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Sodium monofluorophosphate dentifrice
Sodium monofluorophosphate releases fluoride ions in the oral cavity to strengthen tooth enamel and inhibit bacterial acid production, preventing dental caries.
Sodium monofluorophosphate releases fluoride ions in the oral cavity to strengthen tooth enamel and inhibit bacterial acid production, preventing dental caries. Used for Dental caries prevention, Tooth enamel strengthening.
At a glance
| Generic name | Sodium monofluorophosphate dentifrice |
|---|---|
| Sponsor | Procter and Gamble |
| Drug class | Fluoride dentifrice |
| Target | Tooth enamel hydroxyapatite; bacterial enolase |
| Modality | Small molecule |
| Therapeutic area | Dental/Oral Health |
| Phase | FDA-approved |
Mechanism of action
Fluoride ions are incorporated into the hydroxyapatite crystal structure of tooth enamel, making it more resistant to demineralization by acids produced by cariogenic bacteria. Additionally, fluoride inhibits enolase in bacterial glycolytic pathways, reducing acid production and bacterial adhesion. This dual mechanism provides both remineralization and antimicrobial benefits for cavity prevention.
Approved indications
- Dental caries prevention
- Tooth enamel strengthening
Common side effects
- Dental fluorosis (with excessive ingestion, particularly in children)
- Mild oral irritation or sensitivity
Key clinical trials
- The Clinical of Stannous Fluoride Toothpaste and a Newly Designed Toothbrush Compared to Colgate Cavity Protection Toothpaste and a Regular Toothbrush in Reducing Plaque and Gingivitis. (PHASE3)
- A Study to Investigate Stannous Fluoride Containing Toothpaste on Antibacterial Effects in the Different Regions of the Mouth (PHASE3)
- Efficacy of a Stannous Fluoride Toothpaste, Cetylpyridinium Chloride Mouthwash, and Battery Toothbrush Regimen in Reducing Established Dental Plaque and Gingivitis. (PHASE3)
- A Clinical Study Investigating the Efficacy of an Experimental Toothpaste Containing Stannous Fluoride in Improving Gingival Health (NA)
- Study to Evaluate the Effectiveness of Test Dentifrice in the Relief of Dentinal Hypersensitivity (NA)
- Efficacy of Toothpaste Containing 0.454% Stannous Fluoride as Compared to a Regular Fluoride Toothpaste Containing 0.76% Sodium Monofluorophosphate in Controlling Supragingival Calculus Formation Over a 12-week Period. (PHASE2, PHASE3)
- A Clinical Study Conducted in the Bangkok, Thailand Area, to Investigate the Clinical Efficacy of a New Toothpaste (PHASE3)
- Comparative Efficacy of Floss and Essential Oil/CPC+Zn Mouthwashes in Reducing Dental Plaque and Gingivitis (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |