE2)
- Spenopalatine Ganglion Block for Treatment of Post-dural Puncture Headaches (NA)
- Olanzapine for Acute Headaches (PHASE4)
- SPG Blocks for Headaches (PHASE4)
- Postoperative Pain and Headache After Craniotomy (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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