{"id":"sonovue-and-sonazoid","safety":{"commonSideEffects":[{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Flushing"},{"rate":null,"effect":"Chest discomfort"},{"rate":null,"effect":"Dyspnea"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"anthropic-haiku","explanation":"These agents consist of gas-filled microbubbles stabilized by a shell (lipid or protein-based) that circulate through the bloodstream and dramatically increase ultrasound signal reflection, improving visualization of cardiac chambers, myocardial perfusion, and vascular structures. The microbubbles enhance contrast between blood and tissue, enabling better detection of cardiac abnormalities, perfusion defects, and structural lesions during ultrasound imaging.","oneSentence":"Sonovue and Sonazoid are ultrasound contrast agents that enhance echocardiographic and ultrasound imaging by producing microbubbles that reflect ultrasound waves.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:35:22.690Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Echocardiographic contrast enhancement for left ventricular opacification"},{"name":"Myocardial perfusion imaging"},{"name":"Cardiac structure and function assessment"}]},"trialDetails":[{"nctId":"NCT07145801","phase":"PHASE2","title":"Y-90 Treatment Response Using Transarterial Radioembolization","status":"RECRUITING","sponsor":"Thomas Jefferson University","startDate":"2025-09-11","conditions":"HCC, Hepatocellular Carcinoma, Liver Cancer","enrollment":30},{"nctId":"NCT07155954","phase":"","title":"Value of Super-resolution Ultrasonography in Differentiating Benign and Malignant Lymph Nodes","status":"RECRUITING","sponsor":"Peking University Third Hospital","startDate":"2024-10-23","conditions":"Lymphadenopathy, Lymphnode Metastasis, Lymphoma","enrollment":779},{"nctId":"NCT04720456","phase":"PHASE2","title":"SHAPE of Portal Hypertension in Children","status":"RECRUITING","sponsor":"Thomas Jefferson University","startDate":"2021-11-03","conditions":"Hypertension, Portal","enrollment":120},{"nctId":"NCT04006275","phase":"PHASE3","title":"Comparing SonoVue With Sonazoid Using CEUS-LIRADS in HCC","status":"UNKNOWN","sponsor":"Second Affiliated Hospital, School of Medicine, Zhejiang University","startDate":"2019-06-30","conditions":"Hepatocellular Carcinoma, Cirrhosis","enrollment":100},{"nctId":"NCT03335566","phase":"PHASE3","title":"An Efficacy and Safety Study of Sonazoid™ and SonoVue® in Participants With Focal Liver Lesions, Undergoing Pre- and Post-Contrast Ultrasound Imaging","status":"COMPLETED","sponsor":"GE Healthcare","startDate":"2014-05-11","conditions":"Liver Lesions","enrollment":424},{"nctId":"NCT01526200","phase":"","title":"Contrast-Enhanced Intraoperative Ultrasound During Liver Surgery for Colorectal Cancer Liver Metastases","status":"COMPLETED","sponsor":"University of Milan","startDate":"2007-10","conditions":"Colon Cancer Liver Metastasis","enrollment":127}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":58,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Sonovue and Sonazoid","genericName":"Sonovue and Sonazoid","companyName":"Second Affiliated Hospital, School of Medicine, Zhejiang University","companyId":"second-affiliated-hospital-school-of-medicine-zhejiang-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Sonovue and Sonazoid are ultrasound contrast agents that enhance echocardiographic and ultrasound imaging by producing microbubbles that reflect ultrasound waves. Used for Echocardiographic contrast enhancement for left ventricular opacification, Myocardial perfusion imaging, Cardiac structure and function assessment.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}