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Sodium Picosulfate/Magnesium Citrate Laxative
Sodium picosulfate is converted by colonic bacteria to bis-(p-hydroxyphenyl)-pyridyl-methane, which stimulates colonic contractions, while magnesium citrate acts as an osmotic laxative to draw water into the bowel.
Sodium picosulfate is converted by colonic bacteria to bis-(p-hydroxyphenyl)-pyridyl-methane, which stimulates colonic contractions, while magnesium citrate acts as an osmotic laxative to draw water into the bowel. Used for Bowel cleansing prior to colonoscopy or other gastrointestinal procedures, Constipation management.
At a glance
| Generic name | Sodium Picosulfate/Magnesium Citrate Laxative |
|---|---|
| Also known as | (Citrafleet®) |
| Sponsor | American University of Beirut Medical Center |
| Drug class | Osmotic and stimulant laxative combination |
| Modality | Small molecule |
| Therapeutic area | Gastroenterology |
| Phase | FDA-approved |
Mechanism of action
Sodium picosulfate is a prodrug that undergoes bacterial metabolism in the colon to produce an active metabolite that stimulates colonic smooth muscle contractions and increases intestinal motility. Magnesium citrate functions as an osmotic agent, increasing intraluminal fluid volume and promoting bowel evacuation. Together, these agents produce a synergistic laxative effect suitable for bowel cleansing.
Approved indications
- Bowel cleansing prior to colonoscopy or other gastrointestinal procedures
- Constipation management
Common side effects
- Abdominal pain or cramping
- Nausea
- Vomiting
- Diarrhea
- Headache
- Dizziness
Key clinical trials
- Study Assessing CLENPIQ as Bowel Preparation for Pediatric Colonoscopy (PHASE1, PHASE2)
- Efficacy, Tolerance and Safety of Split Dose Bowel Preparation for Colonoscopy: 4L Polyethylene Glycol (PEG) Versus 1L Polyethylene Glycol Plus Sodium Picosulfate-magnesium Citrate (SPMC) (PHASE4)
- A Trial to Compare Efficacy and Tolerability of Plenvu® and Picoprep® as Cleansing Agents Before Colonoscopy (PHASE4)
- Comparing Sennosid A+B and Sodium Picosulfate/Magnesium Oxide/Citric Acid for Bowel Preparation (PHASE4)
- Short-term Effects of Bowel Preparation on Gut Microbiome in Patients Undergoing Endoscopic Colon Polypectomy (PHASE4)
- Preoperative Oral Antibiotics With vs Without Mechanical Bowel Preparation to Reduce Surgical Site Infections Following Colonic Resection: an International Randomized Controlled Trial. (PHASE4)
- Bowel Preparation in Elective Pediatric Colorectal Surgery (NA)
- Comparison of 1 Liter PEG With Ascorbate and Sodium Picosulfate / Magnesium Citrate for High Quality Colon Cleansing (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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