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Sonovue and Sonazoid
Sonovue and Sonazoid are ultrasound contrast agents that enhance echocardiographic and ultrasound imaging by producing microbubbles that reflect ultrasound waves.
Sonovue and Sonazoid are ultrasound contrast agents that enhance echocardiographic and ultrasound imaging by producing microbubbles that reflect ultrasound waves. Used for Echocardiographic contrast enhancement for left ventricular opacification, Myocardial perfusion imaging, Cardiac structure and function assessment.
At a glance
| Generic name | Sonovue and Sonazoid |
|---|---|
| Sponsor | Second Affiliated Hospital, School of Medicine, Zhejiang University |
| Drug class | Ultrasound contrast agent |
| Modality | Small molecule |
| Therapeutic area | Cardiology / Diagnostic Imaging |
| Phase | Phase 3 |
Mechanism of action
These agents consist of gas-filled microbubbles stabilized by a shell (lipid or protein-based) that circulate through the bloodstream and dramatically increase ultrasound signal reflection, improving visualization of cardiac chambers, myocardial perfusion, and vascular structures. The microbubbles enhance contrast between blood and tissue, enabling better detection of cardiac abnormalities, perfusion defects, and structural lesions during ultrasound imaging.
Approved indications
- Echocardiographic contrast enhancement for left ventricular opacification
- Myocardial perfusion imaging
- Cardiac structure and function assessment
Common side effects
- Headache
- Flushing
- Chest discomfort
- Dyspnea
Key clinical trials
- Y-90 Treatment Response Using Transarterial Radioembolization (PHASE2)
- Value of Super-resolution Ultrasonography in Differentiating Benign and Malignant Lymph Nodes
- SHAPE of Portal Hypertension in Children (PHASE2)
- Comparing SonoVue With Sonazoid Using CEUS-LIRADS in HCC (PHASE3)
- An Efficacy and Safety Study of Sonazoid™ and SonoVue® in Participants With Focal Liver Lesions, Undergoing Pre- and Post-Contrast Ultrasound Imaging (PHASE3)
- Contrast-Enhanced Intraoperative Ultrasound During Liver Surgery for Colorectal Cancer Liver Metastases
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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