{"id":"standard-iv-treatment-for-headache","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Dizziness"},{"rate":"10-20%","effect":"Nausea"},{"rate":"5-10%","effect":"Headache"},{"rate":"5-10%","effect":"Flushing"},{"rate":"5-10%","effect":"Tingling"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"This action leads to the relief of migraine headache symptoms. The exact mechanism of action is not fully understood, but it is thought to involve the inhibition of pro-inflammatory neuropeptide release and the induction of vasoconstriction.","oneSentence":"Sumatriptan works by binding to serotonin receptors, specifically 5-HT1B and 5-HT1D receptors, to induce vasoconstriction and inhibit pro-inflammatory neuropeptide release.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:53:33.430Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute treatment of migraine attacks with or without aura"},{"name":"Prevention of migraine headaches"}]},"trialDetails":[{"nctId":"NCT07221123","phase":"EARLY_PHASE1","title":"Boosting Olfactory and Sensory Training Study (BOOST)","status":"NOT_YET_RECRUITING","sponsor":"University of Alabama at Birmingham","startDate":"2026-05-01","conditions":"HIV (Human Immunodeficiency Virus)","enrollment":80},{"nctId":"NCT06616363","phase":"","title":"Does a Periaqueductal Gray-vagus Nerve Interface Malfunction Explain the Nat hx With Its Numerous Co-morbidities?","status":"RECRUITING","sponsor":"Virginia Commonwealth University","startDate":"2024-05-29","conditions":"POTS - Postural Orthostatic Tachycardia Syndrome","enrollment":120},{"nctId":"NCT06937385","phase":"PHASE3","title":"0.5% Bupivacaine Lower Cervical Intramuscular Injection vs IV Medications for Headache Treatment","status":"NOT_YET_RECRUITING","sponsor":"HCA Florida North Florida Hospital","startDate":"2025-05-01","conditions":"Headache, Migraine, Tension Headache","enrollment":100},{"nctId":"NCT05855330","phase":"PHASE2","title":"Arginine Replacement Therapy in COVID-19","status":"RECRUITING","sponsor":"Emory University","startDate":"2024-01-08","conditions":"COVID-19","enrollment":21},{"nctId":"NCT04515901","phase":"NA","title":"Spenopalatine Ganglion Block for Treatment of Post-dural Puncture Headaches","status":"WITHDRAWN","sponsor":"McMaster University","startDate":"2021-12-01","conditions":"Postdural Puncture Headache","enrollment":""},{"nctId":"NCT03066622","phase":"PHASE4","title":"Olanzapine for Acute Headaches","status":"COMPLETED","sponsor":"HealthPartners Institute","startDate":"2016-07","conditions":"Headache","enrollment":122},{"nctId":"NCT04255420","phase":"PHASE4","title":"SPG Blocks for Headaches","status":"UNKNOWN","sponsor":"Kendall Healthcare Group, Ltd.","startDate":"2020-02-21","conditions":"Headache","enrollment":84},{"nctId":"NCT03908944","phase":"PHASE2","title":"Postoperative Pain and Headache After Craniotomy","status":"WITHDRAWN","sponsor":"Steven Edelstein","startDate":"2019-01-02","conditions":"Postoperative Pain","enrollment":""},{"nctId":"NCT01604785","phase":"PHASE2, PHASE3","title":"Low-dose Propofol for Pediatric Migraine","status":"COMPLETED","sponsor":"Oregon Health and Science University","startDate":"2012-11","conditions":"Migraine Headache","enrollment":74},{"nctId":"NCT03512977","phase":"NA","title":"Is Sphenopalatine Ganglion Block Treatment Effective on Postspinal Headaches","status":"COMPLETED","sponsor":"Derince Training and Research Hospital","startDate":"2017-12-01","conditions":"Headache Disorders, Central Nervous System Diseases","enrollment":20},{"nctId":"NCT02295280","phase":"NA","title":"A Cost Effective Treatment for Headache in Pregnancy When Acetaminophen Alone is Ineffective.","status":"COMPLETED","sponsor":"St. Louis University","startDate":"2012-01","conditions":"Headache","enrollment":70}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":10,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"standard IV treatment for headache","genericName":"standard IV treatment for headache","companyName":"HCA Florida North Florida Hospital","companyId":"hca-florida-north-florida-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Sumatriptan works by binding to serotonin receptors, specifically 5-HT1B and 5-HT1D receptors, to induce vasoconstriction and inhibit pro-inflammatory neuropeptide release. Used for Acute treatment of migraine attacks with or without aura, Prevention of migraine headaches.","enrichmentLevel":3,"visitCount":2,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}