{"id":"sodium-monofluorophosphate-dentifrice","safety":{"commonSideEffects":[{"rate":null,"effect":"Dental fluorosis (with excessive ingestion, particularly in children)"},{"rate":null,"effect":"Mild oral irritation or sensitivity"}]},"_chembl":{"chemblId":"CHEMBL1908359","moleculeType":"Small molecule","molecularWeight":"143.95"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Fluoride ions are incorporated into the hydroxyapatite crystal structure of tooth enamel, making it more resistant to demineralization by acids produced by cariogenic bacteria. Additionally, fluoride inhibits enolase in bacterial glycolytic pathways, reducing acid production and bacterial adhesion. This dual mechanism provides both remineralization and antimicrobial benefits for cavity prevention.","oneSentence":"Sodium monofluorophosphate releases fluoride ions in the oral cavity to strengthen tooth enamel and inhibit bacterial acid production, preventing dental caries.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:08:31.645Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Dental caries prevention"},{"name":"Tooth enamel strengthening"}]},"trialDetails":[{"nctId":"NCT06427499","phase":"PHASE3","title":"The Clinical of Stannous Fluoride Toothpaste and a Newly Designed Toothbrush Compared to Colgate Cavity Protection Toothpaste and a Regular Toothbrush in Reducing Plaque and Gingivitis.","status":"COMPLETED","sponsor":"Colgate Palmolive","startDate":"2024-04-22","conditions":"Plaque, Gingivitis","enrollment":95},{"nctId":"NCT07458464","phase":"PHASE3","title":"A Study to Investigate Stannous Fluoride Containing Toothpaste on Antibacterial Effects in the Different Regions of the Mouth","status":"NOT_YET_RECRUITING","sponsor":"Colgate Palmolive","startDate":"2026-05","conditions":"Plaque, Gingivitis","enrollment":100},{"nctId":"NCT07398846","phase":"PHASE3","title":"Efficacy of a Stannous Fluoride Toothpaste, Cetylpyridinium Chloride Mouthwash, and Battery Toothbrush Regimen in Reducing Established Dental Plaque and Gingivitis.","status":"RECRUITING","sponsor":"Colgate Palmolive","startDate":"2026-01-26","conditions":"Plaque","enrollment":135},{"nctId":"NCT07169188","phase":"NA","title":"A Clinical Study Investigating the Efficacy of an Experimental Toothpaste Containing Stannous Fluoride in Improving Gingival Health","status":"COMPLETED","sponsor":"HALEON","startDate":"2025-09-09","conditions":"Dental Plaque, Gingivitis","enrollment":154},{"nctId":"NCT07317128","phase":"NA","title":"Study to Evaluate the Effectiveness of Test Dentifrice in the Relief of Dentinal Hypersensitivity","status":"COMPLETED","sponsor":"HALEON","startDate":"2013-01-20","conditions":"Dentin Sensitivity","enrollment":120},{"nctId":"NCT07223060","phase":"PHASE2, PHASE3","title":"Efficacy of Toothpaste Containing 0.454% Stannous Fluoride as Compared to a Regular Fluoride Toothpaste Containing 0.76% Sodium Monofluorophosphate in Controlling Supragingival Calculus Formation Over a 12-week Period.","status":"COMPLETED","sponsor":"Colgate Palmolive","startDate":"2017-05-17","conditions":"Calculus, Dental","enrollment":100},{"nctId":"NCT07223073","phase":"PHASE3","title":"A Clinical Study Conducted in the Bangkok, Thailand Area, to Investigate the Clinical Efficacy of a New Toothpaste","status":"COMPLETED","sponsor":"Colgate Palmolive","startDate":"2017-12-21","conditions":"Oral Malodor","enrollment":80},{"nctId":"NCT07029438","phase":"PHASE4","title":"Comparative Efficacy of Floss and Essential Oil/CPC+Zn Mouthwashes in Reducing Dental Plaque and Gingivitis","status":"COMPLETED","sponsor":"Colgate Palmolive","startDate":"2025-07-07","conditions":"Dental Plaque, Gingivitis","enrollment":228},{"nctId":"NCT07158112","phase":"PHASE4","title":"Assessing Gingivitis and Plaque From a Marketed Toothpaste","status":"ACTIVE_NOT_RECRUITING","sponsor":"Procter and Gamble","startDate":"2025-08-30","conditions":"Gingivitis","enrollment":120},{"nctId":"NCT06048809","phase":"NA","title":"A Study to Evaluate the Effect of a Stannous Fluoride Toothpaste on the Oral Microbiome","status":"COMPLETED","sponsor":"HALEON","startDate":"2024-04-10","conditions":"Oral Health","enrollment":56},{"nctId":"NCT06892834","phase":"PHASE2","title":"Assessing Gingivitis of 3 Different Dentifrices Compared to a Negative Control.","status":"COMPLETED","sponsor":"Procter and Gamble","startDate":"2025-03-25","conditions":"Gingivitis","enrollment":120},{"nctId":"NCT06962956","phase":"PHASE1","title":"Evaluating Gingivitis and Systemic Biomarkers","status":"ACTIVE_NOT_RECRUITING","sponsor":"Procter and Gamble","startDate":"2025-04-30","conditions":"Gingivitis","enrollment":135},{"nctId":"NCT06800443","phase":"NA","title":"A Cosmetic Study to Measure the Change in Tooth Colour After Using Instant Whitening Prototypes Compared to a Negative Control","status":"COMPLETED","sponsor":"Unilever R&D","startDate":"2018-12-03","conditions":"Tooth Color","enrollment":68},{"nctId":"NCT05654662","phase":"NA","title":"A Clinical Study Investigating the Effects of a Dentifrice Containing 67% Sodium Bicarbonate When Used Twice Daily for 12 Weeks on Gingivitis Treatment and Plaque Removal","status":"COMPLETED","sponsor":"HALEON","startDate":"2023-02-20","conditions":"Gingivitis, Dental Plaque","enrollment":197},{"nctId":"NCT06659471","phase":"NA","title":"Brief Title: a Clinical Study to Assess Gingivitis","status":"COMPLETED","sponsor":"Procter and Gamble","startDate":"2022-03-07","conditions":"Gingival Diseases","enrollment":120},{"nctId":"NCT06128434","phase":"NA","title":"Effectiveness of Different Toothpastes in Treating White Spot Lesions","status":"UNKNOWN","sponsor":"Mansoura University","startDate":"2023-11-30","conditions":"White Spot Lesions [Initial Caries] on Smooth Surface of Tooth","enrollment":21},{"nctId":"NCT06353165","phase":"PHASE3","title":"Anti-bacterial Clinical Study on Teeth, Tongue, Cheek, Gum, and Saliva","status":"COMPLETED","sponsor":"Colgate Palmolive","startDate":"2023-03-08","conditions":"Plaque, Dental","enrollment":100},{"nctId":"NCT06300905","phase":"PHASE3","title":"Clinical Study on Malodor","status":"COMPLETED","sponsor":"Colgate Palmolive","startDate":"2023-06-01","conditions":"Oral Malodor","enrollment":100},{"nctId":"NCT06300866","phase":"PHASE3","title":"Gingivitis Reduction After Use of 0.45% Stannous Fluoride Toothpaste","status":"COMPLETED","sponsor":"Colgate Palmolive","startDate":"2020-08-18","conditions":"Gingivitis, Plaque, Dental","enrollment":80},{"nctId":"NCT06140784","phase":"NA","title":"A Clinical Study to Assess the Gingivitis and Plaque Effects of Various Dentifrices","status":"COMPLETED","sponsor":"Procter and Gamble","startDate":"2023-09-02","conditions":"Gingivitis","enrollment":116},{"nctId":"NCT06140758","phase":"NA","title":"Evaluation of the Anticaries Efficacy of Dentifrice Formulations Using an In-situ Model","status":"COMPLETED","sponsor":"Procter and Gamble","startDate":"2023-07-31","conditions":"Caries","enrollment":12},{"nctId":"NCT06197555","phase":"NA","title":"Comparision of the Clinical Efficacy of Different Desensitizing Toothpastes","status":"COMPLETED","sponsor":"Altinbas University","startDate":"2022-05-01","conditions":"Dentine Hypersensitivity","enrollment":48},{"nctId":"NCT06140771","phase":"NA","title":"A Clinical Study to Assess the Gingivitis Effects of Various Dentifrices","status":"COMPLETED","sponsor":"Procter and Gamble","startDate":"2021-10-20","conditions":"Gingivitis","enrollment":115},{"nctId":"NCT04006483","phase":"","title":"Meta-analysis of Stannous Fluoride and the Effects on Dental Plaque","status":"COMPLETED","sponsor":"Procter and Gamble","startDate":"2018-01-08","conditions":"Dental Plaque","enrollment":2359},{"nctId":"NCT03936569","phase":"PHASE4","title":"A Clinical Study to Assess the Plaque and Gingivitis Effects of a Stannous Fluoride Dentifrice","status":"COMPLETED","sponsor":"Procter and Gamble","startDate":"2018-10-29","conditions":"Gingivitis","enrollment":90},{"nctId":"NCT05731778","phase":"PHASE4","title":"Clinical Study to Assess Therapeutic Delay and Resolution of Induced Gingivitis","status":"COMPLETED","sponsor":"Colgate Palmolive","startDate":"2018-12-22","conditions":"Gingivitis","enrollment":26},{"nctId":"NCT05596149","phase":"NA","title":"Assessment of the Cytotoxic and Genotoxic Effect of Toothpastes With Different Forms of Fluoride on the Buccal Mucosa","status":"UNKNOWN","sponsor":"University of Zagreb","startDate":"2022-11-01","conditions":"DNA Damage","enrollment":80},{"nctId":"NCT04033575","phase":"PHASE4","title":"Clinical Investigation of a Toothpaste Containing Stannous Fluoride as Compared to Colgate Fluoride Toothpaste","status":"COMPLETED","sponsor":"Colgate Palmolive","startDate":"2019-03-06","conditions":"Gingivitis","enrollment":88},{"nctId":"NCT05375227","phase":"NA","title":"Assessment of a Sonic Toothbrush on the Abrasion of the Gingival Tissue","status":"UNKNOWN","sponsor":"Philips France Commercial","startDate":"2022-07-01","conditions":"Gingival Abrasion","enrollment":60},{"nctId":"NCT04537962","phase":"NA","title":"Salivary SARS-CoV-2 Load of Covid-19 Patients After Oral Antimicrobial Solutions and Dentifrices","status":"COMPLETED","sponsor":"Hospital Israelita Albert Einstein","startDate":"2020-07-14","conditions":"Corona Virus Infection","enrollment":202},{"nctId":"NCT04446390","phase":"NA","title":"Preventive Regimens With Herbal and Fluoride Toothpaste on Remineralization in High Caries Patients With Initial Lesions","status":"UNKNOWN","sponsor":"Cairo University","startDate":"2021-01-01","conditions":"Dental Caries","enrollment":32},{"nctId":"NCT03310268","phase":"NA","title":"A Clinical Study to Evaluate a Stannous Fluoride Toothpaste for the Relief of Dentinal Hypersensitivity","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2017-11-18","conditions":"Dentin Sensitivity","enrollment":185},{"nctId":"NCT03965039","phase":"NA","title":"A Clinical Study to Assess the Effects of Various Dentifrice Technologies on Dentinal Hypersensitivity","status":"COMPLETED","sponsor":"Procter and Gamble","startDate":"2019-07-08","conditions":"Dentin Hypersensitivity","enrollment":120},{"nctId":"NCT03244618","phase":"NA","title":"A Study to Measure the Efficacy of a Toothpaste on Dentinal Hypersensitivity","status":"COMPLETED","sponsor":"Unilever R&D","startDate":"2017-06-19","conditions":"Dentin Sensitivity","enrollment":272},{"nctId":"NCT03809910","phase":"PHASE2","title":"Dental Plaque Removal Ability of Prototype Power Toothbrush Versus a Manual Toothbrush in Healthy Participants","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2019-07-08","conditions":"Dental Plaque","enrollment":40},{"nctId":"NCT04155658","phase":"NA","title":"Evaluation of Efficacy of Sodium Monofluorophosphate (SMPF) Toothpastes on Enamel Lesion Remineralisation","status":"COMPLETED","sponsor":"Unilever R&D","startDate":"2019-11-25","conditions":"Enamel Caries","enrollment":55},{"nctId":"NCT04123665","phase":"PHASE3","title":"A Phase 3 Clinical Study Investigating the Gingivitis Efficacy of a Test Dentifrice Containing Stannous Fluoride","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2013-05-28","conditions":"Gingivitis","enrollment":98},{"nctId":"NCT04215432","phase":"NA","title":"Propolis Extract, Nanovitamin C and Nanovitamin E in Peri-implant Mucositis","status":"COMPLETED","sponsor":"Universidad Complutense de Madrid","startDate":"2018-05-01","conditions":"Peri-implant Mucositis","enrollment":46},{"nctId":"NCT03936556","phase":"PHASE4","title":"A Clinical Study to Assess the Effects of a Stannous Fluoride Dentifrice on Plaque and Gingivitis","status":"COMPLETED","sponsor":"Procter and Gamble","startDate":"2018-02-25","conditions":"Gingivitis","enrollment":84},{"nctId":"NCT04156152","phase":"NA","title":"Effectiveness of the Use of Desensitizing Dentifrices Based on Nanocrystals of Hydroxyapatite / 5% Potassium Nitrate / 1450ppm Sodium Monofluorophosphate and Potassium Nitrate 5% / 1426ppm Sodium Floride in the Treatment of Dentine Hypersensitivity. Test Randomized Clinical","status":"UNKNOWN","sponsor":"Universidad del Desarrollo","startDate":"2020-04-10","conditions":"Hypersensitivity Dentin","enrollment":32},{"nctId":"NCT04006470","phase":"","title":"Meta-analysis of Stannous Fluoride and the Effects on Enamel Erosion","status":"COMPLETED","sponsor":"Procter and Gamble","startDate":"2018-01-08","conditions":"Enamel Erosion","enrollment":172},{"nctId":"NCT04005417","phase":"","title":"Meta-analysis of Stannous Fluoride Dentifrice and the Effects on Dentine Hypersensitivity","status":"COMPLETED","sponsor":"Procter and Gamble","startDate":"2018-01-08","conditions":"Dentine Hypersensitivity","enrollment":1036},{"nctId":"NCT03970759","phase":"","title":"Meta-analysis of Stannous Fluoride and the Effects on Gingival Health","status":"COMPLETED","sponsor":"Procter and Gamble","startDate":"2018-01-08","conditions":"Gingivitis","enrollment":2890},{"nctId":"NCT02937636","phase":"NA","title":"To Investigate the Gingivitis Efficacy of a Stannous Fluoride Dentifrice in a Chinese Population","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2017-09-19","conditions":"Gingivitis","enrollment":128},{"nctId":"NCT03160703","phase":"NA","title":"Study to Investigate the Stain Control of Two Stannous Fluoride Dentifrices","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2017-07-10","conditions":"Extrinsic Dental Stain, Oral Hygiene","enrollment":220},{"nctId":"NCT02080273","phase":"PHASE4","title":"Six Month Plaque and Gingivitis Study Using Colgate Total Toothpaste","status":"COMPLETED","sponsor":"Colgate Palmolive","startDate":"2013-03","conditions":"Dental Plaque, Gingivitis","enrollment":135},{"nctId":"NCT03852056","phase":"PHASE3","title":"The Clinical Investigation of a New Toothpaste Containing Stannous Fluoride as Compared to a Commercially Available Fluoride Toothpaste in Reducing Plaque and Gingivitis","status":"COMPLETED","sponsor":"Colgate Palmolive","startDate":"2017-05-25","conditions":"Dental Plaque, Gingivitis","enrollment":98},{"nctId":"NCT02923895","phase":"PHASE4","title":"To Investigate the Efficacy of an Occluding Dentifrice in Dentinal Hypersensitivity (DH)","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2016-10-11","conditions":"Dentin Sensitivity","enrollment":197},{"nctId":"NCT02226562","phase":"PHASE2","title":"Clinical Study Investigating the Efficacy of a Mouthwash in Providing Long Term Relief From Dentinal Hypersensitivity","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2014-09-02","conditions":"Dentin Sensitivity","enrollment":191},{"nctId":"NCT02753075","phase":"NA","title":"A Study in Dentinal Hypersensitivity (DH) Participants to Assess the Efficacy of an Occluding Dentifrice.","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2015-09-08","conditions":"Dentin Sensitivity","enrollment":240},{"nctId":"NCT02924350","phase":"NA","title":"The Efficacy of an Occluding Dentifrice in Providing Relief From Dentinal Hypersensitivity (DH)","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2016-11-07","conditions":"Dentin Sensitivity","enrollment":205},{"nctId":"NCT02861664","phase":"NA","title":"Assessment of the Efficacy of an Experimental Occlusion Technology Dentifrice in Dentinal Hypersensitivity","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2016-09-21","conditions":"Dentin Sensitivity","enrollment":135},{"nctId":"NCT03598881","phase":"NA","title":"A Study to Assess the Impact of a Non-SLS Toothpaste Upon Oral Mucosal Desquamation","status":"COMPLETED","sponsor":"Unilever R&D","startDate":"2016-09-19","conditions":"Sloughing Skin, Mucosal Inflammation","enrollment":30},{"nctId":"NCT02768194","phase":"NA","title":"Dentine Tubule Occlusion Assessment in a Modified in Situ Model","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2016-07-06","conditions":"Dentin Sensitivity","enrollment":26},{"nctId":"NCT02789618","phase":"NA","title":"A Pilot Study to Substantiate the Use of the Jay Sensitivity Sensor Probe","status":"COMPLETED","sponsor":"Unilever R&D","startDate":"2016-10","conditions":"Dentine Sensitivity","enrollment":137},{"nctId":"NCT02676440","phase":"NA","title":"Effect of a Toothpaste and Serum Compared to Standard Fluoride Toothpaste on Gingival Health Over a Six Month Period.","status":"COMPLETED","sponsor":"Unilever R&D","startDate":"2015-07-03","conditions":"Healthy","enrollment":222},{"nctId":"NCT02371616","phase":"NA","title":"Clinical Study to Evaluate the Efficacy of Two Dentifrices for Dentine Hypersensitivity","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2014-09-29","conditions":"Dentine Sensitivity","enrollment":304},{"nctId":"NCT03072719","phase":"PHASE3","title":"The Efficacy of a Dentifrice in Providing Relief From Immediate and Short Term Relief From Dentinal Hypersensitivity","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2012-03-01","conditions":"Dentine Hypersensitivity","enrollment":120},{"nctId":"NCT02940821","phase":"NA","title":"Assessing the Effects of Three Oral Care Regimens","status":"COMPLETED","sponsor":"Pearl Network","startDate":"2016-05-30","conditions":"Dental Plaque, Gingivitis","enrollment":142},{"nctId":"NCT02750943","phase":"NA","title":"Potential of Stannous Fluoride Toothpaste to Reduce Gum Disease","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2015-11-01","conditions":"Gingivitis","enrollment":253},{"nctId":"NCT02773758","phase":"PHASE4","title":"Study to Investigate the Efficacy of an Occluding Dentifrice in Providing Relief From Dentine Hypersensitivity","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2016-01-01","conditions":"Dentin Sensitivity","enrollment":143},{"nctId":"NCT03287011","phase":"NA","title":"Efficacy of a Plaque Disclosing Toothpaste on Home Oral Hygiene Procedures","status":"UNKNOWN","sponsor":"Segi University","startDate":"2017-09-11","conditions":"Chronic Gingivitis, Plaque Induced","enrollment":50},{"nctId":"NCT03196648","phase":"NA","title":"Randomized Trial of a Gum Health Formulation","status":"COMPLETED","sponsor":"Glo Science, Inc.","startDate":"2015-05-01","conditions":"Periodontal Diseases, Gingivitis, Periodontitis","enrollment":39},{"nctId":"NCT02740803","phase":"NA","title":"Total Salivary Fluoride Concentration of Healthy Adult Subjects Following Toothbrushing With Different Formulations of Fluoridated Toothpastes With and Without Post-brushing Water Rinsing.","status":"COMPLETED","sponsor":"University of Leeds","startDate":"2016-04","conditions":"Caries","enrollment":120},{"nctId":"NCT02832375","phase":"PHASE3","title":"Investigating the Efficacy of an Occluding Dentifrice in Providing Relief From Dentinal Hypersensitivity","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2016-03-01","conditions":"Dentin Sensitivity","enrollment":242},{"nctId":"NCT02612064","phase":"NA","title":"The Efficacy of an Occluding Dentifrice in Providing Relief From Dentinal Hypersensitivity","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2015-11-01","conditions":"Dentin Sensitivity","enrollment":488},{"nctId":"NCT02751450","phase":"NA","title":"The Efficacy of an Occluding Dentifrice in Providing Relief From Dentinal Hypersensitivity(DH)","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2016-02-01","conditions":"Dentin Sensitivity","enrollment":263},{"nctId":"NCT02731833","phase":"PHASE4","title":"Short Term Clinical Study Investigating the Efficacy of an Occluding Dentifrice in Providing Relief From Dentinal Hypersensitivity","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2016-04-01","conditions":"Dentin Sensitivity","enrollment":229},{"nctId":"NCT02705716","phase":"NA","title":"Study Investigating Efficacy of an Occluding Dentifrice for Dentine Hypersensitivity","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2016-03-01","conditions":"Dentin Sensitivity","enrollment":409},{"nctId":"NCT02542943","phase":"NA","title":"Efficacy of Two Experimental Oral Rinses in Providing Long Term Relief From Dentinal Hypersensitivity","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2015-09","conditions":"Dentin Sensitivity","enrollment":240},{"nctId":"NCT03019224","phase":"PHASE4","title":"Effects of Desensitizing Dentifrices on the Reduction of Pain Sensitivity Caused by In-office Dental Whitening","status":"COMPLETED","sponsor":"University of Campinas, Brazil","startDate":"2016-01","conditions":"Tooth Whitening, Sensitivity","enrollment":4},{"nctId":"NCT02829879","phase":"PHASE3","title":"Effectiveness of Arginin and Potassium Nitrate Dentifrices in Dentin Hypersensitivity Therapy","status":"UNKNOWN","sponsor":"University of Chile","startDate":"2015-12","conditions":"Dentin Sensitivity","enrollment":50},{"nctId":"NCT02552589","phase":"NA","title":"Effect of Toothpaste on the Reduction of Plaque and Inflammation","status":"COMPLETED","sponsor":"Technische Universität Dresden","startDate":"2015-09","conditions":"Gingivitis, Dental Plaque","enrollment":241},{"nctId":"NCT00762528","phase":"PHASE4","title":"Compare Anti-inflammatory Dentifrices","status":"COMPLETED","sponsor":"Colgate Palmolive","startDate":"2009-02","conditions":"Gingivitis","enrollment":49},{"nctId":"NCT00941668","phase":"PHASE4","title":"Evaluate Inflammation Caused by Gingivitis in Adults","status":"COMPLETED","sponsor":"Colgate Palmolive","startDate":"2007-01","conditions":"Gingivitis","enrollment":49},{"nctId":"NCT01831817","phase":"PHASE2","title":"Exploratory Study to Evaluate the Efficacy of an Occlusion Based Dentifrice in Relief of Dentinal Hypersensitivity","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2013-01","conditions":"Dentinal Hypersensitivity","enrollment":140},{"nctId":"NCT01827670","phase":"PHASE3","title":"Investigating the Efficacy of a Dentifrice in Providing Long Term Relief From Dentinal Hypersensitivity","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2013-02","conditions":"Dentine Hypersensitivity","enrollment":119},{"nctId":"NCT01128946","phase":"PHASE4","title":"Enamel Remineralization Potential of Dentifrices in Situ","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2009-11","conditions":"Dental Caries","enrollment":83},{"nctId":"NCT00708305","phase":"PHASE3","title":"Evaluation of Plaque Fluid Fluoride Retention From Fluoride Toothpastes","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2008-06","conditions":"Dental Caries","enrollment":65},{"nctId":"NCT01657877","phase":"PHASE2","title":"Anti-caries Potential of a Sodium Monofluorophosphate and Calcium Sodium Phosphosilicate Dentifrice","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2012-05","conditions":"Caries","enrollment":100},{"nctId":"NCT01592851","phase":"PHASE3","title":"Clinical Efficacy of a Toothpaste in Providing Relief From the Pain of Dentinal Hypersensitivity","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2012-04","conditions":"Dentine Hypersensitivity","enrollment":113},{"nctId":"NCT01691560","phase":"PHASE2","title":"Exploratory Study to Evaluate an Occlusion Based Dentifrice in Relief of Dentinal Hypersensitivity","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2012-08","conditions":"Dentine Hypersensitivity","enrollment":140},{"nctId":"NCT01592864","phase":"PHASE3","title":"The Efficacy of a Dentifrice in Providing Relief From the Pain of Dentinal Hypersensitivity","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2012-03","conditions":"Dentine Hypersensitivity","enrollment":120},{"nctId":"NCT00758394","phase":"PHASE3","title":"Clinical Study to Compare Dental Plaque Control","status":"COMPLETED","sponsor":"Colgate Palmolive","startDate":"2007-09","conditions":"Dental Plaque","enrollment":29},{"nctId":"NCT01005966","phase":"PHASE3","title":"In Situ Caries Model of Fluoride Toothpastes","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2008-11","conditions":"Caries","enrollment":65},{"nctId":"NCT01494649","phase":"NA","title":"Pilot Study to Investigate the Efficacy of a Toothpaste in Providing Relief From Dentinal Hypersensitivity","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2011-09","conditions":"Dentinal Sensitivity, Hypersensitivity","enrollment":118},{"nctId":"NCT01589458","phase":"PHASE1","title":"Fluoride Availability in Saliva After Use of Sodium Fluoride or Monofluorophosphate Toothpastes","status":"COMPLETED","sponsor":"University of Campinas, Brazil","startDate":"2011-08","conditions":"Dental Caries","enrollment":12},{"nctId":"NCT00759031","phase":"PHASE3","title":"Investigation of Dental Plaque and Gingival Index","status":"COMPLETED","sponsor":"Colgate Palmolive","startDate":"2008-02","conditions":"Dental Plaque","enrollment":19}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":30,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Sodium monofluorophosphate dentifrice","genericName":"Sodium monofluorophosphate dentifrice","companyName":"Procter and Gamble","companyId":"procter-and-gamble","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Sodium monofluorophosphate releases fluoride ions in the oral cavity to strengthen tooth enamel and inhibit bacterial acid production, preventing dental caries. Used for Dental caries prevention, Tooth enamel strengthening.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}