{"id":"sodium-fluoride-dentifrice","safety":{"commonSideEffects":[{"rate":null,"effect":"Dental fluorosis (mild, cosmetic white spots or streaking)"},{"rate":null,"effect":"Nausea or gastrointestinal upset (if swallowed in large amounts)"},{"rate":null,"effect":"Allergic reactions (rare)"}]},"_chembl":null,"_dailymed":{"setId":"3f47f399-1a14-5264-e063-6394a90aeb1c","title":"SEAVUE DENTAL DESENSITIZER (POTASSIUM NITRATE AND SODIUM FLUORIDE DENTIFRICE) GEL, DENTIFRICE [XILING (ZHENJIANG) MEDICAL TECHNOLOGY CO., LTD.]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Fluoride ions are incorporated into the hydroxyapatite crystal structure of tooth enamel, making it more resistant to demineralization by acids produced by cariogenic bacteria. Fluoride also inhibits enolase, a key glycolytic enzyme in oral bacteria, reducing their ability to metabolize sugars and produce cavity-causing acids. This dual mechanism reduces cavity incidence and promotes remineralization of early enamel lesions.","oneSentence":"Sodium fluoride strengthens tooth enamel by promoting remineralization and inhibiting bacterial acid production to prevent dental caries.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:08:33.847Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention of dental caries (cavities)"},{"name":"Fluorosis prevention in children with optimal fluoride exposure"}]},"trialDetails":[{"nctId":"NCT07442136","phase":"PHASE3","title":"Clinical Study to Assess the Efficacy of New Toothpaste Containing SnF as Compared to Colgate Cavity Protection Toothpaste on the Reduction of Enamel Erosion","status":"ACTIVE_NOT_RECRUITING","sponsor":"Colgate Palmolive","startDate":"2026-03-03","conditions":"Enamel Erosion","enrollment":80},{"nctId":"NCT06430060","phase":"PHASE3","title":"Investigation of Colgate Dual Zinc Toothpaste as Compared to Colgate Cavity Protection Toothpaste in Controlling Plaque and Gingivitis","status":"COMPLETED","sponsor":"Colgate Palmolive","startDate":"2024-04-15","conditions":"Plaque, Dental, Gingivitis","enrollment":86},{"nctId":"NCT06956599","phase":"PHASE3","title":"Hypersensitivity Reduction Efficacy: 5% Potassium Nitrate Toothpaste Compared to Colgate Cavity Protection Toothpaste","status":"COMPLETED","sponsor":"Colgate Palmolive","startDate":"2025-05-10","conditions":"Dentin Hypersensitivity","enrollment":80},{"nctId":"NCT06244303","phase":"PHASE3","title":"Clinical Research Study to Assess the Efficacy of Two Brushing Regimens in the Reduction of Established Dental Plaque and Gingivitis.","status":"COMPLETED","sponsor":"Colgate Palmolive","startDate":"2024-01-22","conditions":"Gingivitis, Plaque","enrollment":82},{"nctId":"NCT06427499","phase":"PHASE3","title":"The Clinical of Stannous Fluoride Toothpaste and a Newly Designed Toothbrush Compared to Colgate Cavity Protection Toothpaste and a Regular Toothbrush in Reducing Plaque and Gingivitis.","status":"COMPLETED","sponsor":"Colgate Palmolive","startDate":"2024-04-22","conditions":"Plaque, Gingivitis","enrollment":95},{"nctId":"NCT06960148","phase":"PHASE3","title":"Dentinal Hypersensitivity Reduction Efficacy Study","status":"COMPLETED","sponsor":"Colgate Palmolive","startDate":"2025-03-04","conditions":"Sensitivity, Tooth","enrollment":95},{"nctId":"NCT06486974","phase":"PHASE3","title":"Efficacy of Manual Toothbrushes in Removing Tooth Stains","status":"COMPLETED","sponsor":"Colgate Palmolive","startDate":"2024-09-23","conditions":"Tooth Discoloration","enrollment":80},{"nctId":"NCT06244290","phase":"PHASE3","title":"Dentinal Hypersensitivity Reduction","status":"COMPLETED","sponsor":"Colgate Palmolive","startDate":"2020-09-28","conditions":"Dentinal Hypersensitivity","enrollment":123},{"nctId":"NCT07471477","phase":"PHASE3","title":"Bacterial Reduction for a Manual Toothbrush With a 360-Degree Mouth Cleaner Design Versus a Standard Toothbrush","status":"RECRUITING","sponsor":"Colgate Palmolive","startDate":"2026-03-01","conditions":"Bacterial Load Reduction","enrollment":60},{"nctId":"NCT07210138","phase":"PHASE3","title":"Clinical Investigation of PerioGard (Test) Regimen","status":"COMPLETED","sponsor":"Colgate Palmolive","startDate":"2025-08-18","conditions":"Gingivitis","enrollment":80},{"nctId":"NCT06660069","phase":"NA","title":"A Study to Evaluate the Efficacy of a Stannous Fluoride Toothpaste With a Cetylpyridinium Chloride Mouthwash in Improving Gingival Health and Reducing Plaque Accumulation","status":"COMPLETED","sponsor":"HALEON","startDate":"2024-11-18","conditions":"Dental Plaque, Gingivitis","enrollment":199},{"nctId":"NCT05601154","phase":"EARLY_PHASE1","title":"Fluoride in Saliva After Use of Fluoride Toothpastes Followed by Fluoride Mouthrinses","status":"COMPLETED","sponsor":"University of Michigan","startDate":"2023-03-23","conditions":"Dental Caries","enrollment":20},{"nctId":"NCT07273539","phase":"NA","title":"A Study to Evaluate the Effect of a Test (Sodium Bicarbonate) Toothpaste on the Oral Microbiome","status":"COMPLETED","sponsor":"HALEON","startDate":"2025-10-27","conditions":"Gingivitis","enrollment":74},{"nctId":"NCT07458464","phase":"PHASE3","title":"A Study to Investigate Stannous Fluoride Containing Toothpaste on Antibacterial Effects in the Different Regions of the Mouth","status":"NOT_YET_RECRUITING","sponsor":"Colgate Palmolive","startDate":"2026-05","conditions":"Plaque, Gingivitis","enrollment":100},{"nctId":"NCT07428603","phase":"NA","title":"Extrinsic Tooth Whitening Evaluation of a Whitening Toothpaste","status":"COMPLETED","sponsor":"Church & Dwight Company, Inc.","startDate":"2024-08-08","conditions":"Stain Removal Efficacy","enrollment":118},{"nctId":"NCT07425509","phase":"NA","title":"Evaluation of a Stannous Fluoride Dentifrice for Control of Oral Malodor","status":"COMPLETED","sponsor":"Church & Dwight Company, Inc.","startDate":"2024-09-09","conditions":"Oral Malodor (Halitosis)","enrollment":49},{"nctId":"NCT07419737","phase":"NA","title":"Dental Plaque Prevention Efficacy of a Stannous Fluoride Toothpaste","status":"COMPLETED","sponsor":"Church & Dwight Company, Inc.","startDate":"2024-10-16","conditions":"Dental Plaque","enrollment":91},{"nctId":"NCT07419763","phase":"NA","title":"Intra Oral Appliance (IOA) Model Evaluating the Efficacy of Sensitive Toothpaste","status":"COMPLETED","sponsor":"Church & Dwight Company, Inc.","startDate":"2025-04-15","conditions":"Dental Caries","enrollment":30},{"nctId":"NCT04954313","phase":"PHASE4","title":"Baseline Oral Health Study: UnCoVer the Connections to General Health","status":"COMPLETED","sponsor":"University of North Carolina, Chapel Hill","startDate":"2021-09-28","conditions":"Cardiovascular Diseases, Diabetes Type 2","enrollment":786},{"nctId":"NCT07398846","phase":"PHASE3","title":"Efficacy of a Stannous Fluoride Toothpaste, Cetylpyridinium Chloride Mouthwash, and Battery Toothbrush Regimen in Reducing Established Dental Plaque and Gingivitis.","status":"RECRUITING","sponsor":"Colgate Palmolive","startDate":"2026-01-26","conditions":"Plaque","enrollment":135},{"nctId":"NCT07398378","phase":"PHASE3","title":"Clinical Investigation of Oral Malodor for Max Fresh Toothpaste Containing Zinc Citrate Versus a Commercially Available Regular Fluoride Toothpaste","status":"NOT_YET_RECRUITING","sponsor":"Colgate Palmolive","startDate":"2026-01-28","conditions":"Oral Malodor","enrollment":80},{"nctId":"NCT07224828","phase":"PHASE3","title":"The Efficacy of a Battery Toothbrush in the Reduction of Established Plaque and Gingivitis","status":"COMPLETED","sponsor":"Colgate Palmolive","startDate":"2025-10-14","conditions":"Plaque, Gingivitis","enrollment":130},{"nctId":"NCT07352956","phase":"NA","title":"A Clinical Study to Evaluate the Effectiveness of an Test Toothpaste for the Relief of Dentin Hypersensitivity in a Chinese Population","status":"RECRUITING","sponsor":"HALEON","startDate":"2026-01-16","conditions":"Dentin Sensitivity","enrollment":100},{"nctId":"NCT07124533","phase":"PHASE3","title":"Effectiveness of Toothpaste Tablets on Plaque, Gingival Health and Caries Experiences","status":"NOT_YET_RECRUITING","sponsor":"Loma Linda University","startDate":"2026-05","conditions":"Gingival Inflammation, Dental Caries","enrollment":50},{"nctId":"NCT06602466","phase":"NA","title":"A Clinical Study Investigating the Effect of an Experimental Toothpaste Containing Stannous Fluoride in Improving Gingival Health","status":"COMPLETED","sponsor":"HALEON","startDate":"2024-09-23","conditions":"Dental Plaque, Gingivitis","enrollment":175},{"nctId":"NCT07169188","phase":"NA","title":"A Clinical Study Investigating the Efficacy of an Experimental Toothpaste Containing Stannous Fluoride in Improving Gingival Health","status":"COMPLETED","sponsor":"HALEON","startDate":"2025-09-09","conditions":"Dental Plaque, Gingivitis","enrollment":154},{"nctId":"NCT07225478","phase":"PHASE3","title":"Clinical Study to Evaluate the Tooth Whitening Efficacy of a New NextGen In-office Whitening System","status":"COMPLETED","sponsor":"Colgate Palmolive","startDate":"2025-10-31","conditions":"Health Adult Subjects","enrollment":180},{"nctId":"NCT07307716","phase":"NA","title":"Clear Aligner Cleaning: Brushing, Chlorhexidine, and BlueM Effects on Oral Microbial Ecology and Periodontal Indices","status":"NOT_YET_RECRUITING","sponsor":"Riyadh Elm University","startDate":"2026-02","conditions":"Gingivitis, Dental Plaque","enrollment":21},{"nctId":"NCT07317128","phase":"NA","title":"Study to Evaluate the Effectiveness of Test Dentifrice in the Relief of Dentinal Hypersensitivity","status":"COMPLETED","sponsor":"HALEON","startDate":"2013-01-20","conditions":"Dentin Sensitivity","enrollment":120},{"nctId":"NCT05470023","phase":"NA","title":"Imaging-based Assessment of Oral Biofilm and Gingival Health","status":"RECRUITING","sponsor":"University of California, Irvine","startDate":"2022-09-01","conditions":"Plaque, Dental, Gingivitis","enrollment":275},{"nctId":"NCT07274189","phase":"NA","title":"Periodontal Health and Sodium Bicarbonate Toothpaste","status":"RECRUITING","sponsor":"University of Plymouth","startDate":"2024-12-04","conditions":"Periodontal Diseases","enrollment":100},{"nctId":"NCT07255040","phase":"NA","title":"A Clinical Study to Evaluate the Effectiveness of an Experimental Toothpaste in Improving Gum Health and Reducing Plaque Accumulation","status":"RECRUITING","sponsor":"HALEON","startDate":"2025-11-19","conditions":"Dental Plaque, Gingivitis","enrollment":300},{"nctId":"NCT06608368","phase":"PHASE4","title":"A Clinical Study Assessing the Effects of a Marketed Dentifrice on Tooth Sensitivity While Undergoing Tooth Bleaching","status":"COMPLETED","sponsor":"HALEON","startDate":"2024-10-07","conditions":"Dentin Sensitivity","enrollment":90},{"nctId":"NCT07223060","phase":"PHASE2, PHASE3","title":"Efficacy of Toothpaste Containing 0.454% Stannous Fluoride as Compared to a Regular Fluoride Toothpaste Containing 0.76% Sodium Monofluorophosphate in Controlling Supragingival Calculus Formation Over a 12-week Period.","status":"COMPLETED","sponsor":"Colgate Palmolive","startDate":"2017-05-17","conditions":"Calculus, Dental","enrollment":100},{"nctId":"NCT07276672","phase":"PHASE3","title":"Efficacy of a Toothpaste Containing Hydrogen Peroxide as Compared to a Regular Fluoride Toothpaste Without Hydrogen Peroxide in the Immediate Removal of Tooth Stains After a Single Brushing.","status":"COMPLETED","sponsor":"Colgate Palmolive","startDate":"2025-11-20","conditions":"Whitening","enrollment":80},{"nctId":"NCT07275684","phase":"NA","title":"Charcoal Toothbrushes and Bacterial Contamination: a Clinical Trial.","status":"COMPLETED","sponsor":"Mohammed V University in Rabat","startDate":"2025-04-16","conditions":"Oral Hygiene, Toothbrush Contamination, Bacterial Contamination","enrollment":32},{"nctId":"NCT07257042","phase":"PHASE3","title":"Oothpaste Containing 8% Arginine Compared to Colgate Cavity Protection Toothpaste in Reducing Dentinal Hypersensitivity","status":"COMPLETED","sponsor":"Colgate Palmolive","startDate":"2025-07-14","conditions":"Hypersensitivity","enrollment":80},{"nctId":"NCT05335239","phase":"NA","title":"Domiciliary Professional Oral Care for Dependent Older Adults","status":"COMPLETED","sponsor":"Karolinska Institutet","startDate":"2021-12-06","conditions":"Dental Caries of Root Surface, Aging","enrollment":194},{"nctId":"NCT06411522","phase":"NA","title":"Clinical and Microbiological Comparison of 0.12% CHX and 0.05% CHX+0.05%CPC Mouthwashes in TPS Patients","status":"COMPLETED","sponsor":"University of Siena","startDate":"2024-05-20","conditions":"Chlorhexidine, Gingivitis, Periodontitis","enrollment":72},{"nctId":"NCT07241052","phase":"NA","title":"Oral-Spray Bacillus Spore Probiotic in Preventing and Supporting Treatment of Dental Caries in Children","status":"NOT_YET_RECRUITING","sponsor":"Anabio R&D","startDate":"2025-12-01","conditions":"Dental Caries","enrollment":130},{"nctId":"NCT07229105","phase":"NA","title":"Comparative Effectiveness of Remineralization Agents on Attachment-Associated Demineralization in Clear Aligner Patients","status":"COMPLETED","sponsor":"Bezmialem Vakif University","startDate":"2024-08-12","conditions":"White Spot Lesions, Demineralization, Dental Caries","enrollment":40},{"nctId":"NCT07149376","phase":"PHASE3","title":"To Assess the Efficacy of a Toothpaste Containing 8% Arginine as Compared to Colgate Cavity Protection Toothpaste in the Reduction of Dentinal Hypersensitivity.","status":"COMPLETED","sponsor":"Colgate Palmolive","startDate":"2025-08-18","conditions":"Sensitivity, Tooth","enrollment":84},{"nctId":"NCT07223073","phase":"PHASE3","title":"A Clinical Study Conducted in the Bangkok, Thailand Area, to Investigate the Clinical Efficacy of a New Toothpaste","status":"COMPLETED","sponsor":"Colgate Palmolive","startDate":"2017-12-21","conditions":"Oral Malodor","enrollment":80},{"nctId":"NCT07029438","phase":"PHASE4","title":"Comparative Efficacy of Floss and Essential Oil/CPC+Zn Mouthwashes in Reducing Dental Plaque and Gingivitis","status":"COMPLETED","sponsor":"Colgate Palmolive","startDate":"2025-07-07","conditions":"Dental Plaque, Gingivitis","enrollment":228},{"nctId":"NCT05482256","phase":"NA","title":"A Study of Detergents in the Pathogenesis of Eosinophilic Esophagitis","status":"COMPLETED","sponsor":"Mayo Clinic","startDate":"2022-09-12","conditions":"Eosinophilic Esophagitis","enrollment":12},{"nctId":"NCT07211061","phase":"PHASE4","title":"A Study is to Evaluate a Regimen on Gingivitis Using Traditional and Novel Assessment Methods","status":"COMPLETED","sponsor":"Procter and Gamble","startDate":"2011-09-21","conditions":"Gingivitis","enrollment":69},{"nctId":"NCT06949072","phase":"NA","title":"A Clinical Study to Assess an Experimental Dentifrice in an Experimental Model of Early Stage Caries","status":"COMPLETED","sponsor":"HALEON","startDate":"2025-04-28","conditions":"Dental Caries","enrollment":47},{"nctId":"NCT05765058","phase":"NA","title":"The Efficacy of Tooth Mouse, SFD and NaF in Caries Activity in Root Caries. A Randomized Clinical Trial","status":"NOT_YET_RECRUITING","sponsor":"University of Bern","startDate":"2026-02-01","conditions":"Root Caries, NaF, SDF","enrollment":136},{"nctId":"NCT07158112","phase":"PHASE4","title":"Assessing Gingivitis and Plaque From a Marketed Toothpaste","status":"ACTIVE_NOT_RECRUITING","sponsor":"Procter and Gamble","startDate":"2025-08-30","conditions":"Gingivitis","enrollment":120},{"nctId":"NCT06833970","phase":"","title":"Toothpastes With Different Contents and Tooth Color","status":"COMPLETED","sponsor":"Taner OZTURK, DDS, MS","startDate":"2024-05-01","conditions":"White Spot Lesion of Tooth, Tooth Color, Dentistry","enrollment":45},{"nctId":"NCT07177053","phase":"PHASE2","title":"Hydroxyapatite vs Fluoride Toothpaste for MIH Remineralization","status":"NOT_YET_RECRUITING","sponsor":"Dubai Health","startDate":"2025-11","conditions":"Molar Incisor Hypomineralisation","enrollment":160},{"nctId":"NCT06378008","phase":"NA","title":"A Clinical Study to Evaluate the Anti-Sensitivity Effect of a Calcium Sodium Phosphosilicate Toothpaste in a Population of Dentin Hypersensitivity Sufferers","status":"COMPLETED","sponsor":"HALEON","startDate":"2024-04-16","conditions":"Dentin Sensitivity","enrollment":217},{"nctId":"NCT07160166","phase":"NA","title":"Determination of the Oral Irritation Potential of Two Alcohol-Free Rinses","status":"COMPLETED","sponsor":"Kenvue Brands LLC","startDate":"2025-07-11","conditions":"Oral Health","enrollment":169},{"nctId":"NCT07068204","phase":"NA","title":"Comparative Study of Caries-Preventive Effects: 2% Calcium Hypophosphite Toothpaste vs. Sodium Fluoride Toothpaste (1450ppm F)","status":"NOT_YET_RECRUITING","sponsor":"Dr. Joachim Enax","startDate":"2025-09","conditions":"Caries, Dental, Calcium Hypophosphite, Fluoridation","enrollment":164},{"nctId":"NCT06957249","phase":"PHASE3","title":"Clinical Study to Evaluate the Tooth Whitening Efficacy","status":"COMPLETED","sponsor":"Colgate Palmolive","startDate":"2025-04-25","conditions":"Whitening","enrollment":80},{"nctId":"NCT05258721","phase":"PHASE2","title":"Efficacy of ClōSYS® Sensitive Fluoride Toothpaste and ClōSYS® Sensitive Rinse Regimen on MGI, PI and BOP","status":"COMPLETED","sponsor":"Rowpar Pharmaceuticals, Inc.","startDate":"2021-07-06","conditions":"Gingivitis, Periodontitis","enrollment":60},{"nctId":"NCT07120243","phase":"NA","title":"Clinical Effectiveness of Bioactive Silica Based With Calcium Toothpaste","status":"NOT_YET_RECRUITING","sponsor":"Rawda Hesham Abd ElAziz","startDate":"2025-08-15","conditions":"Caries; Initial, Caries Active","enrollment":20},{"nctId":"NCT06150573","phase":"NA","title":"A Study Assessing the Effects of an Experimental Dentifrice in Maintaining Tooth Color Following Tooth Bleaching","status":"COMPLETED","sponsor":"HALEON","startDate":"2023-11-27","conditions":"Dentin Sensitivity, Oral Hygiene","enrollment":160},{"nctId":"NCT07080645","phase":"NA","title":"BIOSILITACE AS A DESENSITIZING AGENTIN HMI","status":"NOT_YET_RECRUITING","sponsor":"University of Sao Paulo","startDate":"2025-07-30","conditions":"Sensitive Dentin, Hypomineralization Molar Incisor, Pain","enrollment":42},{"nctId":"NCT06792812","phase":"PHASE2","title":"The Impact of Ginger Mouthwash on the Pregnant Women With Stress and Gingivitis","status":"COMPLETED","sponsor":"Al-Mustansiriyah University","startDate":"2025-01-25","conditions":"Mouth Diseases, Bleeding Gum, Stress","enrollment":45},{"nctId":"NCT06048809","phase":"NA","title":"A Study to Evaluate the Effect of a Stannous Fluoride Toothpaste on the Oral Microbiome","status":"COMPLETED","sponsor":"HALEON","startDate":"2024-04-10","conditions":"Oral Health","enrollment":56},{"nctId":"NCT06892834","phase":"PHASE2","title":"Assessing Gingivitis of 3 Different Dentifrices Compared to a Negative Control.","status":"COMPLETED","sponsor":"Procter and Gamble","startDate":"2025-03-25","conditions":"Gingivitis","enrollment":120},{"nctId":"NCT06010732","phase":"PHASE3","title":"In Situ Comparison of the Remineralization Potential of Optimized Fluoride Dentifrice With Control Fluoride Dentifrice","status":"COMPLETED","sponsor":"Indiana University","startDate":"2023-10-02","conditions":"Caries","enrollment":52},{"nctId":"NCT06733285","phase":"NA","title":"Clinical Study to Investigate the Ability of a Stannous Fluoride Toothpaste to Protect From Dentine Hypersensitivity","status":"COMPLETED","sponsor":"HALEON","startDate":"2025-02-04","conditions":"Dentin Sensitivity","enrollment":85},{"nctId":"NCT06962956","phase":"PHASE1","title":"Evaluating Gingivitis and Systemic Biomarkers","status":"ACTIVE_NOT_RECRUITING","sponsor":"Procter and Gamble","startDate":"2025-04-30","conditions":"Gingivitis","enrollment":135},{"nctId":"NCT06847217","phase":"NA","title":"Effect of Applying Oral Hygiene Care on Swallowing in Stroke Patients With Oropharyngeal Dysphagia","status":"ENROLLING_BY_INVITATION","sponsor":"University Hospital, Ghent","startDate":"2025-05-21","conditions":"Dysphagia After Stroke","enrollment":260},{"nctId":"NCT06557980","phase":"NA","title":"Effectiveness of Calcium Silicate and Sodium Fluoride Nanoparticles in The Management of Dentin Hypersensitivity","status":"NOT_YET_RECRUITING","sponsor":"Minia University","startDate":"2025-05","conditions":"Dentin Hypersensitivity","enrollment":60},{"nctId":"NCT05803109","phase":"NA","title":"Efficacy of Coconut Oil With Peppermint Essential for Oral Hygiene Routine","status":"COMPLETED","sponsor":"Cairo University","startDate":"2024-08-21","conditions":"Fluoride Adverse Reaction","enrollment":40},{"nctId":"NCT06954779","phase":"PHASE3","title":"Arginine Plaque Metabolism Pilot Clinical Study","status":"COMPLETED","sponsor":"Colgate Palmolive","startDate":"2024-07-24","conditions":"Plaque, Dental","enrollment":20},{"nctId":"NCT05782348","phase":"NA","title":"Evaluating the Effectiveness of a Cognitive Behavioral Intervention (CBI)","status":"COMPLETED","sponsor":"Howard University","startDate":"2023-08-06","conditions":"Adolescent Behavior, Dental Plaque, Gingivitis","enrollment":150},{"nctId":"NCT05512156","phase":"NA","title":"Toothbrushing Program in Saudi Arabia \"TOPS\"","status":"COMPLETED","sponsor":"University of Glasgow","startDate":"2022-09-18","conditions":"Dental Caries in Children","enrollment":588},{"nctId":"NCT06937697","phase":"PHASE3","title":"Clinical of Hypersensitivity Reduction Efficacy on Two Toothpastes","status":"COMPLETED","sponsor":"Colgate Palmolive","startDate":"2024-10-08","conditions":"Hypersensitivity","enrollment":87},{"nctId":"NCT06932211","phase":"NA","title":"A Study to Measure the Effect of a Toothpaste Containing Proteins and Enzymes and a Fluoride Toothpaste on Gingival Health","status":"COMPLETED","sponsor":"Unilever R&D","startDate":"2018-10-29","conditions":"Gingival Inflammation, Dental Plaque","enrollment":251},{"nctId":"NCT06143670","phase":"NA","title":"A Clinical Study Investigating the Effects of a Dentifrice Containing 0.454% Stannous Fluoride on Gingivitis Treatment and Plaque Reduction When Used Twice Daily for 12 Weeks","status":"COMPLETED","sponsor":"HALEON","startDate":"2023-11-29","conditions":"Gingivitis","enrollment":159},{"nctId":"NCT06798441","phase":"NA","title":"Determination of the Oral Irritation Potential of a Fluoride Rinse in Children","status":"COMPLETED","sponsor":"Johnson & Johnson Consumer and Personal Products Worldwide","startDate":"2025-01-20","conditions":"Healthy","enrollment":161},{"nctId":"NCT06172764","phase":"PHASE4","title":"A Randomized Controlled Trial of Vitamin D Supplementation on Salivary Biomarkers and Cariogenic Oral Microbiome","status":"RECRUITING","sponsor":"Dow University of Health Sciences","startDate":"2023-12-12","conditions":"Dental Caries, White Spot Lesion, Initial Caries","enrollment":90},{"nctId":"NCT06854068","phase":"NA","title":"Evaluation of the Combined Effect of Bioactive Toothpastes, Desensitizing Agents and Er-YAG Laser on Dentin Hypersensitivity: an In-Vivo Study","status":"NOT_YET_RECRUITING","sponsor":"Ege University","startDate":"2025-05-01","conditions":"Dentin Hypersensitivity","enrollment":40},{"nctId":"NCT05805865","phase":"PHASE3","title":"Efficacy of Eco-Friendly Toothpaste Tablets Versus Conventional Toothpaste Using PI and GI Index","status":"COMPLETED","sponsor":"Loma Linda University","startDate":"2023-01-03","conditions":"Gingival Inflammation","enrollment":40},{"nctId":"NCT06821724","phase":"NA","title":"Effect of Different Remineralizing Agents on White Spot Lesions Treatment in Children","status":"COMPLETED","sponsor":"National Research Centre, Egypt","startDate":"2024-12-01","conditions":"White Spot Lesion of Tooth","enrollment":100},{"nctId":"NCT06800443","phase":"NA","title":"A Cosmetic Study to Measure the Change in Tooth Colour After Using Instant Whitening Prototypes Compared to a Negative Control","status":"COMPLETED","sponsor":"Unilever R&D","startDate":"2018-12-03","conditions":"Tooth Color","enrollment":68},{"nctId":"NCT05654662","phase":"NA","title":"A Clinical Study Investigating the Effects of a Dentifrice Containing 67% Sodium Bicarbonate When Used Twice Daily for 12 Weeks on Gingivitis Treatment and Plaque Removal","status":"COMPLETED","sponsor":"HALEON","startDate":"2023-02-20","conditions":"Gingivitis, Dental Plaque","enrollment":197},{"nctId":"NCT06749275","phase":"NA","title":"High Fluoride and Root Caries in Older Adults (NIT-RCL-UTALCA)","status":"COMPLETED","sponsor":"University of Talca","startDate":"2021-04-12","conditions":"Root Caries, Cognitive Impairment, Fluor","enrollment":179},{"nctId":"NCT05750745","phase":"NA","title":"A Clinical Study to Evaluate the Efficacy of a Stannous Fluoride Toothpaste for the Relief of Dentine Hypersensitivity in a Chinese Population","status":"COMPLETED","sponsor":"HALEON","startDate":"2023-05-08","conditions":"Dentin Sensitivity","enrollment":416},{"nctId":"NCT06659471","phase":"NA","title":"Brief Title: a Clinical Study to Assess Gingivitis","status":"COMPLETED","sponsor":"Procter and Gamble","startDate":"2022-03-07","conditions":"Gingival Diseases","enrollment":120},{"nctId":"NCT04373356","phase":"NA","title":"Non-invasive Caries Management: Clinical Study","status":"COMPLETED","sponsor":"Western University, Canada","startDate":"2022-10-01","conditions":"Caries,Dental, Caries Arrested","enrollment":30},{"nctId":"NCT04601103","phase":"NA","title":"3M Oral Rinse Incidence and Patient Acceptance of Sloughing When Used With Sodium Lauryl Sulfate (SLS) Toothpastes","status":"TERMINATED","sponsor":"Solventum US LLC","startDate":"2020-01-06","conditions":"Oral Mucosal Disorder","enrollment":53},{"nctId":"NCT02999230","phase":"NA","title":"Probiotics That Moderate pH and Antagonize Pathogens to Promote Oral Health","status":"COMPLETED","sponsor":"University of Florida","startDate":"2017-02-22","conditions":"Dental Caries","enrollment":170},{"nctId":"NCT02617407","phase":"PHASE1","title":"Livionex Oral Microbiome and Dental Plaque Control in HSCT Recipients","status":"COMPLETED","sponsor":"University of California, San Francisco","startDate":"2016-07-28","conditions":"Dental Plaque","enrollment":44},{"nctId":"NCT05524948","phase":"NA","title":"A Clinical Study to Examine the Effects of an Experimental Toothpaste Compared to a Regular Fluoride Toothpaste on Breath Odor in a Population With Gingivitis","status":"COMPLETED","sponsor":"HALEON","startDate":"2022-09-26","conditions":"Halitosis","enrollment":104},{"nctId":"NCT06563518","phase":"PHASE2","title":"Clinical Study of Toothpaste Containing Zinc Lactate as Compared to Colgate Cavity Protection Toothpaste.","status":"COMPLETED","sponsor":"Colgate Palmolive","startDate":"2022-01-18","conditions":"Gingivitis, Plaque","enrollment":92},{"nctId":"NCT06473792","phase":"NA","title":"Effect of Probiotic Toothpaste and Regular Toothpaste on Plaque Levels of Orthodontic Patients","status":"COMPLETED","sponsor":"Kanza Tahir","startDate":"2024-06-04","conditions":"Plaque","enrollment":52},{"nctId":"NCT04750902","phase":"PHASE2","title":"A Clinical Trial to Assess the Safety and the Anti-caries Efficacy of COL 101 (Arginine) Non-fluoride Dentifrices in Comparison With 0.24% Sodium Fluoride (1100 Ppm F) Dentifrice Control in 10 to 14-year-old Children","status":"COMPLETED","sponsor":"Colgate Palmolive","startDate":"2021-01-21","conditions":"Dental Caries","enrollment":2000},{"nctId":"NCT06128434","phase":"NA","title":"Effectiveness of Different Toothpastes in Treating White Spot Lesions","status":"UNKNOWN","sponsor":"Mansoura University","startDate":"2023-11-30","conditions":"White Spot Lesions [Initial Caries] on Smooth Surface of Tooth","enrollment":21},{"nctId":"NCT05206539","phase":"PHASE3","title":"Efficacy of Different Agents in Treatment of Initial Caries on Smooth Surfaces in Permanent Teeth in Children","status":"UNKNOWN","sponsor":"Plovdiv Medical University","startDate":"2024-06-01","conditions":"White Spot Lesion of Tooth","enrollment":40},{"nctId":"NCT06166745","phase":"NA","title":"Efficacy of Sensi-IP Toothpaste in the Treatment of Dentinal Hypersensitivity Compared to a Sodium Fluoride Toothpaste","status":"COMPLETED","sponsor":"IR Scientific Inc.","startDate":"2023-11-06","conditions":"Dentinal Hypersensitivity","enrollment":46},{"nctId":"NCT06353165","phase":"PHASE3","title":"Anti-bacterial Clinical Study on Teeth, Tongue, Cheek, Gum, and Saliva","status":"COMPLETED","sponsor":"Colgate Palmolive","startDate":"2023-03-08","conditions":"Plaque, Dental","enrollment":100},{"nctId":"NCT05459558","phase":"NA","title":"Clinical Study to Investigate the Tooth Stain Removal Efficacy of Two Experimental Toothpastes Compared to a Standard Toothpaste When Used Twice Daily for 8 Weeks","status":"COMPLETED","sponsor":"HALEON","startDate":"2022-09-15","conditions":"Oral Hygiene","enrollment":280},{"nctId":"NCT05485662","phase":"NA","title":"Remineralization of Molar Incisor Hypomineralization (MIH) With a Hydroxyapatite Toothpaste","status":"COMPLETED","sponsor":"The University of Texas Health Science Center at San Antonio","startDate":"2022-09-06","conditions":"Molar Incisor Hypomineralization","enrollment":15},{"nctId":"NCT05590897","phase":"PHASE1, PHASE2","title":"Assessment of Photodynamic Therapy With Annatto and Led for the Treatment of Halitosis in Mouth-Breathing Children","status":"COMPLETED","sponsor":"University of Nove de Julho","startDate":"2023-02-01","conditions":"Halitosis","enrollment":52},{"nctId":"NCT06300905","phase":"PHASE3","title":"Clinical Study on Malodor","status":"COMPLETED","sponsor":"Colgate Palmolive","startDate":"2023-06-01","conditions":"Oral Malodor","enrollment":100}],"_emaApprovals":[],"_faersSignals":[{"count":1,"reaction":"HYPOAESTHESIA"},{"count":1,"reaction":"HYPOAESTHESIA ORAL"},{"count":1,"reaction":"URTICARIA GENERALISED"}],"_approvalHistory":[],"publicationCount":102,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Regular Cavity Protection toothpaste"],"phase":"marketed","status":"active","brandName":"Sodium Fluoride Dentifrice","genericName":"Sodium Fluoride Dentifrice","companyName":"Procter and Gamble","companyId":"procter-and-gamble","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Sodium fluoride strengthens tooth enamel by promoting remineralization and inhibiting bacterial acid production to prevent dental caries. Used for Prevention of dental caries (cavities), Fluorosis prevention in children with optimal fluoride exposure.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}