{"id":"sodium-picosulfate-magnesium-citrate-laxative","safety":{"commonSideEffects":[{"rate":"10-30%","effect":"Abdominal pain or cramping"},{"rate":"5-15%","effect":"Nausea"},{"rate":"2-10%","effect":"Vomiting"},{"rate":"common (expected therapeutic effect)","effect":"Diarrhea"},{"rate":"5-10%","effect":"Headache"},{"rate":"2-5%","effect":"Dizziness"}]},"_chembl":{"chemblId":"CHEMBL1697768","moleculeType":"Small molecule","molecularWeight":"481.42"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Sodium picosulfate is a prodrug that undergoes bacterial metabolism in the colon to produce an active metabolite that stimulates colonic smooth muscle contractions and increases intestinal motility. Magnesium citrate functions as an osmotic agent, increasing intraluminal fluid volume and promoting bowel evacuation. Together, these agents produce a synergistic laxative effect suitable for bowel cleansing.","oneSentence":"Sodium picosulfate is converted by colonic bacteria to bis-(p-hydroxyphenyl)-pyridyl-methane, which stimulates colonic contractions, while magnesium citrate acts as an osmotic laxative to draw water into the bowel.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:08:32.901Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Bowel cleansing prior to colonoscopy or other gastrointestinal procedures"},{"name":"Constipation management"}]},"trialDetails":[{"nctId":"NCT04113382","phase":"PHASE1, PHASE2","title":"Study Assessing CLENPIQ as Bowel Preparation for Pediatric Colonoscopy","status":"RECRUITING","sponsor":"Ferring Pharmaceuticals","startDate":"2022-06-23","conditions":"Bowel Preparation","enrollment":30},{"nctId":"NCT04474002","phase":"PHASE4","title":"Efficacy, Tolerance and Safety of Split Dose Bowel Preparation for Colonoscopy: 4L Polyethylene Glycol (PEG) Versus 1L Polyethylene Glycol Plus Sodium Picosulfate-magnesium Citrate (SPMC)","status":"COMPLETED","sponsor":"Queen Elizabeth Hospital, Hong Kong","startDate":"2020-12-07","conditions":"Bowel Preparation Solutions, Colonoscopy","enrollment":158},{"nctId":"NCT05436054","phase":"PHASE4","title":"A Trial to Compare Efficacy and Tolerability of Plenvu® and Picoprep® as Cleansing Agents Before Colonoscopy","status":"RECRUITING","sponsor":"Aalborg University Hospital","startDate":"2022-10-01","conditions":"Colon Disease","enrollment":400},{"nctId":"NCT06580366","phase":"PHASE4","title":"Comparing Sennosid A+B and Sodium Picosulfate/Magnesium Oxide/Citric Acid for Bowel Preparation","status":"NOT_YET_RECRUITING","sponsor":"Hitit University","startDate":"2024-08-22","conditions":"Bowel Preparation","enrollment":600},{"nctId":"NCT06339697","phase":"PHASE4","title":"Short-term Effects of Bowel Preparation on Gut Microbiome in Patients Undergoing Endoscopic Colon Polypectomy","status":"COMPLETED","sponsor":"Zhang Yanli","startDate":"2022-12-01","conditions":"Colon Polyp, Cathartic Colon","enrollment":194},{"nctId":"NCT04161599","phase":"PHASE4","title":"Preoperative Oral Antibiotics With vs Without Mechanical Bowel Preparation to Reduce Surgical Site Infections Following Colonic Resection: an International Randomized Controlled Trial.","status":"UNKNOWN","sponsor":"Hospital Universitari Vall d'Hebron Research Institute","startDate":"2022-03-01","conditions":"Wounds and Injuries, Surgery--Complications","enrollment":968},{"nctId":"NCT03593252","phase":"NA","title":"Bowel Preparation in Elective Pediatric Colorectal Surgery","status":"UNKNOWN","sponsor":"McMaster University","startDate":"2022-01-01","conditions":"Colostomy, Hirschsprung Disease - Pull Through, Necrotizing Enterocolitis","enrollment":81},{"nctId":"NCT04598880","phase":"PHASE4","title":"Comparison of 1 Liter PEG With Ascorbate and Sodium Picosulfate / Magnesium Citrate for High Quality Colon Cleansing","status":"UNKNOWN","sponsor":"Parc de Salut Mar","startDate":"2020-11-06","conditions":"Colonic Diseases","enrollment":1104},{"nctId":"NCT03581149","phase":"PHASE4","title":"Tolerability and Efficacy of Sodium Picosulfate/Magnesium Citrate Versus PEG/Ascorbic Acid in Ulcerative Colitis Patients","status":"UNKNOWN","sponsor":"American University of Beirut Medical Center","startDate":"2018-03-26","conditions":"Ulcerative Colitis","enrollment":68},{"nctId":"NCT02124447","phase":"NA","title":"Single Center Comparison of 4 FDA Approved, Commercially Available Bowel Purgatives for Colonoscopy","status":"WITHDRAWN","sponsor":"Medical College of Wisconsin","startDate":"2014-06","conditions":"Patients Undergoing Screening or Surveillance Colonoscopy","enrollment":""}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":18,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["(Citrafleet®)"],"phase":"marketed","status":"active","brandName":"Sodium Picosulfate/Magnesium Citrate Laxative","genericName":"Sodium Picosulfate/Magnesium Citrate Laxative","companyName":"American University of Beirut Medical Center","companyId":"american-university-of-beirut-medical-center","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Sodium picosulfate is converted by colonic bacteria to bis-(p-hydroxyphenyl)-pyridyl-methane, which stimulates colonic contractions, while magnesium citrate acts as an osmotic laxative to draw water into the bowel. Used for Bowel cleansing prior to colonoscopy or other gastrointestinal procedures, Constipation management.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}