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Sodium Fluoride Dentifrice
Sodium fluoride strengthens tooth enamel by promoting remineralization and inhibiting bacterial acid production to prevent dental caries.
Sodium fluoride strengthens tooth enamel by promoting remineralization and inhibiting bacterial acid production to prevent dental caries. Used for Prevention of dental caries (cavities), Fluorosis prevention in children with optimal fluoride exposure.
At a glance
| Generic name | Sodium Fluoride Dentifrice |
|---|---|
| Also known as | Regular Cavity Protection toothpaste |
| Sponsor | Procter and Gamble |
| Drug class | Fluoride topical agent |
| Target | Tooth enamel hydroxyapatite; bacterial enolase |
| Modality | Small molecule |
| Therapeutic area | Dental/Oral Health |
| Phase | FDA-approved |
Mechanism of action
Fluoride ions are incorporated into the hydroxyapatite crystal structure of tooth enamel, making it more resistant to demineralization by acids produced by cariogenic bacteria. Fluoride also inhibits enolase, a key glycolytic enzyme in oral bacteria, reducing their ability to metabolize sugars and produce cavity-causing acids. This dual mechanism reduces cavity incidence and promotes remineralization of early enamel lesions.
Approved indications
- Prevention of dental caries (cavities)
- Fluorosis prevention in children with optimal fluoride exposure
Common side effects
- Dental fluorosis (mild, cosmetic white spots or streaking)
- Nausea or gastrointestinal upset (if swallowed in large amounts)
- Allergic reactions (rare)
Key clinical trials
- Clinical Study to Assess the Efficacy of New Toothpaste Containing SnF as Compared to Colgate Cavity Protection Toothpaste on the Reduction of Enamel Erosion (PHASE3)
- Investigation of Colgate Dual Zinc Toothpaste as Compared to Colgate Cavity Protection Toothpaste in Controlling Plaque and Gingivitis (PHASE3)
- Hypersensitivity Reduction Efficacy: 5% Potassium Nitrate Toothpaste Compared to Colgate Cavity Protection Toothpaste (PHASE3)
- Clinical Research Study to Assess the Efficacy of Two Brushing Regimens in the Reduction of Established Dental Plaque and Gingivitis. (PHASE3)
- The Clinical of Stannous Fluoride Toothpaste and a Newly Designed Toothbrush Compared to Colgate Cavity Protection Toothpaste and a Regular Toothbrush in Reducing Plaque and Gingivitis. (PHASE3)
- Dentinal Hypersensitivity Reduction Efficacy Study (PHASE3)
- Efficacy of Manual Toothbrushes in Removing Tooth Stains (PHASE3)
- Dentinal Hypersensitivity Reduction (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Sodium Fluoride Dentifrice CI brief — competitive landscape report
- Sodium Fluoride Dentifrice updates RSS · CI watch RSS
- Procter and Gamble portfolio CI